A prediction model based on dual-layer spectral detector computed tomography for distinguishing nonluminal from luminal invasive breast cancer.

Background: The identification of the molecular subtypes of breast cancer is critical to determining appropriate treatment strategies and assessing prognosis. This study aimed to evaluate the ability of dual-layer spectral detector computed tomography (DLCT) metrics to differentiate luminal from nonluminal invasive breast cancer.

Methods: A total of 220 patients with invasive breast cancer who underwent routine DLCT examination were included in the study.

Characterization and expression analysis of heat shock proteins HfHspc1 and HfHspc4 in Haemaphysalis flava ticks.

In this study, the cDNAs of heat shock cognate 90 protein 1 (HfHspc1) and heat shock cognate 90 protein 4 (HfHspc4) from Haemaphysalis flava (Acari: Ixodidae) were obtained using the rapid amplification of cDNA ends (RACE) approach, and the expression patterns of HfHspc1 and HfHspc4 in different developmental stages, engorgement stages and tick organs were analyzed by qPCR. The full length of HfHspc1 was 2411 bp, and its open reading frame (ORF) was 2196 bp, encoding a protein of 732 aa, containing five HSPC family signatures, with MEEVD motif at its extreme C-terminal. The full length of HfHspc4 was 2800 bp, and its ORF was 2364 bp, encoding a protein of 789 aa, containing a signal peptide and five family signatures, with HEEL motif at its extreme C-terminal.

Identification and expression analysis of lncRNAs in rice roots (Oryza sativa L.) under elevated CO concentration and/or cadmium stress.

The gradual rise of CO is one of the global climate changes, Cd stress is also a major abiotic stress factor that affects rice (Oryza sativa L.). The rice seedlings were treated under two CO concentrations and two CdCl concentrations for 7 days (treatments names: 400 ± 20 μmol mol CO and 0 μmol L CdCl concentrations, AC; 400 ± 20 μmol mol CO and 150 μmol L CdCl concentrations, Cd; 800 ± 20 μmol mol CO and 0 μmol L CdCl concentrations, EC; 800 ± 20 μmol mol CO and 150 μmol L CdCl concentrations, EC + Cd).

Preclinical evaluation on human platelet lysate for the treatment of secondary injury following intracerebral hemorrhage.

Intracerebral hemorrhage (ICH) is a condition with high mortality and disability. Secondary injury processes following ICH include neuroinflammation, oxidative stress, and neuronal apoptosis. Human platelet lysate (HPL), derived from crushed platelets, is rich in cytokines and has demonstrated therapeutic potential in neurological disorders in several studies.

Flexible Piezoelectric Sensor Enhanced by Ordered Piezoelectric Composite Material for Three-Dimensional Force Detection.

With the rapid development of intelligent devices, the demand for high-performance flexible sensors with three-dimensional force perception capabilities has become increasingly prominent. In this study, we utilized dielectrophoresis regulation to achieve an ordered arrangement of lead zirconate titanate particles in piezoelectric composite films, enhancing the pressure sensitivity by approximately 4.06 times compared to randomly distributed composite films.

Acupuncture and Moxibustion in the Treatment of Gynecological Perioperative Anxiety: A Systematic Review and Meta-Analysis.

Objective: This systematic review and meta-analysis aims to investigate the effectiveness and safety of acupuncture and moxibustion in managing perioperative anxiety during gynecological surgery.

Methods: Relevant studies published from the establishment of the databases to March 20, 2023, were searched in PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, VIP, and CBM. Literature screening and data extraction were independently conducted by two investigators.

Traumatic brain injury: Advances in coagulopathy (Review).

Trauma is a prevalent cause of coagulopathy, with traumatic brain injury (TBI) accompanied by coagulation disorders particularly linked to adverse outcomes. TBI is distinguished by minimal bleeding volume and unique injury sites, which precipitate complex coagulation disturbances. Historically, research into trauma-induced coagulopathy has primarily concentrated on the molecular biology and pathophysiology of endogenous anticoagulation and inflammation.

Integrating spatial and temporal features for enhanced artifact removal in multi-channel EEG recordings.

Various artifacts in electroencephalography (EEG) are a big hurdle to prevent brain-computer interfaces from real-life usage. Recently, deep learning-based EEG denoising methods have shown excellent performance. However, existing deep network designs inadequately leverage inter-channel relationships in processing multi-channel EEG signals.

