Publications by authors named "Lance R Levine"
J Bone Miner Res
May 2002
Article Synopsis
- PTH treatment led to a significant increase in bone mineral density (BMD) in C57BL/6J mice, particularly in the tibia and femur, with observable effects within 1-2 weeks and continuing increases over 7 weeks.
- The study also showed that while both trabecular and cortical bone parameters improved with PTH treatment, the effects were less pronounced in the lumbar vertebrae, where significant changes only appeared after 7 weeks.
- Increased gene expression related to bone formation and turnover was noted in the long bones, indicating an anabolic action of PTH at both the tissue and cellular levels.
