WDR68 stimulates cellular proliferation via activating ribosome biogenesis in 293T cells.

WDR68, a conserved WD40 repeat-containing protein, interacts with E1A and is involved in the E1A-induced cell proliferation and oncogenic transformation, but the intrinsic molecular mechanisms of this process remain to be elucidated. Here, we demonstrate that WDR68 promotes the proliferation of 293T cells by interacting with a series of ribosome biogenesis-regulating proteins. Gene Set Enrichment Analysis (GSEA) of RNA-seq data also revealed that the ribosome biogenesis-associated gene signatures could be the most significantly enriched in the WDR68 expression groups.

A Dynamic TDMA Scheduling Strategy for MANETs Based on Service Priority.

Physical resource allocation strategy is a key factor affecting the performance of a mobile ad hoc network (MANET), which serves as a network model widely used in the sensor and detection field. For various perceived service information, it is significant for the allocation strategy to adapt to the dynamic service requirements and prioritize resource access for the service information with high priority to guarantee its real-time performance. In this paper, a novel dynamic time division multiple access (TDMA) scheduling strategy is proposed for MANETs.

DKK3 expression in hepatocytes defines susceptibility to liver steatosis and obesity.

Background & Aims: Dickkopf-3 (DKK3), a protein belonging to the DKK family, has been extensively investigated in the context of cancer, including liver cancer. However, the role of DKK3 in hepatic steatosis and related metabolic disorders remains largely unexplored.

Methods: We detected the expression of DKK3 in the fatty livers of NAFLD patients and of obese mice and investigated the function of DKK3 in hepatic steatosis and related metabolic disorders by using hepatocyte-specific DKK3 deficiency or overexpression obese mice induced by high fat diet (HFD) or genetic defect (ob/ob).