Colonic histiocytic neoplasm mimicking malignant histiocytosis and presenting as intussusception.

It is now apparent that distinction between the so-called malignant histiocytosis and lymphoma can be made using panels of established immunohistochemical markers and/or genotypic analysis. Many, if not all, of the previously diagnosed cases of malignant histiocytosis have been shown to be of lymphoid, rather than histiocytic, lineage. We report a rare case of colonic histiocytic neoplasm accompanied by a lymphoreticular dissemination that mimicked that of malignant histiocytosis.

Mechanisms of protein activation of the intestinal phase of gastric secretion.

To determine if the secretory response to protein in the gut is due to direct effects of absorbed amino acids on the parietal cells, to hormonal effects, or to a combination of both, Heidenhain pouch secretion and plasma amino nitrogen levels were measured during enteral infusions of casein or liver extract, as well as during intravenous infusions of amino acids, in three dogs with and three dogs without portacaval transposition. In the dogs without portacaval transposition, gastric secretory responses were slight and did not differ significantly; secretory responses were seen only during infusions in which elevations of plasma amino nitrogen values occurred. In dogs with portacaval transposition, secretory responses to both casein and liver extract were significantly higher (P less than 0.

Control of the Zollinger-Ellison syndrome by excision of primary and metastatic tumor.

In a patient with Zollinger-Ellison syndrome, control of the peptic ulcer diathesis was attempted by excision of a small duodenal gastrinoma and removal of three lymph nodes containing metastases. The patient has been asymptomatic for 2.5 years with basal achlorhydria, a normal serum gastrin level and a negative gastrin response to secretin.

Results of surgical management in 92 consecutive patients with Zollinger-Ellison syndrome.

Hospital records and follow-up information on 92 patients with surgically proven Zollinger-Ellison syndrome have been reviewed, and data relating to symptomatology, age and sex incidence, pathologic findings, and early and late results of surgical procedures have been summarized. The postoperative mortality rate was 15%, and was adversely affected by previous peptic ulcer surgery, by the necessity of urgent operation for complications of peptic ulcer, and by employment of a procedure that failed to control acid secretion. Thirteen patients were found to have primary gastrinomas of the duodenum and an additional 13 patients had islet cell hyperplasia without evidence of frank neoplasm; prognosis in these two groups appears to be particularly favorable.

Effect of an intravenous fat preparation on canine gastric secretion.

The effect of intravenous administration of a fat emulsion on canine gastric secretion stimulated by intravenous infusion of amino acids, pentagastrin or insulin was studied. The fat preparation was given at a rate of 30 ml/hour for 2 hours, and its effects were compared with those of a comparable amount of saline solution, each given on three separate occasions in each dog. Fat did not alter the Heidenhain pouch secretion stimulated by intravenous amino acids (1.

Relationship between amino acid dose and gastric secretory response.

Gastric secretory dose-response studies, using an 8.5% mixed L-amino acid solution as the agonist, were carried out in three dogs with Heidenhain pouches and gastric fistulae. Secretory responses of the Heidenhain pouches were measured during two hour infusions of amino acids given at rates of 0, 0.

Amino acids as possible mediators of the intestinal phase of gastric secretion.

In a group of six dogs with Heidenhain pouches, the infusion of a solution of L-amino acids caused identical increases in gastric secretion when given into the jejunum as when administered directly into the portal venous system. Elevations in plasma amino nitrogen were also similar in the two circumstances. In four dogs with Heidenhain pouches and portacaval transposition, a similar infusion caused an identical increase in gastric secretion when given into the jejunum as when given into the peripheral venous system; plasma amino nitrogen levels were almost as high with the jejunal administration as with venous infusion.

Some properties shared by amino acids and entero-oxyntin.

The intestinal phase of gastric secretion has been thought to be due to the release of a hormone from the gut mucosa, and several properties have been attributed to this as-yet unidentified hormone. An amino acid solution, known to stimulate gastric secretion, was tested to see if it possesses several of these properties, i.e.

Gastric secretory response to intravenous amino acids in eviscerated dogs.

Eight dogs, four with intact vagi and four with vagotomy, were studied to see if the gastric secretory effect of intravenously administered L-amino acids is mediated by a gastrointestinal (GI) hormone or hormones. Intravenous infusion of amino acids produced a significant secretory response in denervated and in innervated stomachs. When the known sites of formation of GI hormones were removed by resection of antrum, duodenum, pancreas, jejunum, ileum, and colon, the gastric stimulatory effect of amino acids was not changed significantly in denervated stomachs but was greatly increased in innervated stomachs.

Gastric secretory effect of amino acids given enterally and parenterally in dogs.

To investigate the possible role of absorbed amino acids in the "intestinal phase" of gastric secretion, experiments were carried out in 5 mongrel dogs with Heidenhain pouches, gastrostomies, and Roux en-Y jejunostomises. A 3% solution of mixed amino acids was infused at a constant rate of 120 ml per hr throughout a 2-hr period either intravenously or intrajejunally, and the secretory response of the pouches was compared to that obtained during similar infusions of 0.9% NaCl.

Bile-fat relationships in gastric secretory inhibition and bile flow stimulation.

The effect of intraduodenal infusion of olive oil, bile, or a mixture of olive oil and bile on pentagastrin-stimulated gastric secretion, bile flow, and serum immunoreactive secretin levels was studied in dogs. Bile alone had no effect on gastric secretion, but the mixture of bile and olive oil induced prompt, statistically significant gastric secretory inhibition. Bile had the early choleretic effect that would be expected to result from the absorption of bile salts, whereas the bile--olive oil mixture brought about a delayed amd much greater increase in bile flow rates.

Effect of nicotine on serum secretin and exocrine pancreatic secretion.

The effect of nicotine (100 mug/kg hr-1) on serum secretin and pancreatic secretions was studied in dogs with chronic pancreatic fistulas. Release of immunoreactive secretin (IRS) was stimulated by intraduodenal infusion of HCl (9.6 mEq/30 min).

Somatostatin suppresses secretin and pancreatic exocrine secretion.

Somatostatin, a hypothalamic peptide, suppresses hydrochloric acid-stimulated release of secretin, pancreatic flow rate, and bicarbonate and protein secretion in fasted, conscious dogs. It also reduces nonstimulated pancreatic exocrine secretion but does not affect basal secretin concentrations. Suppression of HCl-stimulated secretin release is complete, whereas pancreatic flow rate and bicarbonate and protein secretions are only partially inhibited.

Changes in canine gastric acid output and serum gastrin levels following massive small intestinal resection.

Vagally denervated (Heidenhain) pouch acid outputs and serum gastrin concentrations, basal and in response to feeding, were measured in dogs before and after massive intestinal resection. Both 24-hr and postprandial Heidenhain pouch acid outputs increased (P less than 0.01) after intestinal resection.