Publications by authors named "Landre Djamouko-Djonkam"

Background: Knockdown resistance (kdr) is one of the primary resistance mechanisms present in anopheline species. Although this mutation is largely spread across the Anopheles gambiae s.l.

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Although species are considered to be equally affected by control measures targeting malaria vectors, there is still not enough evidence of the impact of interventions such as larviciding on the distribution of these mosquito species. The present study assessed the impact of a larviciding trial targeting malaria vectors on mosquito species in the city of Yaoundé, Cameroon. A cluster randomized trial comparing 13 treated clusters and 13 untreated clusters was implemented.

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There has been a renewed interest for larviciding during the recent decade. Although biological larvicides are considered not to be harmful to non-target organisms, there is still not sufficient data on the effect of new long-lasting larvicide formulations such as VectoMax G combining and on the environment especially on non-target organisms. The present study aimed to assess the possible influence of VectoMax G on the diversity and abundance of the aquatic fauna cohabiting with mosquito larvae in breeding habitats during a larviciding trial in the city of Yaoundé.

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Article Synopsis
  • Urban malaria is a growing public health issue in Cameroon, prompting a pilot larviciding trial in Yaoundé aimed at reducing mosquito populations and malaria transmission.
  • The study combined quantitative and qualitative methods to assess community perceptions on malaria control, revealing that residents in areas receiving larviciding had better knowledge of malaria transmission and mosquito breeding habits.
  • Results showed that community members were generally supportive of larviciding, noticed reduced mosquito problems, and maintained regular use of bed nets, demonstrating that larviciding can be integrated into overall malaria control efforts without causing negative impacts on existing practices.
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  • Rapid pyrethroid resistance is a major challenge for malaria vector control in Cameroon, with insufficient data on its exact status across the country.
  • The study evaluated resistance profiles through bioassays, species identification, and detection of target site mutations, finding high frequencies of the kdr L1014F allele and some occurrence of the N1575Y mutation in various regions.
  • Overexpression of several detoxification genes and significant differences in cuticular hydrocarbon lipids were noted, highlighting the need for increased research and action to address insecticide resistance in malaria control strategies.
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  • The spread of resistance to pyrethroids in malaria-carrying mosquitoes poses a significant challenge for current malaria control strategies, highlighting a need for alternative insecticides such as carbamates and organophosphates.
  • A study conducted in Cameroon evaluated the resistance levels of Anopheles gambiae mosquitoes to bendiocarb and malathion, using both bioassays and molecular techniques, and found widespread resistance except in specific locations.
  • The research revealed high frequencies of the ace-1 G119S mutation and overexpression of multiple resistance-related genes, indicating that the development of resistance to these alternative insecticides could undermine future malaria control efforts.
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The contribution of Anopheles funestus to malaria transmission in the urban environment is still not well documented. The present study assesses the implication of An. funestus in malaria transmission in two districts, Nsam and Mendong, in the city of Yaoundé.

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Background: Improving house structure is known to limit contact between humans and mosquitoes and reduce malaria transmission risk. In the present study, the influence of house characteristics on mosquito distribution and malaria transmission risk was assessed in the city of Yaoundé.

Methods: The study was conducted from March 2017 to June 2018 in 32 districts of the city of Yaoundé.

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Background: The rapid and unplanned urbanization of African cities is considered to increase the risk of urban malaria transmission. The present study objective was to assess factors influencing the spatio-temporal distribution of Anopheles gambiae s.l.

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Background: Malaria prevention in Cameroon mainly relies on the use of ITNs. Although several free distribution campaigns of treated nets have been conducted across the country, bed net usage remains very low. A household survey was conducted to assess knowledge of the population and practices affecting treated net usage in the city of Yaoundé.

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Background: Culex species are widespread across Cameroon and responsible for high burden of nuisance in most urban settings. However, despite their high nuisance, they remain less studied compared to anophelines. The present study aimed to assess Culex species distribution, susceptibility to insecticide, bionomics and role in Lymphatic Filariasis (LF) transmission in the city of Yaoundé.

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Article Synopsis
  • * A comprehensive study conducted from March 2017 to March 2018 involved trapping and analyzing over 218,000 mosquitoes to understand their species composition, infection rates, and behavior, revealing that outdoor biting rates were considerably higher than indoor.
  • * The findings indicated a high malaria transmission risk, especially outdoors, with certain mosquito populations showing resistance to key insecticides and a prevalence of genetic traits that could affect control efforts, emphasizing the need for enhanced malaria control strategies in urban settings.
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