Publications by authors named "Larisa G Kubarskaya"
Trace amine-associated receptors (TAARs) are a group of G protein-coupled receptors that are expressed in the olfactory epithelium, central nervous system, and periphery. TAAR family generally consists of nine types of receptors (TAAR1-9), which can detect biogenic amines. During the last 5 years, the TAAR5 receptor became one of the most intriguing receptors in this subfamily.
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- Interest in trace amines and their receptors in mammals has increased over the past two decades, particularly regarding trace amine-associated receptor 9 (TAAR9), which is not well understood.
- Researchers created two new TAAR9 knockout (TAAR9-KO) rat strains using CRISPR-Cas9 to study the receptor's role in physiology.
- While most blood parameters remained unchanged, the study found significant decreases in total and low-density lipoprotein cholesterol levels in TAAR9-KO rats, suggesting a potential link between TAAR9 and cholesterol regulation.