Publications by authors named "Lan-Zhen Huang"
Article Synopsis
- A novel dammarane triterpenoid saponin, Cypaliuruside F, was isolated from leaves and examined for its antitumor effects on HepG2 liver cancer cells using various assays like MTT and flow cytometry.
- The study involved network pharmacology and molecular docking to identify key targets of Cypaliuruside F in fighting hepatocellular carcinoma (HCC).
- Results showed that Cypaliuruside F hinders HepG2 cell growth by triggering apoptosis and cell cycle arrest, primarily by downregulating mTOR, STAT3, and Bcl-2 while enhancing Bax expression.
[Mechanism study on anti-proliferative effects of curcumol in human hepatocarcinoma HepG2 cells].
Zhongguo Zhong Yao Za Zhi
June 2013
Objective: To investigate the anti-proliferative effects of curcumol, an herbal extract from curcuma, in human hepatocarcinoma HepG2 cells, and its possible molecular mechanism.
Method: The effects of curcumol on human hepatocarcinoma cells were assessed in vitro. Proliferation of HepG2 cells treated with various concentration (2.