Publications by authors named "Lanzhu Peng"
Some colorectal cancer patients have experienced normal epithelial transformation into inflammatory and tumor states, but the molecular basis still needs to be further determined. The expression levels of SIX4 are gradually increased in dextran sodium sulfate (DSS) and azoxymethane (AOM)/DSS-induced colonic epithelial inflammation and tumors, respectively, in mice. Targeting SIX4 alleviates intestinal inflammation occurrence and reduces adenoma formation in mice.
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- - The study focuses on miR-2110, a microRNA identified in Epstein-Barr virus-positive nasopharyngeal carcinoma (NPC), and its role in suppressing NPC metastasis through various molecular mechanisms.
- - Researchers found that increasing miR-2110 levels reduced NPC cell migration, invasion, and metastasis by targeting and lowering the protein FGFR1, which in turn stabilized PTEN and inhibited signaling pathways that promote metastasis.
- - Cinobufotalin (CB), a potential treatment, was shown to enhance miR-2110 expression, further contributing to the inhibition of NPC metastasis, while lower levels of miR-2110 were associated with worse outcomes in patients' lymph node metastasis
CCDC65 is a member of the coiled-coil domain-containing protein family and was only reported in gastric cancer by our group. We first observed that it is downregulated in lung adenocarcinoma based on the TCGA database. Reduced CCDC65 protein was shown as an unfavorable factor promoting the clinical progression in lung adenocarcinoma.
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