Changes of cardiolipin involve in the occurrence and development of mitochondrial dysfunction associated with non-alcoholic fatty liver disease.

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, which is often accompanied by mitochondrial dysfunction. Cardiolipin is a special lipid of mitochondrial inner membrane and any change of cardiolipin may cause series of mitochondria-relevant diseases. Changes in cardiolipin content, fatty acid side chain composition after cardiolipin remodeling, and the content of cardiolipin remodeling enzymes play an important role in the occurrence and development of NAFLD-related mitochondrial dysfunction.