The Ronne Ice Shelf survived the last interglacial.

The fate of the West Antarctic Ice Sheet (WAIS) is the largest cause of uncertainty in long-term sea-level projections. In the last interglacial (LIG) around 125,000 years ago, data suggest that sea level was several metres higher than today, and required a significant contribution from Antarctic ice loss, with WAIS usually implicated. Antarctica and the Southern Ocean were warmer than today, by amounts comparable to those expected by 2100 under moderate to high future warming scenarios.

Initiation of mechanical thrombectomy in an insular setting with helicopter transfer: a 2-year experience from the first, complete, tertiary stroke center in the Caribbean.

Background: This is the first cohort study of patients treated with mechanical thrombectomy (MT) for acute ischemic stroke in the French West Indies, with a mothership center and helicopter transfer.

Objective: To describe the population and to evaluate imaging, clinical, and time metric outcomes, in order to assess the feasibility and adjust the territorial organization.

Methods: In this observational study, we retrospectively analyzed our prospectively collected data of a population of consecutive patients treated with MT for anterior and posterior circulation large vessel occlusions.

Clinical, imaging, and management features of symptomatic carotid web: Insight from CAROWEB registry.

Background: Although carotid web (CaW) is increasingly diagnosed as a cause of cryptogenic stroke, data are still limited to monocentric small sample cohort. To broaden knowledge on symptomatic CaW, CAROWEB registry has been recently implemented.

Aims: In a large cohort of symptomatic CaW patients, we described epidemiologic characteristics, admission clinical and imaging features, and the current management including the secondary preventive strategy choice made in comprehensive French Stroke Units.

Dual-layer carotid stenting for symptomatic carotid web: Results from the Caroweb study.

Background & Purpose: Carotid Web (CaW) is a growingly recognized cause of ischemic stroke, associated with a high recurrence risk. Several therapeutic strategies have been proposed as a tertiary prevention including carotid stenting, endarterectomy and antithrombotic medications. Among these, carotid stenting with dual-layer stent may be promising to adequately cover the focal arterial dysplasia.

Wilkes subglacial basin ice sheet response to Southern Ocean warming during late Pleistocene interglacials.

The response of the East Antarctic Ice Sheet to past intervals of oceanic and atmospheric warming is still not well constrained but is critical for understanding both past and future sea-level change. Furthermore, the ice sheet in the Wilkes Subglacial Basin appears to have undergone thinning and ice discharge events during recent decades. Here we combine glaciological evidence on ice sheet elevation from the TALDICE ice core with offshore sedimentological records and ice sheet modelling experiments to reconstruct the ice dynamics in the Wilkes Subglacial Basin over the past 350,000 years.

Global biosphere primary productivity changes during the past eight glacial cycles.

Global biosphere productivity is the largest uptake flux of atmospheric carbon dioxide (CO), and it plays an important role in past and future carbon cycles. However, global estimation of biosphere productivity remains a challenge. Using the ancient air enclosed in polar ice cores, we present the first 800,000-year record of triple isotopic ratios of atmospheric oxygen, which reflects past global biosphere productivity.

Stroke Recurrence in First-Ever Symptomatic Carotid Web: A Cohort Study.

Background And Purpose: Carotid web (CaW) is an intimal variant of fibromuscular dysplasia responsible for ipsilateral cerebral ischemic events (CIE). Symptomatic CaW likely has a high risk of recurrent CIE, but no salient prospective data are available. We aimed to assess recurrence rate and its predictors after a first-ever CIE.

A 120,000-year long climate record from a NW-Greenland deep ice core at ultra-high resolution.

We report high resolution measurements of the stable isotope ratios of ancient ice (δO, δD) from the North Greenland Eemian deep ice core (NEEM, 77.45° N, 51.06° E).

The anatomy of past abrupt warmings recorded in Greenland ice.

Data availability and temporal resolution make it challenging to unravel the anatomy (duration and temporal phasing) of the Last Glacial abrupt climate changes. Here, we address these limitations by investigating the anatomy of abrupt changes using sub-decadal-scale records from Greenland ice cores. We highlight the absence of a systematic pattern in the anatomy of abrupt changes as recorded in different ice parameters.

Exceptionally high biosphere productivity at the beginning of Marine Isotopic Stage 11.

Significant changes in atmospheric CO over glacial-interglacial cycles have mainly been attributed to the Southern Ocean through physical and biological processes. However, little is known about the contribution of global biosphere productivity, associated with important CO fluxes. Here we present the first high resolution record of ΔO of O in the Antarctic EPICA Dome C ice core over Termination V and Marine Isotopic Stage (MIS) 11 and reconstruct the global oxygen biosphere productivity over the last 445 ka.

