Publications by authors named "Landry E Mombo"
Short tandem repeats (STRs) are repeating DNA sequences used in forensic human identity testing and the diagnosis of aneuploidies. Many STRs like Penta D and TPOX are used routinely for paternity tests, but these tests are not widely used in sub-Saharan Africa. In this study we recruited individuals from Gabonese families seeking a paternity test.
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- Malaria is a significant public health issue in Gabon, particularly in Franceville, necessitating urgent surveillance and early diagnosis for effective treatment.
- A retrospective study from 2017 to 2019 analyzed 2,518 malaria cases, revealing a prevalence of 26.1%, with young children being the most affected demographic.
- The findings indicate a need for targeted malaria control strategies in Franceville due to seasonal and gender disparities in infection rates, alongside the prominence of multiple Plasmodium species.
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- Human T-cell lymphotrophic virus type-1 (HTLV-1) and human immunodeficiency virus (HIV-1) co-infection is common in Gabon, and co-infected individuals tend to progress more rapidly to AIDS.
- * The study involved 299 individuals, revealing a 7.7% prevalence of HTLV-1 infection, with women and older age being risk factors for co-infection.
- * Results indicated higher CD4+ cell counts and a lower HIV-1 viral load in co-infected individuals compared to those with just HIV-1, emphasizing the need for improved prevention and management strategies for co-infections.
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- Neonatal screening for sickle cell disease (SCD) is being successfully implemented in some urban areas of sub-Saharan Africa, but rural regions like Koula-Moutou, Gabon, face unique challenges.
- A study involving 215 women revealed that only 24% were aware of SCD, and 30% consented to neonatal screening, with younger and more educated mothers more likely to approve.
- Cultural and educational barriers, rather than a lack of disease knowledge, hinder acceptance of neonatal screening, highlighting the need for a supportive team of psychosocial and health workers familiar with the local community.
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- This study aimed to assess how socio-clinical factors influence adherence to antiretroviral treatment (ART) among people living with HIV/AIDS in Koula-Moutou, Gabon.
- Two methods were used to evaluate adherence: patient declarations and pharmacy visit compliance, revealing higher patient-reported adherence rates compared to actual pharmacy data.
- The study found a link between better reported adherence and lower education levels and calls for further research on ART adherence factors in this vulnerable population.
Background: In Gabon, universal neonatal screening of sickle cell disease is not carried out in rural areas, often leading to late detection of the disease. However, complete blood counts are available in rural areas.
Materials And Methods: We evaluated the haematological parameters of 45 homozygous steady-state sickle cell anaemia (SCA) patients and compared them with 45 sex- and age-matched Haemoglobin AA controls in Koula-Moutou, a rural area in Eastern Gabon.
Background: Very few studies have been conducted on the seroprevalence of syphilis in Gabon. According to the World Health Organization, the average seroprevalence of syphilis has declined from 5.5 to 1.
View Article and Find Full Text PDFThe five closely linked CD1A-E genes encode the human CD1 family of proteins. Few studies of the allele frequencies of these genes in African populations have been published so far. This study aimed to genotype CD1A and CD1E variants and to compare their frequencies in Sub-Saharan Africans from Gabon and Ivory Coast, and Non-Africans from Syria and France.
View Article and Find Full Text PDFAssessment of rapid diagnostic tests and fourth-generation Enzyme-Linked Immunosorbent Assays in the screening of Human Immunodeficiency and Hepatitis B virus infections among first-time blood donors in Libreville (Gabon).
J Clin Lab Anal
March 2019
Background: Blood transfusion is a pathway for the transmission of blood-borne pathogens such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV) from donors to recipients in most countries in sub-Saharan Africa, including Gabon. The study aimed to compare the performance of four rapid diagnostic tests (RDTs: Alere DETERMINE, BIOSYNEX Exacto Pro HIV, MEDIFF HIV 1&2, and BIOSYNEX IMMUNOQUICK HBsAg) with results of 4th-generation immunoenzymatic assays COBAS 6000 e601 and EVOLIS BioRad for the detection of HIV and hepatitis B surface antigen (HBsAg) in blood donors in Libreville, Gabon.
Methods: Reactive and nonreactive blood samples for HIV and HBsAg were selected using fourth-generation ELISA COBAS 6000 e601 and EVOLIS BioRad.
Despite chronic Hepatitis B virus (HBV) infection being the main cause of younger-onset complex liver disease including cirrhosis and hepatocellular carcinoma (HCC) in Africa, very little is known regarding the seroprevalence of HBV in the Gabonese general population. This investigation aimed to provide strong epidemiological data and risk factors associated with HBV infection in first-time blood donors representative of the urban adult population. The screening of HBsAg was carried out using 4th generation ELISA kits.
View Article and Find Full Text PDFObjective: Given the magnitude of the HIV epidemic infection, many viral and human factors were analyzed, and the most decisive was the variant CCR5-Δ32. The presence of a low HIV prevalence (1.8%) in Gabon in the 1990s, compared to neighboring countries, represents a paradox that led us to search for viral and human genetic variants in this country.
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