Size-tailored and acid-degradable polyvinyl alcohol microgels for inhalation therapy of bacterial pneumonia.

Administration of antibiotics inhalation is considered an effective strategy for pneumonia treatment; however, it encounters challenges related to the development of drug formulations with precise particle sizes and controlled release profiles. Herein, size-tailored and acid-degradable polyvinyl alcohol (PVA) microgels are utilized for nebulized inhalation delivery of piperacillin (PIP) antibiotics to effectively treat pneumonia. These microgels loaded with PIP (G@PIP) were prepared through the UV-crosslinking of thermo-triggered vinyl ether methacrylate-functionalized PVA (PVA) micro-aggregates in aqueous solution.

Process evaluation of an mHealth-based school education program to reduce salt intake scaling up in China (EduSaltS): a mixed methods study using the RE-AIM framework.

Background: An mHealth-based school health education platform (EduSaltS) was promoted in real-world China to reduce salt intake among children and their families. This progress evaluation explores its implementation process and influencing factors using mixed methods.

Methods: The mixed-methods process evaluation employed the RE-AIM framework.

Generating Biomedical Hypothesis With Spatiotemporal Transformers.

Generating biomedical hypotheses is a difficult task as it requires uncovering the implicit associations between massive scientific terms from a large body of published literature. A recent line of Hypothesis Generation (HG) approaches - temporal graph-based approaches - have shown great success in modeling temporal evolution of term-pair relationships. However, these approaches model the temporal evolution of each term or term-pair with Recurrent Neural Network (RNN) independently, which neglects the rich covariation among all terms or term-pairs while ignoring direct dependencies between any two timesteps in a temporal sequence.

Psychological impacts of lobectomy and total thyroidectomy in PTC measuring 1 to 4 cm with low to intermediate risk of recurrence.

Purpose: To investigate the implications of Lobectomy (LT) or total thyroidectomy (TT) on psychological distress and sleep quality in PTC patients with a low to intermediate risk of recurrence and tumors measuring 1 to 4 cm.

Methods: Patients who were admitted to our hospital between July 2021 and July 2022 were prospectively enrolled in this survey. Psychological distress and sleep quality were assessed at hospitalization, discharge, and 1, 3, and 6 months post-treatment using validated scales.

Xinyang flavivirus, from ticks in Henan Province, China, defines a basal, likely tick-only clade.

Tick-borne orthoflaviviruses (TBFs) are classified into three conventional groups based on genetics and ecology: mammalian, seabird and probable-TBF group. Recently, a fourth basal group has been identified in ticks from Africa: Mpulungu flavivirus (MPFV) in Zambia and Ngoye virus (NGOV) in Senegal. Despite attempts, isolating these viruses in vertebrate and invertebrate cell lines or intracerebral injection of newborn mice with virus-containing homogenates has remained unsuccessful.

Multiomic analyses reveal key sectors of jasmonate-mediated defense responses in rice.

The phytohormone jasmonate (JA) plays a central role in plant defenses against biotic stressors. However, our knowledge of the JA signaling pathway in rice (Oryza sativa) remains incomplete. Here, we integrated multiomic data from three tissues to characterize the functional modules involved in organizing JA-responsive genes.

Psychological impacts of thermal ablation and conventional thyroidectomy in BTN patients: a prospective observational study.

Background: Thermal ablation and conventional thyroidectomy are effective therapeutic methods for treating benign thyroid nodules (BTNs), but the psychological impacts of these methods in BTN patients are largely unknown.

Materials And Methods: This survey study prospectively enrolled patients who were admitted to our hospital between July 2021 and July 2022. The four validated scales were applied to quantify psychological distress and sleep quality at five points (the day admitted to the hospital, the day discharged from the hospital, and 1, 3, and 6 months after treatment).

[Significance of Gene Rearrangement in Surveillance of Minimal Residual Disease after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma].

Objective: To investigate the value of immunoglobulin heavy chain () gene rearrangement in monitoring minimal residual disease (MRD) in multiple myeloma (MM) received autologous hematopoietic stem cell transplantation(auto-HSCT).