A unicorn in Alice in Wonderland syndrome.

We report the case of a 56-year-old man presenting several episodes of body image distortions with a sensation of having a horn growing on his forehead, as a unicorn, corresponding to the Alice in Wonderland syndrome. Brain single-photon emission computed tomography with technetium-99m hexamethylpropyleneamine oxime showed hypoperfusion of the visual primary cortex, expanding to the temporo-occipital junction bilaterally but predominantly on the right side.

Fingolimod for the treatment of multiple sclerosis in French West Indies, a real-world study in patients from African ancestry.

Affecting 2.5 million people worldwide, multiple sclerosis (MS) is one of the main causes of acquired disability among young adults. In French West Indies (FWI), where MS has arisen from the end of the 80's, a low therapeutic response to interferons beta1 (IFN beta1) in patients of African descent, restrains the therapeutic options.

Acute myelitis associated with dengue infection.

Objectives: To present a rare neurological complication of dengue fever.

Patients And Methods: A 24-year-old female presented with acute myelitis seven days after dengue fever onset.

Results: The patient presented with intense fever.

Thrombolytic Therapy of Acute Ischemic Stroke during Early Pregnancy.

Thrombolytic treatment (recombinant tissue plasminogen activator [rt-PA]) has established efficacy in acute ischemic stroke, but pregnancy has been an exclusion criterion for all clinical trials that validated alteplase in acute stroke, so our knowledge about its use in this condition is limited. Herein we report the successful use of intravenous rt-PA thrombolysis, uncomplicated by neither hemorrhage development nor other complication in a woman who was 13 weeks pregnant with acute ischemic stroke. The brain magnetic resonance imaging diffusion-weighted sequences showed increased signal in the territory of the left middle cerebral artery.

ZIKA vasculitis: A new cause of stroke in children?

Viral infectious vasculitis is a cause of stroke in children. Zika virus infection is often asymptomatic. Neurological complications have however been reported: Guillain-Barré, ADEM, meningoencephalitis, myelitis, microcephaly in the fetus of infected mothers.

A case of lymphoma in a patient on teriflunomide treatment for relapsing multiple sclerosis.

Teriflunomide is an oral therapy approved for relapsing forms of multiple sclerosis which has been shown to reduce relapse rate and disability progression. We report the case of a 54-year -old black woman with multiple sclerosis who developed follicular lymphoma after about 8 months of exposure to teriflunomide. Importantly, apart from age, the patient had none of the established risk factors for follicular lymphoma.

Direct, Precise Measurements of Isotopologue Abundance Ratios in CO Using Molecular Absorption Spectroscopy: Application to ΔO.

We present an ultrasensitive absorption spectrometer based on a 30 Hz/s stability, sub-kHz line width laser source coupled to a high-stability cavity-ring-down-spectroscopy setup. It provides direct and precise measurements of the isotopic ratios δO and δO in CO. We demonstrate the first optical absorption measurements of O anomalies in CO with a precision better than 10 ppm, matching the requirements for paleo-environmental applications.

The impact of Last Glacial climate variability in west-European loess revealed by radiocarbon dating of fossil earthworm granules.

The characterization of Last Glacial millennial-timescale warming phases, known as interstadials or Dansgaard-Oeschger events, requires precise chronologies for the study of paleoclimate records. On the European continent, such chronologies are only available for several Last Glacial pollen and rare speleothem archives principally located in the Mediterranean domain. Farther north, in continental lowlands, numerous high-resolution records of loess and paleosols sequences show a consistent environmental response to stadial-interstadial cycles.

Evaluation of financial burden following complications after major surgery in France: Potential return after perioperative goal-directed therapy.

Objective: Perioperative goal-directed therapy (PGDT) has been demonstrated to improve postoperative outcomes and reduce the length of hospital stays. The objective of our analysis was to evaluate the cost of complications, derived from French hospital payments, and calculate the potential cost savings and length of hospital stay reductions.

Methods: The billing of 2388 patients who underwent scheduled high-risk surgery (i.

Psychiatric comorbidity in temporal DNET and improvement after surgery.

Background: "Alien tissue" may be responsible for a higher frequency of psychiatric disorders in patients with temporal lobe epilepsy (TLE). Also, ganglioglioma and dysembryoplastic neuroepithelial tumors (DNET) could represent a risk-factor for the development of post-surgical psychoses. Classically, severe psychiatric disorders contra-indicate epilepsy surgery.