The use of tenoten and tenoten (pediatric formulation) as a drug for premedication in adults and children during outpatients dentist visit.

The use of tenoten and tenoten (pediatric formulation) for premedication in adults and children before dental treatment reduces patient anxiety; the effect is comparable with that of classical anxiolytics and is not accompanied by side effects. These preparations can be recommended for wide use in dentistry.

[Mexidol effects in extreme conditions (experiments with animals)].

In extreme conditions like a new situation, bright light, open space, immobilization, height (the open field and lifted cruciform labyrinth test) and a conflict between an unavoidable action and fear of painful mexidol at the doses of 50 and 100 mg/kg of a body weight eliminates anxiety and fear in rats, recovers adequate reactions and the orientative-trying behavior, and lessens aggressiveness. Mexidol extends life span of mice in acute hypoxic conditions. Mexidol is highly competitive with diazepam as an anti-stress agent and excels it as an anti-hypoxic agent; in contrast to diazepam, mexidol does not cause sedation and myorelaxation.

[Combined action of mexidol and non-narcotic analgesics on pain thresholds and emotional stress behavior in animals].

The influence of non-narcotic analgesics analgin and pentalgin in the basic pharmacological effects of diazepam and mexidol has been studied in outbred male albino rats. It is established that both analgesics do not influence the activity of diazepam. At the same time, they potentiate the analgesic action of mexidol without influencing its antistress action and not inducing any side effects.

[Effect of typical and atypical anxiolytics on the behavior and electrophysiological parameters of rats with model cerebrovascular pathology].

The influence a series of anxiolytics (tranquilizers) on behavioral disturbances was studied in outbread white male rats with cerebrovascular pathology modeled by ligation of common carotid arteries. All studied anxiolytics (diazepam, buspirone, mexidol) exhibited more of less pronounced protective action with respect to the pathology studied. The most significant protective effect was produced by the atypical anxiolytic mexidol.

[Instrumental evaluation of sensory thresholds in subjects with different pain sensitivity].

Will the aid of a modified apparatus the authors determined the sensory thresholds of tactile, and pain sensitivity, and the limit of pain tolerance. Subject to measurement were 500 persons. By the nature of the initial high sensitivity (minor thresholds), moderate (medium) and low (major thresholds) ones.

[Antioxidant Mexidol premedication of patients with periodontitis during antihomotoxic therapy].

The tranquilizing effect of antioxidant mexydol on 95 patients with chrconic generalized parodontitis against a background of various somatic diseases was evaluated. The anxiety and the efficiency of premedication were accessed according to Korach's and Spilberger's scales and according to the special psychological questionnaire. The quantitative characteristics of premedication were given baised on the psychological tests results.

[The use of antihomotoxic therapy in dentistry].

Efficacy of traumel C is assessed in patients with various maxillofacial inflammations. Sixty-nine patients with diseases of the buccal mucosa (aphthous stomatitis, herpes labialis, and perlèches), periodontal tissues, and painful syndrome after dental canal filling were treated. Applications of the drug were administered to patients with diseases of the buccal mucosa and slight or medium-severe periodontitis.

[A comparison of the effect of tranquilizers in experiments and clinical practice].

Experimental and clinical study of the analgesic effects of mebicar and benzodiazepine series tranquilizers (sibazon and chlozepid) and their combinations with non-narcotic analgesics (amidopyrin, pyranal) or local anesthetic lidocaine has demonstrated a more marked effect of benzodiazepine derivatives on pain sensitivity thresholds as against mebicar. Tranquilizer combinations with other analgesics helped define the optimal premedication variants: benzodiazepine derivative augment analgesic activity whereas mebicar potentiates lidocaine effect.

[The use of fluorine-containing coatings for isolating fissures of the molars and premolars to prevent caries].

Experimental and clinical investigations were performed to assess the caries-preventing potencies of hermetic covering with Epoxylite-9075 (USA) and vitacryl (USSR) insulating the intact fissures in molars and premolars. Intact sheathing is capable of protecting the tooth against caries for a long time. Fluoride as a component of the material increased the enamel caries-resistance.