Publications by authors named "Lara Kim Brackmann"
Introduction: Long non-coding ribonucleic acids (lncRNAs) are involved in the cellular damage response following exposure to ionizing radiation as applied in radiotherapy. However, the role of lncRNAs in radiation response concerning intrinsic susceptibility to late effects of radiation exposure has not been examined in general or in long-term survivors of childhood cancer with and without potentially radiotherapy-related second primary cancers, in particular.
Methods: Primary skin fibroblasts (n=52 each) of long-term childhood cancer survivors with a first primary cancer only (N1), at least one second primary neoplasm (N2+), as well as tumor-free controls (N0) from the KiKme case-control study were matched by sex, age, and additionally by year of diagnosis and entity of the first primary cancer.
Article Synopsis
- Childhood cancer survivors (CCS) face high risks for long-term health issues, particularly secondary primary neoplasms (SPN), prompting the development and validation of a self-administered questionnaire for assessing past cancer treatments and late effects.
- The study involved comparing self-reported cancer treatments from CCS with their medical records, revealing perfect agreement for chemotherapy among SPN survivors and varying levels of agreement for other treatments across different groups.
- Results indicated that CCS who received chemotherapy were less likely to be overweight, but had a higher likelihood of thyroid diseases and hypercholesterolemia, highlighting complex health outcomes linked to their treatment history.
Article Synopsis
- This study investigates expression variability (EV) in primary fibroblasts from childhood cancer survivors and cancer-free controls after exposure to ionizing radiation, focusing on distinguishing the effects across different donor groups.
- Researchers analyzed skin fibroblasts from 156 donors: 52 with first primary neoplasms (N1), 52 with multiple primary neoplasms (N2+), and 52 cancer-free controls (N0), exposing them to varying doses of X-rays and identifying gene responses to radiation.
- Key findings include the identification of 22 genes with significant EV variation linked to ionizing radiation, particularly noting unique gene responses in cancer-free individuals (N0) and higher variability in cancer survivors (N2+) related to cell
Article Synopsis
- * A study compared CCS with first primary neoplasms (FPN) and subsequent second primary neoplasms (SPN) to cancer-free individuals, revealing that CCS had higher rates of various diseases and were more likely to take regular medications.
- * Despite having healthier metrics such as less smoking and lower rates of being overweight, CCS had lower levels of physical activity compared to controls; specific health concerns were linked to their cancer status, particularly thyroid and cholesterol issues.
Background: The etiology and most risk factors for a sporadic first primary neoplasm in childhood or subsequent second primary neoplasms are still unknown. One established causal factor for therapy-associated second primary neoplasms is the exposure to ionizing radiation during radiation therapy as a mainstay of cancer treatment. Second primary neoplasms occur in 8% of all cancer survivors within 30 years after the first diagnosis in Germany, but the underlying factors for intrinsic susceptibilities have not yet been clarified.
View Article and Find Full Text PDFBackground: Therapy for a first primary neoplasm (FPN) in childhood with high doses of ionizing radiation is an established risk factor for second primary neoplasms (SPN). An association between exposure to low doses and childhood cancer is also suggested; however, results are inconsistent. As only subgroups of children with FPNs develop SPNs, an interaction between radiation, genetic, and other risk factors is presumed to influence cancer development.
View Article and Find Full Text PDFIntroduction: Infections may play a role in the etiology of childhood cancer and immunizations may be protective because vaccinations stimulate the immune system. Observational studies reported inconsistent associations between vaccination and risk of childhood cancer. Since a synthesis of the evidence is lacking, we conducted a meta-analysis stratified by histological and site-specific cancer.
View Article and Find Full Text PDFThe study aims to investigate to what extent school- and leisure time-related factors are associated with sedentary behavior during school in German and Irish children and adolescents. The study based on a sample of 198 children and adolescents surveyed in 2015. Sedentary and activity behavior were measured using the activPAL physical activity monitor.
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- The study investigates how human fibroblasts respond to ionizing radiation by analyzing gene expression changes at two time points post-exposure (2 hours and 4 hours) after being irradiated with different doses of X-rays (2Gy and 0.05Gy).
- It uses RNA sequencing to identify differentially expressed genes and perform pathway analyses to understand the biological effects and mechanisms behind radiation exposure.
- Findings show that more genes were differentially expressed at the 4-hour mark, especially with high-dose radiation, affecting pathways related to cancer signaling and metabolism, while low-dose exposure didn’t produce significant changes at either time point.
Aim of this study was to describe the proportion of hypertension among Zanzibari of different age-groups and to detect possible correlates of this non-communicable disease. In 2013 a cross-sectional survey was conducted in Unguja Island, Zanzibar. A total of 235 randomly selected households, including 1,229 (2 to 95 years) eligible study participants, were examined.
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