Ethyl 5-methyl-imidazo[1,2-a]pyridine-2-carboxyl-ate.

The title compound, C(11)H(12)N(2)O(2), was synthesized from the reaction of 6-methyl-pyridin-2-amine and ethyl 3-bromo-2-oxopropionate. In the mol-ecular structure, the six- and five-membered rings are individually almost planar with r.m.

[Intensive insulin therapy in critically ill patients].

Objective: To observe the effect of intensive insulin therapy on improving the condition of critically ill patients.

Methods: A prospective, randomized, controlled study involving adults receiving mechanical ventilation was performed. On admission, critically ill patients were randomly assigned to receive intensive insulin therapy (infusion of insulin only if the blood glucose level exceeded 6.

[Effects of nucleotides on apoptosis of thymocytes].

Objective: To study the effects of nucleotides on apoptosis of thymocytes in mice.

Methods: Apoptosis model in vivo was first established and 25 KM mice, 4 weeks old, were randomly divided into 5 groups. One group was control, and the others were test groups.

[Effect and mechanism of arsenic trioxide on chemosensitivity of human lung adenocarcinoma cells].

Objective: To study the apoptosis and chemosensitive effect of As(2)O(3) on human lung adenocarcinoma cell line A549.

Methods: MTT colorimetric assay, immunohistochemical method, flow cytometry and RT-PCR were applied to observe the different effects induced by As(2)O(3) with different concentrations on A549 cells.

Results: 1, 2 micro mol/L As(2)O(3) increased Fas expression and inhibited the expression of bcl-2, MRP and LRP; G(1) arrest was observed and the cells were more sensitive to cisplatin.