Reduced brain white matter integrity in trichotillomania: a diffusion tensor imaging study.

Context: Trichotillomania is an Axis I disorder characterized by repetitive, pathological hair pulling.

Objective: To assess the integrity of white matter tracts in subjects with the disorder.

Design: Between-group comparison using permutation cluster analysis, with stringent correction for multiple comparisons.

Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study.

Background: Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking.

Aims: To investigate grey and white matter abnormalities over the whole brain in patients with trichotillomania.

Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder.

Objective: Obsessive-compulsive disorder (OCD) is highly heritable. Attempts to delineate precise genetic contributions have met with limited success. There is an ongoing search for intermediate cognitive brain markers (endophenotypes) that may help clarify genetic contributions.