Publications by authors named "Lance D Reynolds"
Article Synopsis
- Non-homologous end joining (NHEJ) is a crucial process for fixing DNA double strand breaks during the V(D)J recombination in immune cells.
- The study finds that the loss of the senataxin helicase leads to difficulties in repairing these breaks, particularly when the DNA-PKcs is inactive.
- It also reveals that senataxin works closely with other helicases like RECQL5 and translocases like HLTF, suggesting multiple backup systems are in place for effective NHEJ repair involving ATM and DNA-PKcs.
