Publications by authors named "Lana C Santos"
Article Synopsis
- * A search of patents revealed 411 related to TB vaccines, with 10 focusing specifically on viral vectors, primarily adenoviruses, showing a peak in filings from 2013 to 2023, mainly from the U.S. and China.
- * Most patents included immunodominant Mtb antigens and were primarily tested in mouse models through intranasal or subcutaneous immunization, indicating a hopeful future for these technologies in TB vaccination and other diseases, alongside a need for safety evaluations.
Objectives: Atherosclerosis is an underlying cause of cardiovascular disease, and obesity is one of the risk factors for atherogenesis. Although a gluten-free diet (GFD) has gained popularity as a strategy for weight loss, little is known about the effects of gluten on obesity. We have previously shown a negative effect of gluten on obesity in mice.
View Article and Find Full Text PDFButyrate is a 4-carbon fatty acid that has antiinflammatory and antioxidative properties. It has been demonstrated that butyrate is able to reduce atherosclerotic development in animal models by reducing inflammatory factors. However, the contribution of its antioxidative effects of butyrate on atherogenesis has not yet been studied.
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- Ulcerative colitis (UC) is linked to higher cardiovascular disease (CVD) risks, and this study focuses on women with UC in remission and how different drug treatments affect this risk.
- Twenty-one women participated, with 12 on aminosalicylates and 9 on azathioprine plus aminosalicylates, and key measures included blood pressure, body composition, and immune markers.
- Results showed increased body fat and inflammation in UC groups compared to controls, with azathioprine users exhibiting improved inflammatory regulation, indicating a potentially lower CVD risk compared to those on aminosalicylates alone.