Field migration of veterinary antibiotics via surface runoff from chicken-raising orchard in responding to natural rainfalls.

Knowledge on runoff transport of manure-sourced antibiotics from farmland soil to aquatic environment is limited due to complexity of hydrological regime and pathways. This study monitored natural rainfalls in sloping orchard plots with free-range chickens, with an attempt to investigate the migration characteristics of typical antibiotics via surface runoff as well as the impact of manure presence. Results showed that rainstorms continuously carried away antibiotics in surface runoff and all target antibiotics including those with high affinities to soil were detected at the beginning of runoff production.

Biopesticides as a promising alternative to synthetic pesticides: A case for microbial pesticides, phytopesticides, and nanobiopesticides.

Over the years, synthetic pesticides like herbicides, algicides, miticides, bactericides, fumigants, termiticides, repellents, insecticides, molluscicides, nematicides, and pheromones have been used to improve crop yield. When pesticides are used, the over-application and excess discharge into water bodies during rainfall often lead to death of fish and other aquatic life. Even when the fishes still live, their consumption by humans may lead to the biomagnification of chemicals in the body system and can cause deadly diseases, such as cancer, kidney diseases, diabetes, liver dysfunction, eczema, neurological destruction, cardiovascular diseases, and so on.

Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities.

Neurodegenerative and neuronal-related diseases are major public health concerns. Human vulnerability to neurodegenerative diseases (NDDs) increases with age. Neuronal hormones and neurotransmitters are major determinant factors regulating brain structure and functions.

Modelling approaches for linking the residual concentrations of antibiotics in soil with antibiotic properties and land-use types in the largest urban agglomerations in China: A review.

Persistently high concentrations of antibiotics have been reported in soils worldwide due to the intensive use of veterinary antibiotics, and continuous adsorption and transport of various antibiotics in soils occur, posing a significant threat to the environment and human health. This study systematically reviews the spatial distribution and ecological risk of four commonly detected antibiotic residues in soil in China, including sulphonamides (SAs), fluoroquinolones (FQs), tetracyclines (TCs) and macrolides (MLs), using various models, such as redundancy analysis (RDA), principal coordinate analysis (PCoA) and structural equation modelling (SEM). Antibiotic residual concentration data were obtained from relevant repositories and the literature.

Transport of Veterinary Antibiotics in Farmland Soil: Effects of Dissolved Organic Matter.

The application of manure as a fertiliser to farmland is regarded as a major source of veterinary antibiotic (VA) contamination in the environment. The frequent detection of such emerging contaminants and their potential adverse impacts on the ecosystem and human health have provoked increasing concern for VA transport and fate. Extrinsic dissolved organic matter (DOM) may be introduced into farmland soil along with Vas, and thus exert significant effects on the transport of VAs via hydrological processes upon rainfall.

Therapeutic drugs for SARS-CoV-2 treatment: Current state and perspective.

The disease caused by viral pneumonia called severe acute respiratory syndrome coronavirus type-2 (SARS-CoV-2) declared by the World Health Organization is a global pandemic that the world has witnessed since the last Ebola epidemic, SARS and MERS viruses. Many chemical compounds with antiviral activity are currently undergoing clinical investigation in order to find treatments for SARS-CoV-2 infected patients. On-going drug-drug interaction examinations on new, existing, and repurposed antiviral drugs are yet to provide adequate safety, toxicological, and effective monitoring protocols.