Methods: The clinical data of 26 MM patients who received auto-HSCT in the Department of Hematology, Wuhan First Hospital from 2018 to 2022 were collected. rearrangement was detected by multiplex PCR combined with capillary electrophoresis fragment analysis to evaluate minimal residual disease (MRD), and the outcome of the disease was analyzed statistically.

PVDF Nanofiber Modified with ZnO Nanowires/Polydopamine for the Treatment of Sewage Containing Heavy Metals, Organic Dyes, and Bacteria.

In various countries worldwide, the issue of wastewater contamination poses a significant threat due to its intricate composition of heavy metals, organic dyes, and microorganisms, thereby complicating the purification process. Consequently, researchers have expressed considerable interest in materials capable of eliminating organic, heavy metal, and microbial pollutants. This study focuses on the fabrication of a water purification membrane (PDA/ZnO-NWs/PVDF) with a hierarchical structure and the ability to remove multiple pollutants.

The OsBZR1-OsSPX1/2 module fine-tunes the growth-immunity trade-off in adaptation to phosphate availability in rice.

The growth-promoting hormones brassinosteroids (BRs) and their key signaling component BZR1 play a vital role in balancing normal growth and defense reactions. Here, we discovered that BRs and OsBZR1 upregulated sakuranetin accumulation and conferred basal defense against Magnaporthe oryzae infection under normal conditions. Resource shortages, including phosphate (Pi) deficiency, potentially disrupt this growth-defense balance.

[Adaptation of the electron transport chain improves the biocatalytic efficiency of progesterone 17α hydroxylation].

17α hydroxylase is a key enzyme for the conversion of progesterone to prepare various progestational drug intermediates. To improve the specific hydroxylation capability of this enzyme in steroid biocatalysis, the CYP260A1 derived from cellulose-mucilaginous bacteria Soce56 and the Fpr and bovine adrenal-derived Adx derived from str. K-12 were used to construct a new electron transfer system for the conversion of progesterone.

Flexible Platform Composed of T-Shaped Micropyramid Patterns toward a Waterproof Sensing Interface.

Antifouling is essential to guaranteeing the sensitivity and precision of flexible sensing interfaces. Materials and structures are the two primary strategies. However, optimizing the inherent microstructures to integrate waterproofing and sensing is rarely reported.

Whole Exome Sequencing reveals clinically important pathogenic mutations in DNA repair genes across lung cancer patients.

Lung cancer remains a substantial health challenge, with distinct genetic factors influencing disease susceptibility and progression. This study aimed to decipher the landscape of DNA repair gene mutations in Pakistani lung cancer patients using Whole Exome Sequencing (WES) and to investigate their potential functional implications through downstream analyses. WES analysis of genomic DNA from 15 lung cancer patients identified clinically important pathogenic mutations in 6 DNA repair genes, including, BReast CAncer gene 1 (BRCA1), BReast CAncer gene 2 (BRCA2), Excision Repair Cross Complementing rodent repair deficiency, complementation group 6 (ERCC6), Checkpoint Kinase 1 (CHEK1), mutY DNA glycosylase (MUTYH), and RAD51D (RAD51 Paralog D).

[Chemotherapy Combined with Venetoclax Followed by Allo-Hematopoietic Stem Cell Transplantation for Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm].

Objective: To investigate the efficacy and safety of chemotherapy combined with venetoclax followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT) for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN).

Methods: The clinical data of 3 patients with BPDCN undergoing allo-HSCT in Department of Hematology, Wuhan First Hospital from July 2017 to November 2021 were collected and retrospectively analyzed.

Results: Among the 3 patients, there were 1 male and 2 females, aged 27-52 years old.

Construction of 2D/1D CuS nanosheets/MnCdS nanorods heterojunction for highly efficient photocatalytic hydrogen evolution.

Developing cost-effective cocatalyst-modified photocatalytic systems with boosted carrier separation and rapid surface catalytic reaction is an ideal strategy for effectively converting solar energy into desired fuels. Herein, a series of CuS/MnCdS hierarchical heterostructures are designed and fabricated to achieve efficient and robust photocatalytic H evolution by coupling one-dimensional (1D) MnCdS nanorods with two-dimensional (2D) CuS nanosheets through a facile sonochemical strategy. Benefiting from dimensionality and cocatalyst effects, the constructed 2D/1D CuS/MnCdS heterojunction photocatalyst containing 1.