Clinical practice guideline for the physiotherapy of patients with whiplash-associated disorders.

Study Design: A clinical practice guideline.

Objectives: To assist physiotherapists in decision making and to improve the efficacy and uniformity of care for patients with whiplash-associated disorders Grades I and II.

Summary Of Background Data: Whiplash constitutes a considerable problem in health care.

Whiplash: assessing the validity of diagnostic tests in a cervical sensory disturbance.

Objective: To determine the ability of two diagnostic tests that examine sensory disturbance in whiplash patients to discriminate between 'extreme' groups.

Background: The neuromuscular theories have been accepted as explanations of the symptoms after a whiplash injury. Dutch manual therapists often use the diagnostic tests under study to diagnose and treat sensory disturbances after such an injury.

[Effect of alcoholic hyperlipoproteinemias on the deformability and viscosity of erythrocytes].

This pilot study set out to evaluate the influence of the metabolic disorder due to acute alcohol toxicity on red blood cell (RBC) deformability. RBC deformability was measured optoelectronically by microcomputer-assisted polymicroviscometry (filtrometry). Chronic alcoholic patients (n = 12) with transient haemolytic anaemia, jaundice and hyperlipoproteinaemia were studied during the acute and the remittent phase of alcoholic disease.

[Oral theophylline therapy for dyspnea].

With regard to special situations in severe dyspnea 10 patients with reversible airway obstruction were studied to verify the effect of oral and systemic application of 193,2 mg Theophyllinmonohydrat and 46,8 mg Aethylendiamin as customary in the trade injection fluid (Euphyllin) on blood levels. In comparison both medications are bioaquivalent . The oral application yields with duration serum concentrations of theophylline higher than 5 mg/l but less than the postulated therapeutic levels from 10--20 mg/l.

[Pathologic fluidity, glycohemoglobin and erythrocyte metabolism disorder in Fontaine II diabetic macroangiopathy].

This pilot study set out to evaluate the influence of metabolic disorders due to diabetes mellitus on red blood cell (RBC) substrates, deformability and glycohaemoglobin (HbA1) levels. RBC deformability was measured optoelectronically by microcomputer-assisted polymicroviscometry (filtrometry) following separation of RBC into old (dense) and young (buoyant) fractions by means of density-layer centrifugation. 20 adult patients with type II diabetes mellitus associated with Fontaine II macroangiopathy underwent RBC investigations before and after diabetic therapy.

Biorheological and metabolic dysfunctions of density-fractionated erythrocytes in diabetics with peripheral vascular disease.

Preliminary communications are presented about a serial study of biorheological and metabolic dysfunctions of density-fractionated erythrocytes (RBC) in diabetics with vaso-occlusive disorders. The study aimed at evaluating the influence of metabolic disorder due to diabetes mellitus on RBC substrates, deformability and glycohaemoglobin (HbA1) levels. The peak HbA1 level served to confirm the duration of serum metabolic disorder due to diabetic crisis.

Cyclic nucleotide metabolism in experimental bronchial constriction in rabbits.

In anesthetized, spontaneously breathing rabbits, intratracheally administered isotonic saline, acetylcholine (Ach) and histamine (His) induced an increase of airway resistance up to 183, 571, and 312%, respectively, compared with untreated controls. This was accompanied by a decrease of the arterial pO2. Bilateral cervical vagotomy led to nearly complete inhibition of the saline- and Ach-induced bronchoconstriction, whereas the His effect was only reduced to 202%.

Alterations of pulmonary vascular resistance and pulmonary cyclic nucleotide metabolism in the hypoxic pig.

Hypoxia leads to an elevation of the pulmonary vascular resistance (pvR) in pigs. This alteration of the hemodynamic was accompanied by a slight increase of intraparenchymatous concentrations of cyclic GMP (cGMP), while cycle AMP (cAMP) levels were not different from values, measured during normoxia. beta-adrenergic agents are potent inhibitors of the hypoxia induced vasoconstriction.

[Propranolol and pindolol in chronic obstructive lung disease (author's transl)].

The effects of 5 mg pindolol and 100 mg propranolol on the airway resistance were compared with a placebo in an inter-individual double blind trial in eight patients with chronic obstructive lung disease. Six hours after drug administration the patients inhaled two puffs of fenoterol (0.4 mg) from a metered aerosol to test the reversibility of the bronchoconstrictive effect.

[The effect of dopamin on the microcirculation on the pancreas in hemorrhagic-shock (author's transl)].

The influence of Dopamine on microcirculation during hemorrhagic shock was investigated by means of the pancreas chamber technique (HEISIG, 1967). Parameter of microcirculation was the corpuscular flow velocity measured with the "flying spot" method. Simultaneously arterial and venous blood pressure, heart rate, blood gases and pH-status were registered.