Assessment of accredited veterinary diagnostic laboratory use of breakpoints for canine and feline infections in the United States and Canada.

The objective of this study was to assess the use of breakpoints in antibiotic susceptibility testing among veterinary diagnostic laboratories in the United States and Canada. An eight-question survey was conducted via phone and email to determine how often laboratories use breakpoints consistent with published guidelines in wounds, lower urinary tract infections and upper urinary tract infections (pyelonephritis) involving , both in dogs and cats, for a total of 6 different hypothetical clinical scenarios. Nineteen veterinary diagnostic laboratories that perform antibiotic susceptibility testing on samples from dogs and cats in the United States or Canada and were accredited by the American Association of Veterinary Laboratory Diagnosticians (AAVLD) responded to the survey between January 15th and September 15th, 2022.

Unsupervised deep learning identifies semantic disentanglement in single inferotemporal face patch neurons.

In order to better understand how the brain perceives faces, it is important to know what objective drives learning in the ventral visual stream. To answer this question, we model neural responses to faces in the macaque inferotemporal (IT) cortex with a deep self-supervised generative model, β-VAE, which disentangles sensory data into interpretable latent factors, such as gender or age. Our results demonstrate a strong correspondence between the generative factors discovered by β-VAE and those coded by single IT neurons, beyond that found for the baselines, including the handcrafted state-of-the-art model of face perception, the Active Appearance Model, and deep classifiers.

Pharmacokinetics and pharmacodynamics of intravenous continuous rate infusion and repeated intramuscular administration of dexmedetomidine in standing horses.

An ideal dexmedetomidine protocol has yet to be determined for standing sedation in horses. It was hypothesized that an IV bolus followed by CRI dexmedetomidine would have a quicker increase in plasma concentrations compared with repeated IM injections. In a crossover design, eight adult, female horses were randomly placed into two groups: the CRI group (IV bolus dexmedetomidine at 0.

Mefenoxam, Itraconazole, and Terbinafine Combination Therapy for Management of Pythiosis in Dogs (Six Cases).

Pythium insidiosum is an oomycete that encysts in the skin or gastrointestinal tract, leading to pythiosis. Pythiosis is reported in tropical and subtropical climates, affecting dogs and rarely cats. Surgical resection is the treatment of choice; however, cases present late in the disease and lesions are often nonresectable.

Plasma and synovial fluid pharmacokinetics of a single intravenous dose of meropenem in adult horses.

The objective of this study was to determine the pharmacokinetics of meropenem in horses after intravenous (IV) administration. A single IV dose of meropenem was administered to six adult horses at 10 mg/kg. Plasma and synovial fluid samples were collected for 6 hr following administration.

Anticoagulant effects of inhaled unfractionated heparin in the dog as determined by partial thromboplastin time and factor Xa activity.

Objective: To evaluate the anticoagulant effects of inhaled heparin in dogs.

Design: This study was conducted in 3 phases. In phase 1, bronchoalveolar lavage fluid (BALf) was collected to generate an in vitro calibration curve to relate heparin concentration to the activated partial thromboplastin time (aPTT).

Pharmacokinetics and pharmacodynamics comparison between subcutaneous and intravenous butorphanol administration in horses.

The study objective was to compare butorphanol pharmacokinetics and physiologic effects following intravenous and subcutaneous administration in horses. Ten adult horses received 0.1 mg/kg butorphanol by either intravenous or subcutaneous injections, in a randomized crossover design.

Oral cyclosporine treatment in dogs: a review of the literature.

Cyclosporine is an immunomodulatory drug used to treat an increasing spectrum of diseases in dogs. Cyclosporine is a calcineurin inhibitor, ultimately exerting its inhibitory effects on T-lymphocytes by decreasing production of cytokines, such as interleukin-2. Although, in the United States, oral cyclosporine is approved in dogs only for treatment of atopic dermatitis, there are many other indications for its use.

Pharmacokinetic evaluation of oral dantrolene in the dog.

The pharmacokinetics of dantrolene and its active metabolite, 5-hydroxydantrolene, after a single oral dose of either 5 or 10 mg/kg of dantrolene was determined. The effects of exposure to dantrolene and 5-hydroxydantrolene on activated whole-blood gene expression of the cytokines interleukin-2 (IL-2) and interferon-γ (IFN-γ) were also investigated. When dantrolene was administered at a 5 mg/kg dose, peak plasma concentration (Cmax ) was 0.

Effects of carprofen, meloxicam and deracoxib on platelet function in dogs.

Objective: To determine effects of anti-inflammatory doses of COX-2 selective NSAIDs carprofen, meloxicam, and deracoxib on platelet function in dogs and urine 11-dehydro-thromboxane B2.

Study Design: Randomized, blocked, crossover design with a 14-day washout period.

Animals: Healthy intact female Walker Hounds aged 1-6 years and weighing 20.

Pharmacodynamic monitoring of canine T-cell cytokine responses to oral cyclosporine.

