Publications by authors named "Langbiao Liu"
Article Synopsis
- The study aimed to evaluate the safety, feasibility, and short-term effectiveness of λ-type esophagojejunostomy during total gastrectomy using total laparoscopy, focusing on its impact on postoperative quality of life.
- Researchers analyzed data from 50 patients with adenocarcinoma who underwent this procedure, measuring various outcomes such as operation time, recovery times, and complications.
- Results indicated that the procedure had manageable complications and a stable Nutritional Risk Index over 12 months, suggesting it could be a viable option for patients undergoing total gastrectomy.
PD-L1 expression-related PI3K pathway correlates with immunotherapy efficacy in gastric cancer.
Ther Adv Med Oncol
October 2023
Background: The programed death ligand-1 combined positive score (PD-L1 CPS), the only FDA-approved biomarker for immune checkpoint inhibitor therapy in gastric cancer (GC) patients, is an important but imperfect predictive biomarker. The molecular characteristics of tumors that influence the PD-L1 CPS are largely unknown and would be helpful for screening patients who would benefit from immunotherapy.
Methods: PD-L1 immunohistochemistry (IHC) and targeted next-generation sequencing techniques were used to compare genomic alterations in 492 GC patients in two groups (PD-L1 CPS ⩾ 1, positive; CPS < 1, negative).
Background: TP53 is one of the most frequent mutated genes in colon cancer. Although colon cancer with TP53 mutations has a high risk of metastasis and worse prognosis generally, it showed high heterogeneity clinically.
Methods: A total of 1,412 colon adenocarcinoma (COAD) samples were obtained from two RNA-seq cohorts and three microarray cohorts, including the TCGA-COAD ( = 408), the CPTAC-COAD ( = 106), GSE39582 ( = 541), GSE17536 ( = 171) and GSE41258 ( = 186).