Publications by authors named "Langzi Tan"
Article Synopsis
- Researchers conducted a study comparing verbal fluency in patients with temporal lobe epilepsy (TLE), specifically those with (TLE-HS) and without hippocampal sclerosis (TLE-NHS), alongside healthy controls.
- The study utilized a Chinese character verbal fluency task during functional MRI, revealing that TLE-HS showed deficits in brain activation and functional connectivity, while TLE-NHS demonstrated enhanced connectivity, indicating different compensatory strategies.
- A neural network model was effective in classifying TLE-HS versus TLE-NHS, achieving high accuracy, and suggesting that the phonemic verbal fluency task is valuable for clinical assessment in TLE patients.
Article Synopsis
- The study investigates how cerebellar function is affected in patients with mesial temporal lobe epilepsy (MTLE), which can lead to cognitive decline.
- Researchers analyzed data from 60 participants, including patients with left and right temporal lobe epilepsy (TLE) and healthy controls, using functional MRI during a verbal fluency task.
- Results revealed significant differences in cerebellar connectivity and centrality between the patient groups, indicating that these functional changes were linked to poorer cognitive performance in memory tests.*
Aim: Temporal lobe epilepsy is a neurological network disease in which genetics played a greater role than previously appreciated. This study aimed to explore shared functional network abnormalities in patients with sporadic temporal lobe epilepsy and their unaffected siblings.
Methods: Fifty-eight patients with sporadic temporal lobe epilepsy, 13 unaffected siblings, and 30 healthy controls participated in this cross-sectional study.
Objective: This work was undertaken to study the functional connectivity differences between non-seizure-free and seizure-free patients with temporal lobe epilepsy (TLE) and to identify imaging predictors for drug responsiveness in TLE.
Methods: In this prospective study, 52 patients with TLE who presented undetermined antiseizure medication responsiveness and 55 demographically matched healthy controls were sequentially recruited from Xiangya Hospital. Functional magnetic resonance imaging data were acquired during a Chinese version of the verbal fluency task.
Feature of cognitive dysfunction in patients with temporal lobe epilepsy and its clinical influencing factors.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
March 2021
Objectives: To comprehensively analyze the characteristics of cognitive impairment of temporal lobe epilepsy (TLE), and to explore the effects of different lateral patients' cognitive impairment and different clinical factors on cognitive impairment of TLE.
Methods: A total of 84 patients, who met the diagnostic criteria for TLE in the Department of Neurology, Xiangya Hospital, were collected as a patient group, with 36 cases of left TLE and 48 cases of right TLE. A total of 79 healthy volunteers with matching gender, age and education level were selected as a control group.
The present study was performed to investigate the clinical manifestations and pathogenic variants in three large families with autosomal dominant paroxysmal kinesigenic dyskinesia (PKD) and/or benign familial infantile epilepsy (BFIE) in China. Detailed clinical data and family history were collected. Genomic DNA was isolated from the peripheral blood samples of all available members.
View Article and Find Full Text PDFImpaired Cognitive Abilities in Siblings of Patients with Temporal Lobe Epilepsy.
Neuropsychiatr Dis Treat
December 2020
Purpose: Patients with temporal lobe epilepsy (TLE) are at high risk of cognitive impairment. In addition to persistent seizures and antiepileptic drugs (AEDs), genetic factors also play an important role in the progression of cognitive deficits in TLE patients. Defining a cognitive endophenotype for TLE can provide information on the risk of cognitive impairment in patients.
View Article and Find Full Text PDFCognitive impairment in children with benign childhood epilepsy with centrotemporal spikes (BECT) has complex etiologies and is closely associated abnormal neural networks. Multimodal magnetic resonance imaging of brain structure and function is a powerful tool for studying abnormal neural networks of cognitive impairment in epilepsy and can explore the pathogenesis of cognitive impairment in epilepsy at the level of brain structure and function by analyzing the imaging features of brain structure and function. This article reviews the research advances in multimodal magnetic resonance for cognitive impairment in children with BECT.
View Article and Find Full Text PDFObjective: Identifying the factors that are correlated with and predictive of reduced quality of life (QOL) is essential to optimize the treatment of epilepsy and the management of comorbidities.
Methods: We analyzed the independent associations between the Quality of Life in Epilepsy-31 (QOLIE-31) inventory and the demographic, clinical, psychiatric, and cognitive variables of 47 consecutive patients with temporal lobe epilepsy (TLE). Predictors of the correlated variables were analyzed by multiple linear regression analysis.