Polyarylmethylpiperidinium (PAMP) for Next Generation Anion Exchange Membranes.

Terawatt-scale hydrogen production using anion exchange membrane water electrolyzers (AEM-WEs) requires the development of facilely prepared, alkali-stable, and high-performance anion exchange membranes (AEMs). State-of-the-art polyarylpiperidinium AEMs fail to match the alkaline stability of piperidinium due to conformational deformation caused by the stiff cardo structure. Herein, polyarylmethylpiperidinium (PAMP) AEM with pendant structure is constructed by utilizing 4-formylpiperidine as a functional monomer.

Shenling Baizhu Decoction treats ulcerative colitis of spleen-deficiency and dampness obstruction types by targeting 'gut microbiota and galactose metabolism-bone marrow' axis.

Ethnopharmacological Relevance: Shenlin Baizhu Decoction (SLBZD), which comes from 'Taiping Huimin Heji Ju Fang', belongs to a classical prescription for treating spleen deficiency and dampness obstruction (SQDDS)-type ulcerative colitis (UC) in traditional Chinese medicine. However, the mechanism of SLBZD in treating UC with SQDDS remains unclear.

Aim Of The Study: This study aims to investigate the mechanism of SLBZD against SQDDS-type UC of based on the "gut microbiota and metabolism - bone marrow" axis to induce endogenous bone marrow mesenchymal stem cells (BMSCs) homing.

Closing Kok's cycle of nature's water oxidation catalysis.

The MnCaO cluster in photosystem II catalyzes water splitting through the S state cycle (i = 0-4). Molecular O is formed and the natural catalyst is reset during the final S → (S) → S transition. Only recently experimental breakthroughs have emerged for this transition but without explicit information on the S-state reconstitution, thus the progression after O release remains elusive.

Poly(Dibenzothiophene-Terphenyl Piperidinium) for High-Performance Anion Exchange Membrane Water Electrolysis.

The anion exchange membrane water electrolysis is widely regarded as the next-generation technology for producing green hydrogen. The OH conductivity of the anion exchange membrane plays a key role in the practical implementation of this device. Here, we present a series of Z-S-x membranes with dibenzothiophene groups.

Stable Anion Exchange Membrane Bearing Quinuclidinium for High-performance Water Electrolysis.

Anion exchange membranes (AEMs) are core components in anion exchange membrane water electrolyzers (AEM-WEs). However, the stability of functional quaternary ammonium cations, especially under high temperatures and harsh alkaline conditions, seriously affects their performance and durability. Herein, we synthesized a 1-methyl-3,3-diphenylquinuclidinium molecular building unit.

The mechanism of gut-lung axis in pulmonary fibrosis.

Pulmonary fibrosis (PF) is a terminal change of a lung disease that is marked by damage to alveolar epithelial cells, abnormal proliferative transformation of fibroblasts, excessive deposition of extracellular matrix (ECM), and concomitant inflammatory damage. Its characteristics include short median survival, high mortality rate, and limited treatment effectiveness. More in-depth studies on the mechanisms of PF are needed to provide better treatment options.

The characteristics of trimethylamine N-oxide content in different classes of marine animals over the coastal and offshore areas of China.

Trimethylamine N-oxide (TMAO) is widely present in marine animals. However, the characteristics of TMAO content in different classes of marine animals are insufficiently understood. In this study, the TMAO content in 79 marine animals (48 species, 7 classes) collected in the coastal and offshore areas of China during year 2019-2022 was analysed.

Complexation of a Nitrilotriacetate-Derived Triamide Ligand with Trivalent Lanthanides: A Thermodynamic and Crystallographic Study.

Non-heterocyclic N-donor nitrilotriacetate-derived triamide ligands are one of the most promising extractants for the selective extraction separation of trivalent actinides over lanthanides, but the thermodynamics and mechanism of the complexation of this kind of ligand with actinides and lanthanides are still not clear. In this work, the complexation behaviors of ,,',',″,″-hexaethylnitrilotriacetamide (NTAamide(Et)) with four representative trivalent lanthanides (La, Nd, Eu, and Lu) were systematically investigated by using H nuclear magnetic resonance (H NMR), ultraviolet-visible (UV-vis) and fluorescence spectrophotometry, microcalorimetry, and single-crystal X-ray diffractometry. H NMR spectroscopic titration of La and Lu indicates that two species of 1:2 and 1:1 metal-ligand complexes were formed in NO and ClO media.

