[Thoracic pain, shock-inducing gastrointestinal bleeding].

A 65-year-old patient was referred to hospital with suspected myocardial infarction because of left-sided thoracic pain. A paresis of the left recurrent nerve of unknown etiology has been known for three years. Because of shock with anemia, upper gastrointestinal endoscopy was performed.

[Quantitative determination of dose-response relations of taxol and cisplatin in ovarian cancer cells with a bioassay in comparison with cytomorphology].

The dose-response relations of the cytotoxic drugs taxol and cisplatin and their combination were analyzed in an ovarian cancer cell line (BG-1). The chemosensitivity profiles were obtained with 5 concentrations using the ATP cell viability assay (ATP-CVA). Furthermore, the cytomorphologic changes were analyzed.

Bronchogenic carcinoma mimicking metastatic thyroid carcinoma.

We present a case of a false-positive 131I scan in the follow-up of a patient with papillary thyroid carcinoma, which developed 24 yr after radiation therapy for Hodgkin's disease. In the primary evaluation of a neck mass, histology was typical for a papillary thyroid carcinoma and thyroglobulin staining was positive. After total thyroidectomy, 131I uptake was seen in the hilum and right lung.

[Proliferative myositis--a little-known pseudomalignant lesion].

The leading symptom of proliferative myositis is a rapidly growing hard tumor in the muscle. The disease is rare and therefore widely unknown. We observed a case of proliferative myositis in a 54-year-old female.

[Retinal and vitreal metastasis of a small cell bronchus cancer].

The rare form of retinal metastasis with infiltration of the vitreous is presented in terms of a 47-year-old female patient suffering from an oat cell bronchogenic carcinoma with remote metastasis. Clinical appearance, differential diagnosis, diagnostic evaluation, histology and evolution are discussed.

[Diagnosis of pathologic changes in the liver caused by fine needle puncture].

Needle aspiration biopsy for cytologic detection of tumors and tumor-like lesions of the liver is widely recognized as a safe and highly sensitive method, especially since the introduction of imaging techniques for guidance of the aspirators needle. In the following paper we discuss indications and contraindications of the method; in the context of the articles about cytologic diagnosis of gastrointestinal lesions we write about our own observations and experiences in using this method of guided fine needle aspirations and cytologic examinations of liver lesions.

[Possibilities of cytodiagnosis in ascites].

The examination of ascitic fluid is an important part in the diagnosis and control of gastrointestinal diseases. Different etiological conditions and pathological ways help develop different types of ascitic fluid. Variation of protein content (transudates/exsudates), variation of cells lead to different diagnosis.

[Image-guided thin needle puncture of tumors of the gastrointestinal system. Puncture technique and handling of materials].

The image-guided fine-needle aspiration biopsy in the diagnosis of gastro-intestinal tumors has reached a very high value out of other diagnostic tools. The results of this method depend directly on the technical performance (aspirator, technicians, cytologist) of the punction and processing of the obtained cytological material. The following paper is a brief communication on technical methods and experience in performing the image-guided fine-needle aspiration biopsy at the university hospital of Zurich.

[Disseminated histoplasmosis as the first manifestation of HIV infection].

A 29-year-old man who had been abroad for several years (mainly Mexico) fell ill with fever (up to 39.8 degrees C), night sweats, weight loss of 10 kg in 6 months (height 181 cm, weight 50.5 kg) and abdominal pain.

[Ascites in metastatic neuroendocrine tumor of the intestine. Cytologic and immunocytochemistry diagnosis].

The presence of neuroendocrine tumor cells in ascites is extremely rare. Cytologic specimens of ascites of two patients suffering from this tumor disease were examined. The use of immunocytochemical staining allows to reach a correct diagnosis in cases in which the result of conventional diagnosis remains unsettled.

Pseudoepithelial pattern in smears prepared from fine needle aspirates of plasmacytomas.

A pseudoepithelial pattern was observed in smears prepared from fine needle aspirates (FNA) from three plasmacytomas. In one case cells displayed a markedly granular, 'oncocytic' cytoplasm. Granularity of the cytoplasm was due to a large number of mitochondria as shown by electron microscopy.

Fine needle aspiration of the liver. Significance of hepatocytic naked nuclei in the diagnosis of hepatocellular carcinoma.

Fine needle aspiration (FNA) smears from 60 cases of histologically (34) or clinically (26) confirmed hepatocellular carcinomas were reviewed. In about 90% of the cases, the cytologic preparations contained clusters of malignant cells with variable degrees of hepatocytic features and a distinctive type of naked nuclei. These naked nuclei had features similar to those of the malignant hepatocytes, but with more evident atypia.

[Cytological diagnosis of hepatocellular carcinoma based on ultrasonically guided fine needle biopsy].

1902 ultrasonically guided fine needle aspirations of liver were examined in the Cytology Department of the Institute of Pathology, University Hospital of Zürich, in the period 1977 to March 1987. 75 of the patients had hepatocellular carcinoma which was confirmed by clinical follow-up, laboratory data and/or by histology. In 71 cases (94.