Efficacy of Auricular Therapy for Motor Impairment After Stroke: A Systematic Review and Meta-Analysis.

Background: A high number of stroke patients cannot recover fully from motor impairment despite early rehabilitation. Auricular therapies, usually given by acupuncture doctors or nurses, have been widely used among these post-stroke patients. Potential benefits of auricular therapies were shown in recent clinical trials.

Molecular Ferroelectrics for Highly Sensitive Detection Toward Low-Frequency Sound Recognition.

Human hearing cannot sensitively detect sounds below 100 Hz, which can affect the physical well-being and lead to dizziness, headaches, and nausea. Piezoelectric acoustic sensors still lack sensitivity to low-frequency sounds owing to the low piezoelectric coefficient or high elastic modulus of materials. The low elastic modulus and substantial piezoelectric coefficient of molecular ferroelectric materials make them excellent candidates for acoustic sensors.

[Acupuncture based on "status-target coherence" theory combined with Kegel exercises for vaginal laxity syndrome: a randomized controlled trial].

Objective: To observe the clinical efficacy of acupuncture based on "status-target coherence" theory combined with Kegel exercises for vaginal laxity syndrome (VLS).

Methods: Sixty-six patients with VLS were randomized into an observation group (33 cases, 2 cases dropped out, 1 case was discontinued) and a control group (33 cases, 5 cases dropped out). The observation group was treated with acupuncture combined with Kegel exercises, acupuncture was applied to bilateral Ciliao (BL32), Zhongliao (BL33), Sanyinjiao (SP6), etc.

Tuning Nitrogen Configurations in Nitrogen-Doped Graphene Encapsulating FeC Nanoparticles for Enhanced Nitrate Electroreduction.

Electrochemical nitrate reduction reaction (NORR) offers a promising technology for the synthesis of ammonia (NH) and removal of nitrate in wastewater. Herin, we fabricate a series of FeC nanoparticles in controllable pyridinic-N doped graphene (FeC@NG-X) by a self-sacrificing template method for the NORR. FeC@NG-10 exhibits high catalytic performance with a Faradaic efficiency (FE) of 94.

Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia-reperfusion injury via Wnt/β-catenin pathway modulation.

Anchusa italica Retz. (AIR), a traditional herbal remedy, is commonly applied in managing heart and brain disorders. However, its specific function and mechanism in acute cerebral ischemia-reperfusion injury (CIRI) are not fully understood.

CRISPR/Cas13X-assisted programmable and multiplexed translation regulation for controlled biosynthesis.

Developing efficient gene regulation tools is essential for optimizing microbial cell factories, but most existing tools only modulate gene expression at the transcriptional level. Regulation at the translational level provides a faster dynamic response, whereas developing a programmable, efficient and multiplexed translational regulation tool remains a challenge. Here, we have developed CRISPRi and CRISPRa systems based on hfCas13X that can regulate gene translation in Bacillus subtilis.

A novel potential measurement indicator with objective and quantitative effect for trigeminal neuralgia: fractional anisotropy in MR-DTI.

Objectives: To investigate the effect of diffusivity metrics of magnetic resonance diffusion tensor imaging (MR-DTI) in the assessment of treatment effects.

Methods: MR-DTI examination for trigeminal neuralgia (TN) patients and the diffusivity metrics of the trigeminal ganglion (TG) were analyzed. Before and after the percutaneous stereotactic radiofrequency rhizotomy (PSR) operation, the treatment effect was assessed using pain scores and MR-DTI.

Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava: A retrospective cohort study.

Background: Laparoscopic liver resection (LLR) can be challenging due to the difficulty of establishing a retrohepatic tunnel under laparoscopy. Dissecting the third hepatic hilum before parenchymal transection often leads to significant liver mobilization, tumor compression, and bleeding from the short hepatic veins (SHVs). This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava (IVC), allowing SHVs to be addressed after parenchymal transection, thereby reducing surgical complexity and improving outcomes in in situ LLR.

Perceived discrimination as a predictor of cyberbullying: the mediating role of self-esteem and moderating role of self-compassion.

With the popularity of the internet, cyberbullying has emerged as an increasingly serious social issue, particularly affecting college students' behavioral health. This study explores the relationship between perceived discrimination and cyberbullying, as well as the mediating role of self-esteem and the moderating role of self-compassion (SC) in this relationship. Using a longitudinal design, data were collected from 892 Chinese college students (414 females, 478 males) in two waves spanning 1 year.

PGM3 insufficiency: a glycosylation disorder causing a notable T cell defect.

Background: Hypomorphic mutations in the () gene cause a glycosylation disorder that leads to immunodeficiency. It is often associated with recurrent infections and atopy. The exact etiology of this condition remains unclear.

Recent advances in the role of atypical cadherin FAT1 in tumorigenesis (Review).

The FAT atypical cadherin 1 (FAT1) gene is the ortholog of the fat gene and encodes the protocadherin FAT1. FAT1 belongs to the cadherin superfamily, a group of full-length membrane proteins that contain cadherin-like repeats. In various types of human cancer, FAT1 is one of the most commonly mutated genes, and is considered to be an emerging cancer biomarker and a potential target for novel therapies.

Deer antler reserve mesenchyme cells modified with miR-145 promote chondrogenesis in cartilage regeneration.

Deer antler-derived reserve mesenchyme cells (RMCs) are a promising source of cells for cartilage regeneration therapy due to their chondrogenic differentiation potential. However, the regulatory mechanism has not yet been elucidated. In this study, we analyzed the role of microRNAs (miRNAs) in regulating the differentiation of RMCs and in the post-transcriptional regulation of chondrogenesis and hypertrophic differentiation at the molecular and histological levels.

