Publications by authors named "Lara Rinaldi"
Article Synopsis
- - Mild traumatic brain injury (mTBI) patients can sometimes have detectable brain lesions via CT scans, but many don't show any visible issues, highlighting the need for better detection methods.
- - The study examined 13 different proteins to identify which ones could help differentiate between mTBI patients with and without brain lesions; ultimately, four proteins (H-FABP, IL-10, S100B, and GFAP) were found to be effective, with H-FABP showing the highest performance.
- - Combining H-FABP and GFAP into a blood biomarker panel improved detection accuracy for CT-positive patients, with additional success when adding IL-10, achieving 100% sensitivity and a specificity of up to
Traumatic brain injury is a common event where 70%-90% will be classified as mild TBI (mTBI). Among these, only 10% will have a brain lesion visible via CT scan. A triage biomarker would help clinicians to identify patients with mTBI who are at risk of developing a brain lesion and require a CT scan.
View Article and Find Full Text PDFThe majority of patients with mild traumatic brain injury (mTBI) will have normal Glasgow coma scale (GCS) of 15. Furthermore, only 5%-8% of them will be CT-positive for an mTBI. Having a useful biomarker would help clinicians evaluate a patient's risk of developing intracranial lesions.
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