Publications by authors named "Lance Lehman"
Article Synopsis
- The mitochondrial fission protein Drp1 has multiple isoforms produced through alternative splicing, with longer variants found in neurons that include unique sequences (A-insert and B-insert) whose functions are still unclear.
- Research shows that these inserts affect how Drp1 molecules group together and their ability to function on cell membranes, reducing their overall GTPase activity.
- The membrane protein Mff recruits Drp1 for mitochondrial fission and has differing impacts on Drp1 isoforms, influenced by the presence of the lipid cardiolipin, enhancing the function of the longer isoforms while having limited and sometimes negative effects on the shorter variant.