Drug-phospholipid conjugate nano-assembly for drug delivery.

Phospholipid-based liposomes are among the most successful nanodrug delivery systems in clinical use. However, these conventional liposomes present significant challenges including low drug-loading capacity and issues with drug leakage. Drug-phospholipid conjugates (DPCs) and their assemblies offer a promising strategy for addressing these limitations.

Change in p53 nuclear localization in response to extracellular matrix stiffness.

Chondrocytes are commonly applied in regenerative medicine and tissue engineering. Thus, the discovery of optimal culture conditions to obtain cells with good properties and behavior for transplantation is important. In addition to biochemical cues, physical and biomechanical changes can affect the proliferation and protein expression of chondrocytes.

Mechanistic analysis of Tanshinone IIA's regulation of the ATM/GADD45/ORC signaling pathway to reduce myocardial ischemia-reperfusion injury.

Background: By far, one of the best treatments for myocardial ischemia is reperfusion therapy. The primary liposoluble component of Danshen, a traditional Chinese herbal remedy, Tanshinone ⅡA, has been shown to have cardiac healing properties. The purpose of this work is to investigate the processes by which Tanshinone ⅡA influences myocardial ischemia-reperfusion injury (MIRI) in the H9C2 cardiac myoblast cell line, as well as the association between Tanshinone ⅡA and MIRI.

Fumarprotocetraric acid and geraniin were identified as novel inhibitors of human respiratory syncytial virus infection .

Introduction: Respiratory syncytial virus (RSV) remains a major international public health concern. However, disease treatment is limited to preventive care with monoclonal antibodies and supportive care. In this study, natural products were screened to identify novel anti-RSV inhibitors.

Masking Ability of Subtractively and Additively Manufactured Dental Ceramic Restorations: A Systematic Review.

Objective: To conduct a systematic review on the masking ability of subtractively and additively manufactured dental ceramics.

Materials And Methods: The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The electronic search was carried out through MEDLINE, Scopus, and Website of Science databases with a date restriction being from 2001 onwards.

Structural analysis of a membrane-associated delta-6 fatty acid desaturase from Prorocentrum micans.

Delta-6 fatty acid desaturases, which play key roles in the biosynthesis of polyunsaturated fatty acids (PUFAs), are membrane-associated enzymes that present significant challenges for isolation and purification, complicating their structural characterization. Here we report the identification and structure-function analysis of a novel Δ6 fatty acid desaturase (PmD6) from the marine alga Prorocentrum micans with substrate preference to α-linolenic acid (18:3n-3). Structural modeling revealed a mushroom-like structure of PmD6 formed by four transmembrane α-helices as a stem and three cytoplasmic domains as a cap.

Ferroelectric Optical Memristors Enabled by Non-Volatile Electro-Optic Effect.

Memristors enable non-volatile memory and neuromorphic computing. Optical memristors are the fundamental element for programmable photonic integrated circuits due to their high-bandwidth computing, low crosstalk, and minimal power consumption. Here, an optical memristor enabled by a non-volatile electro-optic (EO) effect, where refractive index modulation under zero field is realized by deliberate control of domain alignment in the ferroelectric material Pb(MgNb)O-PbTiO(PMN-PT) is proposed.

Programmable Electromagnetic Wave Absorption via Tailored Metal Single Atom-Support Interactions.

Metal single atoms (SA)-support interactions inherently exhibit significant electrochemical activity, demonstrating potential in energy catalysis. However, leveraging these interactions to modulate electronic properties and extend application fields is a formidable challenge, demanding in-depth understanding and quantitative control of atomic-scale interactions. Herein, in situ, off-axis electron holography technique is utilized to directly visualize the interactions between SAs and the graphene surface.

SH2D5 promotes lung adenocarcinoma cell metastasis and triggers EMT via activating AKT signaling pathway.

Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer, characterized by a high incidence in late stages, high mortality rate, and poor prognosis. Src Homology 2 Domain Containing Protein 5 (SH2D5) is a mammalian-specific, uncharacterized scaffolding protein, and its role in LUAD remains unclear. In the present study, we investigated the function and potential mechanisms of SH2D5 in the progression of LUAD.

Reactive and Proactive Aggression in Daily Life: An Exploratory Experience-Sampling Method Study.

Trait aggression is often separated into two functional dimensions: reactive and proactive tendencies. Reactive aggression is the tendency to engage in emotionally driven aggressive responses to perceived provocation, whereas proactive aggression is the tendency to engage in premeditated aggressive behaviors in the service of goal attainment. To date, the majority of empirical investigations examining these interrelated constructs have done so using cross-sectional data that have important limitations (e.

NRGCNMDA: Microbe-Drug Association Prediction Based on Residual Graph Convolutional Networks and Conditional Random Fields.

The process of discovering new drugs related to microbes through traditional biological methods is lengthy and costly. In response to these issues, a new computational model (NRGCNMDA) is proposed to predict microbe-drug associations. First, Node2vec is used to extract potential associations between microorganisms and drugs, and a heterogeneous network of microbes and drugs is constructed.

Droplet microfluidics: unveiling the hidden complexity of the human microbiome.

The human body harbors diverse microbial communities essential for maintaining health and influencing disease processes. Droplet microfluidics, a precise and high-throughput platform for manipulating microscale droplets, has become vital in advancing microbiome research. This review introduces the foundational principles of droplet microfluidics, its operational capabilities, and wide-ranging applications.