A new species of Micrapate (Insecta: Coleoptera: Bostrichidae) from Brazil, with a key to Brazilian species.

Micrapate spinula Liu, sp. nov., is described from the cerrado savanna biome of Brazil (Mato Grosso do Sul and Minas Gerais), together with information on its biology and natural enemies.

Feasibility and safety of percutaneous intramyocardial septal cryoablation: A canine model with 6-month follow-up.

Echocardiography-guided percutaneous intramyocardial septal radiofrequency ablation (PIMSRA, Liwen procedure) is a novel treatment option for hypertrophic obstructive cardiomyopathy (HOCM). The safety and feasibility of using this procedure for cryoablation are unknown. We aimed to investigate the feasibility and safety of echocardiography-guided percutaneous intramyocardial septal cryoablation (PIMSCA) for septal thickness reduction in a canine model.

The first Asian species of Polycaon Castelnau, and a new montane species of Melalgus Dejean from China (Coleoptera: Bostrichidae: Polycaoninae).

We describe Polycaon sinensis sp. n., the first Asian species of this otherwise American genus, and Melalgus plesiobatillus sp.

Development of polyanion-metal ion solution systems to overcome phospholipids-related matrix effects in LC-MS/MS-based bioanalysis.

Phospholipids-related matrix effects are a major source impacting the reproducibility of analyte quantification in LC-MS/MS-based bioanalysis. This study intended to evaluate different combinations of polyanion-metal ion based solution system for phospholipids removal and elimination of matrix effects in human plasma. Blank plasma samples or plasma samples spiked with model analytes were proceeded with different combinations of polyanions (dextran sulfate sodium (DSS) and alkalized colloidal silica (Ludox)) and metal ions (MnCl, LaCl, and ZrOCl) followed with acetonitrile-based protein precipitation.

A Validated UHPLC-MS/MS Method to Quantify Eight Antibiotics in Quantitative Dried Blood Spots in Support of Pharmacokinetic Studies in Neonates.

Objectives: Conduction of pharmacokinetic (PK) study in pediatric patients is challenging due to blood sampling limits. The dried blood spots (DBS) method represents a potential matrix for microsampling in support of PK studies in children. Herein, we used the Capitainer qDBS device to develop a DBS method that can collect an exact 10 µL volume of blood on a paper card.

Defining Exposure Predictors of Meropenem That Are Associated with Improved Survival for Severe Bacterial Infection: A Preclinical PK/PD Study in Sepsis Rat Model.

Background: The pharmacokinetic/pharmacodynamic (PK/PD) index of carbapenems that best correlates with in vivo antimicrobial activity is percent time of dosing interval in which free drug concentration remains above MIC (%fT > MIC), while the magnitudes of the PK/PD index of carbapenems remains undefined in critically ill sepsis patients. Methods: A sepsis rat model was first developed by comparing the survival outcomes after intraperitoneal injection of different inoculum size (1−10 × 107 CFU) of Pseudomonas aeruginosa ATCC9027 (MIC = 0.125 mg/L) in neutropenic rats.

An annotated synopsis of the powder post beetles (Coleoptera: Bostrichidae) of Mainland China.

An updated and annotated synopsis of the family Bostrichidae of mainland China is presented, including sixty-eight species belonged to seven subfamilies (including eight tribes), and twenty-nine genera. Thirteen species are new records for mainland China, and numerous new provincial records are given. Four species, Dolichobostrychus yunnanus Lesne, 1913, Heterobostrychus ambigenus Lesne, 1920, Sinoxylon eucerum Lesne, 1932 and S.

An UPLC-PDA assay for simultaneous determination of seven antibiotics in human plasma.

Appropriate antibiotic dosing in critically ill patients requires concentration monitoring due to the occurrence of pathophysiological changes and frequent extracorporeal therapy that could significantly alter the normal pharmacokinetics of drugs. Herein, we describe an ultra-performance liquid chromatography with photodiode array (UPLC-PDA) for the simultaneous concentration determination of seven frequently used antibiotics (meropenem, cefotaxime, cefoperazone, piperacillin, linezolid, moxifloxacin, and tigecycline) in plasma from critically ill patients. The analytes were extracted from 200 μL human plasma by the addition of methanol for protein precipitation.

Revision of the genus Xylodrypta Lesne 1901 (Coleoptera: Bostrichidae: Bostrichinae: Xyloperthini) with a new species and a key to species.

We revise the monospecific bostrichid genus Xylodrypta Lesne 1901, and describe a new species, X. lanna Liu Beaver from Thailand and Laos. A key is given to distinguish the two species of Xylodrypta.

Long noncoding RNAs expression profile and functional networks in rheumatoid arthritis.

The modifying effects of long noncoding RNAs (lncRNAs) in rheumatoid arthritis (RA) recently have drawn much attention; however, the underlying mechanisms remain largely unknown. Herein, we aim to investigate the expression profile of lncRNAs in RA and identify promising targets for RA diagnosis and treatment. Microarray screening and real-time PCR of lncRNAs were performed by use of serum samples from 3 RA patients and 3 healthy controls.

Long noncoding RNA SNHG20 promotes gastric cancer progression by inhibiting p21 expression and regulating the GSK-3β/ β-catenin signaling pathway.

Recent studies have indicated that long non-coding RNAs (lncRNAs) play important regulatory roles in tumor development and progression. However, the contribution of small nucleolar RNA host gene 20 (SNHG20) to gastric cancer development remains largely unknown. The aim of the study is to investigate the functional significance of SNHG20 involved in gastric cancer (GC) progression.