Publications by authors named "Lan-tao Wang"
A simple and sensitive LC-MS/MS method for therapeutic drug monitoring of digoxin in children.
J Chromatogr B Analyt Technol Biomed Life Sci
April 2023
This short communication introduced a simple and sensitive LC-MS/MS method for therapeutic drug monitoring of digoxin in children with the lower limit of quantitation of 0.2 ng/mL based on 30 μL of plasma. The plasma sample was pretreated by one-step protein precipitation.
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- - The study investigates potential biomarkers for diabetes-related sepsis (DRS) by analyzing gene expression data from multiple datasets, identifying differentially expressed genes (DEGs) related to both diabetes and sepsis.
- - Using methods like gene set enrichment analysis (GSEA) and weighted gene co-expression network analysis (WGCNA), researchers explored key functional pathways and modules that connect diabetes and sepsis, revealing important biological processes and hub genes involved in DRS development.
- - The findings highlight 7457 diabetes-related DEGs and 2606 sepsis-related DEGs, with specific modules linked to metabolic processes and oxidative phosphorylation, and validate the significance of identified hub genes through both mouse models and a neural network prediction model. *
Background: The aim of the present study was to evaluate the therapeutic effect of high-flow nasal cannula (HFNC) oxygen therapy on patients with aspiration pneumonia accompanied by respiratory failure in the post-stroke sequelae stage, with the goal of providing more effective oxygen therapy and improving patient prognosis.
Methods: Retrospective analysis was conducted on 103 elderly patients with post-stroke aspiration pneumonia and moderate respiratory failure (oxygenation index: 100-200 mmHg) that had been admitted. The patients were divided into two groups according to the mode of oxygen therapy that was used: the Venturi mask group and the HFNC treatment group.
[Comparison of the effect of fluid resuscitation as guided either by lactate clearance rate or by central venous oxygen saturation in patients with sepsis].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
October 2013
Objective: To compare the efficacy of fluid resuscitation as guided by lactate clearance rate (LCR) and central venous oxygen saturation (ScvO2) in patients with sepsis.
Methods: A prospective randomized control study was conducted. Fifty patients diagnosed with severe sepsis or septic shock from January 2011 to February 2012 in department of critical care medicine of Fourth Hospital of Hebei Medical University were enrolled in the study.
[Changes in adrenal cortex function and protective effect of dexamethasone in septic rats during early phases].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
January 2009
Objective: To affirm the presence of relative adrenal insufficiency (RAI) in the early phases of sepsis and its probable mechanisms, and to study the optimal time for glucocorticoid replacement therapy.
Methods: A total of 260 healthy male Wistar rats were randomized into five groups (each group n=52), including normal control group, sham operation group, cecal ligation and puncture (CLP) group, dexamethasone prevention group (with 10 mg/kg dexamethasone injection into the abdominal cavity before CLP) and dexamethasone treatment group (with 10 mg/kg dexamethasone injection into the abdominal cavity 7 hours after CLP). Each group was subdivided into five subgroups according to five time points: 2, 4, 6, 8 and 12 hours.