How do bipolar disease states affect positive and negative emotion processing? Insights from a meta-analysis on the neural fingerprints of emotional processing.

Background: Functional magnetic resonance imaging studies on emotion processing in patients with bipolar disorder (BD) show hyperactivity of limbic-striatal brain areas and hypoactivity in inferior frontal areas compared to healthy participants. However, heterogeneous results in patients with different disease states and different valences of emotional stimuli have been identified.

Methods: To integrate previous results and elucidate the impact of disease state and stimulus valence, we conducted a systematic literature search for journal articles in the Web of Science Core Collection including MEDLINE databases and employed a coordinate-based-meta-analysis of functional-MRI studies comparing emotion processing in BD-patients with healthy participants using seed-based d mapping (SDM) to test for between-subjects-effects.

Interactions within the social brain: Co-activation and connectivity among networks enabling empathy and Theory of Mind.

Empathy and Theory of Mind (ToM) have classically been studied as separate social functions, however, recent advances demonstrate the need to investigate the two in interaction: naturalistic settings often blur the distinction of affect and cognition and demand the simultaneous processing of such different stimulus dimensions. Here, we investigate how empathy and ToM related brain networks interact in contexts wherein multiple cognitive and affective demands must be processed simultaneously. Building on the findings of a recent meta-analysis and hierarchical clustering analysis, we perform meta-analytic connectivity modeling to determine patterns of task-context specific network changes.