Electron-hopping across dye-sensitized mesoporous NiO surfaces.

To gain a deeper understanding of the underlying charge processes in dye sensitized photocathodes, lateral electron hopping across dye-sensitized NiO photocathodes was investigated. For dye-sensitized systems, hole hopping across photoanodes has been studied extensively in the literature but no expansive studies on electron hopping in sensitized photocathodes exist today. Therefore, an organic p-type dye (TIP) with donor-linker-acceptor design, showing high stability and electrochemical reversibility, was used to study the electron transfer dynamics (electron-hopping) between dyes with temperature dependent spectroelectrochemistry and computational simulations.

[Pathogen Distribution,Imaging Characteristics,and Establishment and Verification of Risk Prediction Model of Pulmonary Infection with Multi-drug Resistant Organism in Patients with Severe Craniocerebral Injury].

Objective To investigate the pathogen distribution,imaging characteristics,and risk factors of pulmonary infection with multi-drug resistant organism (MDRO) in patients with severe craniocerebral injury,and establish and verify the risk prediction model. Methods A total of 230 patients with severe craniocerebral injury complicated with pulmonary infection were collected retrospectively.According to the 7∶3 ratio,they were randomly assigned into a modeling group (161 patients) and a validation group (69 patients).

Extraction and Complexation Investigation of Palladium(II) by a Nitrilotriacetate-Derived Triamide Ligand.

Effective and selective separation and recovery of the fission product palladium from high-level liquid waste are conducive not only to reducing its hazards to the public health and environment but also to alleviate the pressure on the increasing demand for natural palladium. Herein, the Pd extraction in an HNO solution with a nitrilotriacetate-derived triamide ligand NTAamide(-Oct) and the complexation between them were investigated. Using -octanol as a diluent, NTAamide(-Oct) demonstrated an excellent selectivity, strong extractability, and high loading capacity for Pd extraction.

Pyrene-Based Dopant-Free Hole-Transport Polymers with Fluorine-Induced Favorable Molecular Stacking Enable Efficient Perovskite Solar Cells.

A new class of polymeric hole-transport materials (HTMs) are explored by inserting a two-dimensionally conjugated fluoro-substituted pyrene into thiophene and selenophene polymeric chains. The broad conjugated plane of pyrene and "Lewis soft" selenium atoms not only enhance the π-π stacking of HTM molecules greatly but also render a strong interaction with the perovskite surface, leading to an efficient charge transport/transfer in both the HTM layer and the perovskite/HTM interface. Note that fluorine substitution adjacent to pyrene boosts the stacking of HTMs towards a more favorable face-on orientation, further facilitating the efficient charge transport.

The Effects of Rso2 and PI Monitoring Images on the Treatment of Premature Infants Based on Deep Learning.

In recent years, due to the combined effects of individual behavior, psychological factors, environmental exposure, medical conditions, biological factors, etc., the incidence of preterm birth has gradually increased, so the incidence of various complications of preterm infants has also become higher and higher. This article is aimed at studying the therapeutic effects of preterm infants and proposing the application of rSO2 and PI image monitoring based on deep learning to the treatment of preterm infants.

A Phenanthrocarbazole-Based Dopant-Free Hole-Transport Polymer with Noncovalent Conformational Locking for Efficient Perovskite Solar Cells.

Adequate hole mobility is the prerequisite for dopant-free polymeric hole-transport materials (HTMs). Constraining the configurational variation of polymer chains to afford a rigid and planar backbone can reduce unfavorable reorganization energy and improve hole mobility. Herein, a noncovalent conformational locking via S-O secondary interaction is exploited in a phenanthrocarbazole (PC) based polymeric HTM, PC6, to fix the molecular geometry and significantly reduce reorganization energy.

The dynamics of light-induced interfacial charge transfer of different dyes in dye-sensitized solar cells studied by molecular dynamics.

The charge-transport dynamics at the dye-TiO interface plays a vital role for the resulting power conversion efficiency (PCE) of dye sensitized solar cells (DSSCs). In this work, we have investigated the charge-exchange dynamics for a series of organic dyes, of different complexity, and a small model of the semiconductor substrate TiO. The dyes studied involve L1, D35 and LEG4, all well-known organic dyes commonly used in DSSCs.

Identification of lnc RNAs Related to Prognosis of Patients With Colorectal Cancer.

