Synthesis, characterization and anticancer, antibacterial activities of pentacyclic triterpenoid glycoside derivatives.

As a kind of glycoside, pentacyclic triterpenoid saponins have good biological activities, such as anticancer, antibacterial, antiviral and hypoglycemic effects [1]. In this paper, twenty-four pentacyclic triterpenoid derivatives, including twelve monosaccharide derivatives, were designed and synthesized. The anticancer effect and antibacterial activities of all compounds were evaluated.

Two new phenolic glycosides from the roots of (L.) Goldblatt & Mabb and their cytotoxic activity.

Two new phenolic glycosides, Diplostephioside D () and Diplostephioside E () together with ten known phenols (-) were isolated from the dried roots of (L.) Goldblatt & Mabb. Among them, compounds - have not been reported previously from the family Iridaceae.

Research, Development and Pharmacological Activity of Sinomenine and Its Derivatives.

In this manuscript, the resource distribution, pharmacological activity, pharma-cokinetics of sinomenine and the structure, synthesis, biological activity and mechanism of sinomenine derivatives reported from 2000 to December 2023 were reviewed. The lit-erature was retrieved through Web of Science, PubMed, Science Direct, SciFiner Scholar and other websites. Sinomenine belongs to isoquinoline alkaloids and was extracted from the Chinese herb Sinomenium acutum root.

Synthesis, characterization and antiproliferative effects of isosteviol derivatives.

Nineteen isosteviol derivatives were designed and synthesized by C-16, C-19 and D-ring modifications of isosteviol. These compounds were screened for their cytotoxic activities against Hela and A549 cells . Among them, the inhibitory effect of compounds and on Hela cells was comparable to that of the positive control gefitinib, and the compounds (IC=7.

Two new stilbene glucosides and a new benzoic acid derivative from .

Two new stilbene glucosides, -3,5-dihydroxy-4-methoxystilbene 3--D-glucopyranoside (), -3,5-dihydroxy-4-methoxystilbene 3--D-glucopyranoside (), one new benzoic acid derivative, -4-hydroxy-3-hydroxymethyl-2-butenyl benzoate 4--D-glucopyranoside (), and four known compounds () were isolated from L. The structures of these compounds were elucidated on the basis of spectral data. Anti-inflammatory effects of compounds () were evaluated in terms of inhibition on production of NO, TNF-α and IL-6 in LPS-induced RAW 264.