Publications by authors named "Lanlan Ling"
Introduction: Bruton's tyrosine kinase (BTK) inhibitors have long been known in the treatment of B-cell malignancies. Recently, BTK inhibitors have also become promising novel treatment reagents for prostate cancer. The current study was designed to investigate expression of BTK in prostate cancer tissues in comparison with benign hyperplasia and effect of BTK inhibitor on prostate cancer cell proliferation, migration and invasion.
View Article and Find Full Text PDF[Therapeutic Response and Prognosis of Adult Acute Myeloid Leukemia with Chromosome Karyotype Abnormalities].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2019
Article Synopsis
- The study aimed to analyze the effectiveness and prognosis of acute myeloid leukemia (AML) patients based on chromosome karyotype abnormalities by investigating clinical features and treatment responses in 91 patients.
- Results showed that while there was no significant difference in complete remission and overall response rates between patients with normal and abnormal karyotypes, those with abnormal karyotypes experienced higher recurrence rates and longer relapse-free survival for normal karyotype patients.
- The conclusion drawn indicates that having an abnormal karyotype is an independent prognostic factor in AML, with a particular mention that monosomal karyotypes are associated with poorer outcomes and higher recurrence rates.
The FMS-like tyrosine kinase 3-internal tandem duplication () gene mutation is present in ~20% of patients with acute myeloid leukemia (AML). Patients with an mutation have a poor prognosis. However, the prognostic function of combined with other cytogenetic abnormalities are not clear.
View Article and Find Full Text PDFThe specific prognostic factors and the long-term effects of different treatment options in APL remain unclear. In this retrospective study, 70 APL patients were treated with ATRA + DNR/DA or ATRA + ATO regimens for induction therapy and DA or ATRA + ATO for consolidation and maintenance therapy. The prognostic factors and treatment effects on outcome were analyzed.
View Article and Find Full Text PDF[Differential Regulation of Bruton's Tyrosine Kinase by the Ubiquitin Pathway].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2017
Article Synopsis
- The study aimed to understand how Bruton's tyrosine kinase (Btk) is regulated and its underlying mechanisms.
- Researchers used various treatments to assess the mRNA and protein levels of Btk and found that its expression is influenced by factors like proteasome inhibitors and phorbol esters (PMA).
- The results indicate that Btk is regulated through ubiquitination, particularly by the E3 ligase Cbl, impacting its stability and activation in cells.