Publications by authors named "Lanxing Li"
Non-coding RNA notations, regulations and interactive resources.
Funct Integr Genomics
November 2024
Article Synopsis
- Non-coding RNAs (ncRNAs) play crucial roles in gene expression and cellular regulation, but many still lack a fully understood function despite extensive research.
- The review highlights the need for a unified system to categorize and integrate over 50 types of characterized ncRNAs and their diverse functions.
- It introduces the ncRNA Hub web portal as a resource for detailed ncRNA information and bioinformatics tools, aiming to enhance the understanding and standardization of ncRNA research.
PD-1/PD-L1 Inhibitor Plus Chemotherapy Versus PD-1/PD-L1 Inhibitor in Microsatellite Instability Gastrointestinal Cancers: A Multicenter Retrospective Study.
JCO Precis Oncol
March 2023
Purpose: To investigate the efficacy of PD-1/PD-L1 inhibitors plus chemotherapy versus anti-PD-1/PD-L1 monotherapy in advanced microsatellite instability (MSI)/mismatch repair-deficient (dMMR) gastrointestinal cancers.
Methods: We retrospectively recruited patients with MSI/dMMR gastrointestinal cancer who received anti-PD-1/PD-L1 with or without chemotherapy and compared objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS) of PD-1/PD-L1 inhibitor plus chemotherapy (chemo-anti-PD-1/PD-L1 group) and PD-1/PD-L1 inhibitor alone (anti-PD-1/PD-L1 group). Propensity score-based overlap weighting analysis was conducted to adjust the baseline covariable imbalance.
Background: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) participates in tumor immune escape by delivering inhibitory signals to T cells. The purpose of this article was to assess the prognostic value of TIGIT and its immunological function in solid cancers.
Methods: Three databases were searched for relevant articles.