Publications by authors named "Lapinska G"
Article Synopsis
- Clinical data on primary central nervous system lymphoma (PCNSL) often excludes frail patients, and recent challenges in diagnosis and treatment arose due to the COVID-19 pandemic, especially concerning pneumonia risks with certain treatments.
- The study reports on the R-MIV induction regimen, which includes intensive methotrexate, showing a high overall response rate of 73% among 64 patients, and low severe hematological toxicity rates.
- There were three treatment-related fatalities, but most patients were eligible for further consolidation treatment, indicating that R-MIV is both effective and safe for PCNSL patients, even amidst the pandemic challenges.
Article Synopsis
- Primary mediastinal B-cell lymphoma (PMBL) has a high cure rate of 85-95%, with various treatment regimens including RCHOP and DAEPOCH-R; this study examined a protocol involving aggressive immunochemotherapy and intermediate-dose methotrexate.
- The study involved 124 patients, with a median follow-up of 9 years, showing impressive 5-year overall survival (94%) and progression-free survival (92%), influenced by PET-CT results post-chemotherapy.
- The intensive treatment showed low rates of severe side effects (0.8% treatment-related mortality) and late toxicities (2.4% for second malignancies and cardiotoxicity), indicating its effectiveness and safety in young
Objective: The objective of this study was to identify the optimal cut-off value of prostate specific antigen (PSA) to assess the extent of the disease in [Ga]Ga-PSMA-11 PET/CT study in patients after radical prostatectomy.
Materials And Methods: Retrospective analysis was performed on a group of 215 patients who underwent a [Ga]Ga-PSMA-11 PET/CT examination because of suspected recurrence after radical prostatectomy. Patients were divided into four groups: 1, no active lesions suggesting recurrence (n = 92); 2, suspected isolated local recurrence (n = 19); 3, oligometastatic disease (n = 82); and 4, polymetastatic disease (n = 22).
We are reporting a case of a 55-year-old woman who was diagnosed as having a non-functioning pancreatic neuroendocrine neoplasm (NF-PNEN), the World Health Organization (WHO) low grade (G1) with liver metastases. In the staging process the positron emission tomography - computed tomography with Fluorine-18-Fluorodeoxyglucose (F-FDG PET-CT) and spiral CT then the gallium-DOTA-octreotate positron emission tomography - computer tomography (⁶⁸Ga-DOTATATE PET-CT) shown difference in burden of disease. In first line therapy, everolimus (Afinitor®, Novartis Pharma GmbH, Germany) at the oral dose of 10 mg once daily and octreotide long-acting release (Sandostatin LAR®) 30 mg i.
View Article and Find Full Text PDFBackground: Multidrug chemotherapy increases the efficacy of the treatment, but at the same time rises its cardiotoxicity. The majority of cardiac complications are caused by anthracyclines.Radiation therapy may intensify cardiotoxicity.
View Article and Find Full Text PDFBackground: Positron emission tomography (PET) combined with computer tomography (CT) using (68)Ga-DOTATATE is a promising method for the evaluation of patients with recognised or suspected neuroendocrine tumours (NET). The aim of this study was to assess the diagnostic value of (68)Ga-DOTATATE PET/CT in the visualisation of the expression of somatostatin receptors (SSTR) and identification of new lesions.
Material And Methods: Between December 2009 and January 2011 ninety-seven patients with confirmed (88 cases) or suspected (9 cases) NET underwent (68)Ga DOTATATE PET/CT.
Bone scan remains the most frequently requested investigation in any nuclear medicine department. The main reason for this is the exquisite sensivity of the bone scan for lesion detection, combined with clear visualisation of the whole skeleton. The isotope bone scan is now generally accepted as initial investigation of choice in the search for bone metastases from most tumours.
View Article and Find Full Text PDFThe diagnostic value of bone scintigraphy in patients with back pain.
Ortop Traumatol Rehabil
April 2004
Background. The aim of the study was retrospective evaluation of planar bone scintigraphy in the diagnostics of back pain syndrome.
Material and methods.