Engineering Docetaxel Micelles for Enhanced Cancer Therapy Through Intermolecular Forces.

Docetaxel has exhibited excellent therapeutic effects in cancer treatment; however, its hydrophobicity, short blood circulation time, and high blood toxicity restrict its clinical application. The use of mPEG-PLA micelles to deliver docetaxel into the body has been verified as an effective approach to enhance its therapeutic efficacy. However, mPEG-PLA micelles are easily disassembled in the bloodstream, which can easily lead to premature drug release.

Developing and validating a predictive model of delivering large-for-gestational-age infants among women with gestational diabetes mellitus.

Background: The birth of large-for-gestational-age (LGA) infants is associated with many short-term adverse pregnancy outcomes. It has been observed that the proportion of LGA infants born to pregnant women with gestational diabetes mellitus (GDM) is significantly higher than that born to healthy pregnant women. However, traditional methods for the diagnosis of LGA have limitations.

Effect of Comprehensive Nursing on the Recovery of Gastrointestinal Function in Patients Undergoing Abdominal Operation.

Objective: The objective is to explore the effect of comprehensive nursing on the recovery of gastrointestinal function in patients undergoing an abdominal operation.

Methods: Sixty patients undergoing abdominal surgery in our hospital from January 2019 to April 2021 were enrolled. The patients were arbitrarily assigned into control group and research group.

Two multi-temporal datasets to track debris flow after the 2008 Wenchuan earthquake.

We provide two datasets for tracking the debris flow induced by the 2008 Wenchuan Mw 7.9 earthquake on a section of the Longmen mountains on the eastern side of the Tibetan plateau (Sichuan, China). The database was obtained through a literature review and field survey reports in the epicenter area, combined with high-resolution remote sensing image and extensive data collection and processing.

Impact of inflammatory factors, hemoglobin A1c, and platelet parameters in gestational diabetes mellitus.

Purpose: The aim of this study was to evaluate the relationship among inflammatory cytokines including hypersensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6), glycated hemoglobin A1c (HbA1c), and platelet distribution width (PDW) in women with gestational diabetes mellitus (GDM).

Methods: Data on 191 pregnant women (96 women with GDM; 95 healthy controls) were extracted from routine prenatal examination records in Nanjing, China. Fasting concentrations of hs-CRP, IL-6, HbA1c, blood cell indices, and glucose at 24-28th gestational weeks were determined.

Photonic Crystal-Embedded Molecularly Imprinted Contact Lenses for Controlled Drug Release.

As a noninvasive eye disease detection and drug delivery device, contact lenses can improve eye bioavailability and enable continuous drug delivery. In order to monitor the release of drugs in real time, molecularly imprinted contact lenses (MICLs) based on photonic crystals (PCs) were prepared for the treatment of diabetes-related diseases. The specific adsorption of molecularly imprinted polymers on dexamethasone sodium phosphate (DSP) increased the drug loading and optimized the drug release behavior.

miR-20a/Foxj2 Axis Mediates Growth and Metastasis of Colorectal Cancer Cells as Identified by Integrated Analysis.

BACKGROUND MicroRNAs (miRNAs) have a significant regulatory effect on the proliferation, migration, and invasion of cells, and have been widely reported to have oncogenic or tumor-suppressive impacts on various tumors. In the present study we assessed the regulation and function of miR-20a on colorectal cancer (CRC) cell lines. MATERIAL AND METHODS qPCR was used to quantify miR-20a expression.

RNA-sequencing analysis reveals the potential contribution of lncRNAs in palmitic acid-induced insulin resistance of skeletal muscle cells.

Insulin resistance (IR) has been considered as the common pathological basis and developmental driving force for most metabolic diseases. Long noncoding RNAs (lncRNAs) have emerged as pivotal regulators in modulation of glucose and lipid metabolism. However, the comprehensive profile of lncRNAs in skeletal muscle cells under the insulin resistant status and the possible biological effects of them were not fully studied.