Publications by authors named "Lanyu He"
Article Synopsis
- Cancer is a leading cause of death globally, and effective drug development is essential, with traditional Chinese medicine (SI) showing promising anti-cancer effects whose mechanisms are not fully understood.
- Researchers used systems pharmacology to identify active compounds in SI and construct networks to analyze their targets and pathways related to cancer, resulting in the discovery of seven key compounds and 187 targets.
- Experimental tests confirmed that four of these compounds can reduce cell proliferation and increase apoptosis in certain cancer cell lines, providing a basis for further research and potential drug development in modern medicine.
[Preparation of hispidulin chitosan microsphere and its antiproliferation effect ].
Zhongguo Zhong Yao Za Zhi
July 2018
Hispidulin(HPDL) chitosan microspheres were prepared in this study to deliver HPDL to the lesion sitevia intravenous injection, and further evaluate their anticancer effects in vitro and the growth inhibition effect on A549 cells spheroids. HPDL chitosan microspheres were prepared by emulsion crosslinking method with chitosan as a drug carrier and the amount of HPDL was determined by high performance liquid chromatography (HPLC). The morphology of microspheres was observed under laser scanning confocal microscope.
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