Background: Pharmacodynamic assays measure the immunosuppressive effects of cyclosporine on T-cells and offer an alternative assessment of efficacy in individual patients.

Objective: To assess the immunosuppressive effects of high and low dosage cyclosporine on canine T-cells and to develop a novel testing system for individualized dose adjustment.

Animals: Seven healthy female Walker hounds.

The acceptability of 'Trauma Risk Management' within the UK Armed Forces.

Background: Trauma-support programmes may benefit employees of organizations that routinely expose their staff to traumatic events. However, in order for such programmes to be effective, staff need to find them acceptable.

Aims: To investigate whether Trauma Risk Management (TRiM), an example of such a programme, is acceptable within a military population and whether it is viewed as complementing or replacing pre-existing personnel support systems.

A cluster randomized controlled trial to determine the efficacy of Trauma Risk Management (TRiM) in a military population.

Trauma Risk Management is a peer-support program that aims to promote help-seeking in the aftermath of traumatic events. Prior to its implementation, the British military conducted a randomized controlled trial of Trauma Risk Management against standard care in 12 warships; 6 were randomized to use Trauma Risk Management after collecting baseline measurements. Follow up after 12-18 months found no significant change in psychological health or stigma scores in either group; however, the studied vessels only encountered low numbers of critical incidents.

Stigma and mental health in the Royal Navy: a mixed methods paper.

Background: US research suggests that military personnel suffering from mental health problems are reluctant to seek help because of stigma.

Aims: First, to identify the prevalence of mental health stigma beliefs in a UK military sample. Second, to investigate whether distressed personnel report more stigma than those who are not distressed.

Pharmacokinetics of subcutaneous low molecular weight heparin (enoxaparin) in dogs.

Unfractionated heparin has been the standard heparin used in human and veterinary medicine for its anticoagulation effect; however, it has a complex pharmacodynamic profile that requires close monitoring. Low molecular weight heparins have a more predictable bioavailability, allowing standardized dosing without individual patient monitoring. This project was designed to a) evaluate the pharmacokinetics of the subcutaneous (SC) administration of the low molecular weight heparin, enoxaparin, in dogs using anti-Xa activity as a marker of plasma enoxaparin concentrations and b) to establish the dose necessary to maintain activity within an established target range.

Alcohol misuse in the Royal Navy.

Background: Evidence suggests that military personnel consume considerable amounts of alcohol which may have both medical and occupational implications.

Aim: To compare alcohol consumption and misuse within the Royal Navy (RN) to that in the civilian population.

Methods: The Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) questionnaire is a short measure of alcohol use disorders.

Trauma risk management (TRiM) in the UK Armed Forces.

Trauma Risk Management (TRiM) is a novel system of post incident management which intend to allow commanders to provide appropriate support to their subordinates in the aftermath of traumatic events. Given the current very considerable operational tempo being experienced by the majority of the UK Armed Forces, it is perhaps not surprising that TRiM has been in use in both Iraq and Afghanistan. Although TRiM originated from within the Royal Marines, it is now widely used in both the Royal Navy and Army; there are also plans to introduce it into specific components of the Royal Air Force such as for the RAF Regiment.

An evaluation of stress education in the Royal Navy.

Background: Psychoeducational programmes aim to reduce the morbidity associated with exposure to stressful events. Although they are widely used, there are conflicting views as to how or why they might be effective.

Aim: To examine exposure to 'stress' education within the Royal Navy (RN) and ascertain any links between stress education and mental health status.

Culture: what is its effect on stress in the military?

Culture provides the unwritten rules that inform and shape expected behaviors. To date, little research has been conducted into the attitudes or opinions that service personnel hold toward mental health issues. This article examines current literature and research into the recognition of mental health problems in the military and potential organizational barriers to care including stigma and the specific characteristics of a military culture such as the significant reliance on buddy support.

Peer responses to perceived stress in the Royal Navy.

Background: Various organizations, including the Armed Forces, regularly place their personnel into potentially traumatic environments. Exposure to such events can lead to the development of psychological distress and organizational inefficiencies. It follows that the Armed Forces need to consider how best to address and prevent trauma-related problems both from duty of care and organizational effectiveness viewpoints.

Semi-synthesis of polymyxin-B conjugated ovalbumin: evaluation of lipopolysaccharide binding avidity and neutralization of induced tnf-alpha synthesis.

A method is described in these investigations for the semi-synthetic production of polymyxin-B conjugated ovalbumin in the form of polymyxin-B.Sulfo-SMCC.ovalbumin (PSO).

Field trial of theophylline in cattle with respiratory tract disease.

A field trial was conducted to determine the efficacy of theophylline in relieving respiratory distress associated with bovine respiratory disease complex (shipping fever). Theophylline (as aminophylline capsules) was administered PO at a dosage of 28 mg/kg of body weight daily for 3 days to 20 calves with naturally acquired disease. Twenty similarly affected calves from the same group were given a placebo, and all calves were administered antibiotics concurrently.