The purpose of this study was to identify long noncoding RNAs (lncRNAs) related to prognosis of patients with colorectal cancer (CRC) and develop a prognostic prediction model for CRC. Transcriptome data and survival information of CRC patients were downloaded from The Cancer Genome Atlas. The differentially expressed lncRNAs (DElncRNAs) between CRC and normal colorectal tissues were identified by the edgeR package.

Conformational and Compositional Tuning of Phenanthrocarbazole-Based Dopant-Free Hole-Transport Polymers Boosting the Performance of Perovskite Solar Cells.

Conjugated polymers are regarded as promising candidates for dopant-free hole-transport materials (HTMs) in efficient and stable perovskite solar cells (PSCs). Thus far, the vast majority of polymeric HTMs feature structurally complicated benzo[1,2-:4,5-']dithiophene (BDT) analogs and electron-withdrawing heterocycles, forming a strong donor-acceptor (D-A) structure. Herein, a new class of phenanthrocarbazole ()-based polymeric HTMs (, , and ) has been synthesized by inserting a unit into a polymeric thiophene or selenophene chain with the aim of enhancing the π-π stacking of adjacent polymer chains and also to efficiently interact with the perovskite surface through the broad and planar conjugated backbone of the .

Efficient Naphthalene Imide-Based Interface Engineering Materials for Enhancing Perovskite Photovoltaic Performance and Stability.

The ways to overcome surface charge recombination and poor interface contact are still the central challenges for the development of inorganic-organic hybrid halide perovskite solar cells (PSCs). [6,6]-Phenyl C butyric acid methyl ester (PCBM) is commonly employed in PSCs, but it has some disadvantages including high charge recombination and poor surface coverage. Therefore, the addition of an interfacial engineering layer showing efficient surface passivation, electron extraction, and excellent interface contact can solve the above problems.

Association of sarcopenia and muscle mass with both peripheral neuropathy and nerve function in patients with type 2 diabetes.

Aim: This study aimed to investigate the association of sarcopenia and muscle mass with both peripheral neuropathy and nerve function in type 2 diabetes mellitus.

Methods: A total of 1794 patients (937 men and 857 women) with type 2 diabetes, with a mean age of 60.22 years, were enrolled for a cross-sectional study; of these, 183 patients were enrolled for a follow-up study with a median follow-up of 2.

Theoretical reflections on the structural polymorphism of the oxygen-evolving complex in the S state and the correlations to substrate water exchange and water oxidation mechanism in photosynthesis.

The structural polymorphism of the oxygen-evolving complex is of great significance to photosynthetic water oxidation. Employing density functional theory calculations, we have made further advisement on the interconversion mechanism of O5 transfer in the S state, mainly focusing on the potentiality of multi-state reactivity and spin transitions. Then, O5 protonation is proven impossible in S for irreversibility of the interconversion, which serves as an auxiliary judgment for the protonation state of O5 in S.

The open-cubane oxo-oxyl coupling mechanism dominates photosynthetic oxygen evolution: a comprehensive DFT investigation on O-O bond formation in the S state.

The dioxygen formation mechanism of biological water oxidation in nature has long been the focus of argument; many diverse mechanistic hypotheses have been proposed. Based on a recent breakthrough in the resolution of the electronic and structural properties of the oxygen-evolving complex in the S state, our density functional theory (DFT) calculations reveal that the open-cubane oxo-oxyl coupling mechanism, whose substrates preferably originate from W2 and O5 in the S state, emerges as the best candidate for O-O bond formation in the S state. This is justified by the overwhelming energetic superiority of this mechanism over alternative mechanisms in both the isomeric open and closed-cubane forms of the MnCaO cluster; spin-dependent reactivity rooted in variable magnetic couplings was found to play an essential role.

How does ammonia bind to the oxygen-evolving complex in the S state of photosynthetic water oxidation? Theoretical support and implications for the W1 substitution mechanism.

Ammonia as a water analogue can bind to the MnCaO cluster of the oxygen-evolving complex in concomitance with ligand substitution and underlying structural transformation. On account of current controversies of the binding site and the absence of the viewpoint of reactivity and mechanistic proofs, we have investigated three modes of NH binding based on our elaborations of the possible reaction mechanisms, in correspondence with experimental observation for the NH-altered g ≈ 2.0 EPR multiline signal.

Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis.

Purpose: Several molecular epidemiological studies have investigated the association between OPN rs11730582 C>T polymorphism and cancer risk, but the results are inconsistent. Hence, a meta-analysis was conducted to determine the association of this polymorphism with cancer risk.

Materials And Methods: The related articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases.