Image-localized biopsy mapping of brain tumor heterogeneity: A single-center study protocol.

Brain cancers pose a novel set of difficulties due to the limited accessibility of human brain tumor tissue. For this reason, clinical decision-making relies heavily on MR imaging interpretation, yet the mapping between MRI features and underlying biology remains ambiguous. Standard (clinical) tissue sampling fails to capture the full heterogeneity of the disease.

A method for the development of cranial fracture histology slides.

Cranial vault fractures are of medicolegal interest as they have long-term impacts to someone's health and may contribute to an individual's death. The ability to distinguish antemortem from perimortem fractures and to assess the age of the injury is increasingly dependent on histology. Despite the increasing role of histology in assessing the microanatomy of osseous fractures, there are no methods currently available which account for the nuances and difficulties in creating high-quality histologic slides of cranial vault fractures that allow visualization of cellular features associated with healing bone.

Nationwide estimate of emergency department visits in the United States related to caustic ingestion.

Introduction: Caustic ingestion, whether intentional or unintentional, may result in significant morbidity. Our aim was to provide an estimate of the incidence and outcomes of caustic ingestion among emergency department (ED) visits across the United States.

Methods: The Nationwide Emergency Department Sample (NEDS) is part of the family of databases developed for the Healthcare Cost and Utilization Project.

Emerging strategies for the treatment of gastroparesis.

Gastroparesis is a syndrome of delayed gastric emptying in the absence of mechanical obstruction. Symptoms can be debilitating, affect nutritional states, and significantly impact patients' quality of life. The management of these patients can prove quite difficult to many providers.

Mutation of essential Hsp90 co-chaperones SGT1 or CNS1 renders yeast hypersensitive to overexpression of other co-chaperones.

The essential molecular chaperone Hsp90 functions with over ten co-chaperones in Saccharomyces cerevisiae, but the in vivo roles of many of these co-chaperones are poorly understood. Two of these co-chaperones, Cdc37 and Sgt1, target specific types of clients to Hsp90 for folding. Other co-chaperones have general roles in supporting Hsp90 function, but the degree of overlapping or competing functions is unclear.

A survey of accessibility and utilisation of chiropractic services for wheelchair-users in the United Kingdom: What are the issues?

Background: People with physical disabilities experience barriers to healthcare across all services despite a legal and moral obligation to the contrary. Complementary medicine is considered as supplementary to conventional care and integration of these approaches is essential to achieve optimal care. This paper explores the utilisation of chiropractic services and practitioner experiences of treating wheelchair-users which appears under-reported.

Back pain outcomes in primary care following a practice improvement intervention:- a prospective cohort study.

Background: Back pain is one of the UK's costliest and least understood health problems, whose prevalence still seems to be increasing. Educational interventions for general practitioners on back pain appear to have had little impact on practice, but these did not include quality improvement learning, involve patients in the learning, record costs or document practice activities as well as patient outcomes.

Methods: We assessed the outcome of providing information about quality improvement techniques and evidence-based practice for back pain using the Clinical Value Compass.

Withdrawal rates as a consequence of disclosure of risk associated with manipulation of the cervical spine.

Background: The risk associated with cervical manipulation is controversial. Research in this area is widely variable but as yet the risk is not easily quantifiable. This presents a problem when informing the patient of risks when seeking consent and information may be withheld due to the fear of patient withdrawal from care.

Consent: its practices and implications in United kingdom and United States chiropractic practice.

Objective: This study explores the implementation of consent procedures in a sample of chiropractors in the United Kingdom (UK) and the United States (US) and how well they satisfy the core ethical principles of autonomy, veracity, justice, nonmaleficence, and beneficence.

Methods: A precoded questionnaire was sent to 500 geographically stratified, randomly selected chiropractors in the UK and 500 similarly selected chiropractors within 10 states (50 from each) across the US. Questionnaires were dispatched 100 per month over a 5-month period.

Psychosocial factors and their predictive value in chiropractic patients with low back pain: a prospective inception cohort study.

Background: Being able to estimate the likelihood of poor recovery from episodes of back pain is important for care. Studies of psychosocial factors in inception cohorts in general practice and occupational populations have begun to make inroads to these problems. However, no studies have yet investigated this in chiropractic patients.

Consent or submission? The practice of consent within UK chiropractic.

Background: A patient's right to accept or reject proposed treatment is both an ethical and legal tenet. Valid consent is a multifaceted, controversial and often complicated process, yet practitioners are obligated to try to obtain consent from their patients. Its omission is a common basis for malpractice suits and increasing utilization of complementary and alternative services in conventional medical settings is intensifying the focus on medical liability issues.

Third Prize: Chiropractic and the national health care system: a basis for partnership in the UK.

Background: Changes in United Kingdom (UK) health care policy and legislation have the potential to radically change care for patients with musculoskeletal conditions by widening access to manipulation services under its National Health Service (NHS).

Objective: To investigate chiropractors past and current provision of musculoskeletal services for NHS patients and optimal future arrangements.

Methods: One thousand forty-two UK chiropractors on professional registers were sent a 2-part questionnaire.

General practice and chiropractic in Norway: how well do they communicate and what do GPs want to know?

Background: Some within the medical establishment believe that the education and training of chiropractors is grounded in orthodox medicine and that these professional groups share a common language allowing for close dialogue. However, levels of communication and collaboration often remain low. Furthermore, studies have shown chiropractors to be lax in providing written reports to referring clinicians, a practice important to both patient care and interprofessional relationships.

Coherent bremsstrahlung from relativistic electrons in quasicrystals.

In this paper we develop a Born-approximation theory of coherent bremsstrahlung (CB) production by relativistic electrons in icosahedral quasicrystals (IQCs), described by a schematic model that incorporates the presence of phonon and phason disorder. Our main result is a formula for the cross section d sigma(CB)/dk of this process, differential with respect to the photon energy k. It predicts intense low-energy CB emission (type-A CB) when an electron is incident on an IQC along a direction almost, but not exactly, parallel to that of a major axis.

Chiropractic through the eyes of physiotherapists, manual therapists, and osteopaths in The Netherlands.

Objectives: To identify current perceptions and levels of awareness of chiropractic among physiotherapists, osteopaths, and manual therapists in The Netherlands. In addition, to investigate how future communication and interprofessional collaboration between the four professions may be improved in the interests of patient care as perceived by these groups.

Design: Four hundred and ninety-four (494) questionnaires were distributed to 100 manual therapists, 299 physiotherapists, and 95 osteopaths across The Netherlands.

Rationalizing back pain: the development of a classification system through cluster analysis.

Objective: The clinical variations in undifferentiated back pain pose problems for those attempting to develop strategies for care. The objective of this work was to test a methodology for the experimental generation of clinical subgroups of patients with such a complaint, so as to assist more structured study of its natural history and response to treatment.

Design: Cluster analysis of dichotomous symptomatic variables from computer-based case histories of three patient cohorts.

Evaluation of impairment related to low back pain.

Low back pain is the leading cause of disability and expense from work-related conditions in the United States. Forty percent of the expense of the worker's compensation program is spent on claims involving the low back. There are several systems of impairment evaluation in use in the United States, but the most commonly used has been developed by the American Medical Association.

A general approach to chord length distributions applied to a hemisphere.

General formulas for chord and related joint density distributions of convex volumes are derived and applied to the hemisphere. The resulting single integral for the joint chord length and beam angle distribution is evaluated analytically. The chord length distribution is obtained by the same methods by evaluating a double integral.

Transulnar percutaneous pinning of displaced distal radial fractures: a preliminary report.

Difficulty in maintaining the reduction of displaced radial fractures has prompted the use of numerous techniques to address this problem. The purpose of this study was to determine if four or five 0.045-in Kirschner pins when placed percutaneously through the ulna into the radius could maintain the reduction of this unstable fracture configuration.