Telomere shortening reduces Alzheimer's disease amyloid pathology in mice.

Alzheimer's disease is a neurodegenerative disorder of the elderly and advancing age is the major risk factor for Alzheimer's disease development. Telomere shortening represents one of the molecular causes of ageing that limits the proliferative capacity of cells, including neural stem cells. Studies on telomere lengths in patients with Alzheimer's disease have revealed contrary results and the functional role of telomere shortening on brain ageing and Alzheimer's disease is not known.

Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis.

Unlabelled: Telomere shortening and inactivation of cell cycle checkpoints characterize carcinogenesis. Whether these molecular features coincide at specific stages of human hepatocarcinogenesis is unknown. The preneoplasia-carcinoma sequence of human HCC is not well defined.

[Sonographic evaluation of changes in testicular tissue by ultrasound spectroscopy].

Experimental investigations were carried out under in vitro conditions on 25 normal human testicular specimens and on 60 pathological testicular specimens to ascertain the ultrasound attenuation using an ultrasound spectroscopic measuring technique. The ultrasound attenuation was established by calculating the ultrasound attenuation coefficient alpha. The average values of ultrasound attenuation (alpha) in normal testicular tissue were distinctly lower than in pathologically altered testicular specimens.

[The effect of dipyridamole on the results of allogenic kidney transplantation].

In a prospective randomized trial the anti-thrombotic effect of dipyridamole was studied in 64 patients after cadaveric kidney allotransplantation. The frequency of early graft function was significantly higher in the control group, whereas the incidence of arterial and venous thromboses were not different. One-year graft survival could not be improved by dipyridamole.

[Experiences with plasmapheresis in the treatment of vascular rejection following kidney transplantation].

In the first 6 weeks after kidney transplantation 15 patients suffering from vascular rejection were treated by 46 plasmapheres. In transplants with additional interstitial rejection the plasmapheresis was introduced after failure of ATG therapy. In 1 patient no histological confirmation was done.

[Experimental investigations on the effect of the transducer-specimen distance on the ultrasound attenuation of formalin-fixed testicular tissue].

Additional information on the tissue structure are possible by estimation of sound physical parameters in comparison with normal B-scan ultrasonography, especially the frequency-dependent ultrasound attenuation. The ultrasound attenuation measurements were made on histochemical normal and pathological testicular tissue with changing transducer-specimen distance. No markedly difference in damaging behaviour was found between normal and pathological testicular tissue at different distances.

[Influence of examining temperature on the ultrasound attenuation in testicular tissue].

By means of an ultrasound spectroscopic measurement technique the influence of examining temperature on the ultrasound attenuation was experimentally investigated on formalin-fixed normal and altered testicular tissue. In the examined tissue specimens a temperature-dependent change of ultrasound attenuation (alpha on 6 MHz) was found in the temperature area between 10 and 50 degrees C. In the altered testicular tissue a higher damping decline could be observed.

[Effect of various fixation agents on ultrasound damping in normal and pathological testicular tissues].

In normal and pathological testicular tissue the influence of various fixing agents (Formalin solution, Bouins solution, Hellys solution, Carnoys solution) concerning the acoustical properties of testicular tissue was examined. By means of an ultrasound spectroscopic measurement technique the ultrasound damping was registered by calculation of the ultrasound damping coefficient alpha. The results show that the most lower alpha values were obtained by fixation with formalin solution as well in normal as in altered testicular tissue.

[Experimental studies of the effect of fixation time on ultrasound extinction in formalin-fixed testicular tissue].

The influence of fixation time on the ultrasound damping was investigated in vitro in both normal and altered formalin-fixed testicular tissue. By means of ultrasound spectroscopy the ultrasound damping coefficient alpha is estimated. The results of measurements in different time intervals after onset of fixation did show that in both normal and altered testicular tissue only slight changes of ultrasound damping was found.

[The effect of early urologic complications on the prognosis of kidney transplantation].

The early urological complications of 200 patients receiving a kidney allograft between 1985 and 1987 were analyzed retrospectively. In the first 4 weeks after transplantation urological, complications were found in 25 cases (12.5%), with a portion of 74.

[Ultrasound attenuation as a function of frequency in formalin fixed testicular tissue].

Measurements of the ultrasound attenuation were carried out in 10 normal testes and 20 pathologically changed testicular tissue biopsies in vitro after formalin fixation. The ultrasound attenuation as function of the frequency was recorded ultrasound-spectroscopically about the complete frequency spectrum of the ultrasound-broad range transformer (3-8 MHz). The frequency dependence of the attenuation behaviour differed in the 10 normal testes from the 20 pathologically changed biopsies by smaller values of the ultrasound attenuation coefficient a (linear regression analysis).

[Report of experiences on the use of cyclosporin A].

In September 1985 in our kidney transplantation centre for the first time ciclosporin A was used. Up to now altogether 50 patients received this new form of immunosuppression. During the sand immune application no essential side effects occurred.

[The problem of urinary bladder cancer--an attempt at a therapeutic standard].

The particular uncertainties of the carcinoma of the urinary bladder results from diagnostic and therapeutic deficiencies the causes of which are to be found in the dignity and inclination to dissemination of tumours of the bladder. At present with the help of diagnostic methods which are at our disposal it is difficult to establish an exact clinical staging. Nevertheless it was tried to set certain therapeutic central points.

[Therapy of advanced prostate cancer].

The carcinoma of the prostate gland is a malignant tumour like the other. The locoregional carcinoma of the prostate gland is locally curatively treated with prostatovesiculectomy, percutaneous high-voltage therapy or interstitial radiotherapy. The disseminated diseases of the prostate gland is systemically palliatively treated.

[Transplantation antigen specific rosette test and its inhibition with autologous serum--a new immunologic method for predicting rejection crisis following allogeneic organ transplantation].

A combination of transplantation-antigen-specific rosette test with inhibition of rosette formation, using autologous serum, was used in postoperative follow-up checks on patients who had undergone allogeneic kidney transplantation and proved successful in early diagnosis or prediction of rejection episodes even before clinical manifestation. The numbers of antigen-detecting and antigen-binding cells differed considerably from each other, depending on patients who had undergone kidney transplantation. Almost complete inhibition of antigen detection was generally achieved by addition of patient serum.

[Effect of Iloprost (ZK 36 374) on hemodynamic parameters during kidney donor conditioning in animal experiments].

Hemodynamic parameters during the conditioning of kidney donors were tested under the influence of Iloprost (ZK 36 374), a stable prostacyclin derivate, in 12 house swine of a body weight of 20-50 kg. The electromagnetically measured blood flow in the right renal artery increased on an average of 73.2% after intraaortic infusion of Iloprost (1 micrograms/kg.