Publications by authors named "Lara Melo"
Metformin, a biguanide derived from Galega officinalis, was first synthesized by Werner and Bell in 1922. Metformin was approved for the treatment of diabetes by the US Food and Drug Administration in 1994. It has since become the most widely used oral antidiabetic agent.
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- The study investigates whether a liberal or restrictive blood transfusion strategy is more effective in reducing all-cause mortality in patients with anemia due to acute myocardial infarction (AMI).
- Through a meta-analysis of three randomized controlled trials involving over 4,200 participants, it found no significant differences in mortality or other major health outcomes after 30 days between the two transfusion approaches.
- The variability in blood transfusion use among patients receiving a restrictive strategy may account for the differing results across the trials, suggesting that individual treatment plans might need to be tailored based on patient needs.
Article Synopsis
- There’s a debate about how long patients with heart problems should take two types of medicine together, called dual antiplatelet therapy (DAPT).
- Researchers wanted to see how effective and safe different lengths of DAPT are for patients who have serious heart issues and receive a special procedure to help their hearts.
- They found that taking DAPT for just 1 month followed by another medicine might reduce serious bleeding, but didn't change the number of heart problems compared to taking DAPT for 12 months.
Introduction: The rising prevalence of psychiatric disorders has resulted in a significant increase in the use of antipsychotic medications. These agents may prolong the corrected QT interval (QTc), running the risk of precipitating ventricular arrhythmias, notably Torsades de Pointes (TdP). Current recommendations vary regarding the optimal approach to safe prescribing practices and QTc surveillance for antipsychotics.
View Article and Find Full Text PDFFamilial Mediterranean fever (FMF) is a hereditary, autosomal recessive auto-inflammatory disorder characterized by recurrent attacks of fever and serositis. While arthritis, pleuritis, peritonitis, and pericarditis are common in FMF, large pericardial effusions with cardiac tamponade as a sequelae of FMF are considered rare. We report a case of an 83-year-old female with a history of FMF who presented with chest pain.
View Article and Find Full Text PDFCommotio cordis is a rare, however, potentially fatal, cardiovascular phenomenon arising from direct chest wall trauma, causing sudden cardiac arrest and potentially death. It is primarily seen in young athletes who participate in contact and organized sports. Though debated, the cause of commotio cordis is believed to involve specific timing of chest impact during ventricular electrical activity leading to severe arrhythmic events.
View Article and Find Full Text PDFObjective: To assess intermittent abdominal pain in IgA vasculitis patients and its relation to demographic data, clinical manifestations and treatments.
Methods: A retrospective cohort study included 322 patients with IgA vasculitis (EULAR/PRINTO/PRES criteria) seen at the Pediatric Rheumatology Unit in the last 32 years. Sixteen patients were excluded due to incomplete data in medical charts.