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Publications by authors named "Lan-Yi Hu"

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Affinity binding of COVID-19 drug candidates (chloroquine/hydroxychloroquine) and serum albumin: Based on photochemistry and molecular docking.
Lan-Yi Hu Ye Yuan Zi-Xuan Wen Yi-Yue Hu Miao-Miao Yin Yan-Jun Hu

J Photochem Photobiol B

March 2023

Article Synopsis
  • Chloroquine (CQ) and hydroxychloroquine (HCQ) initially showed promise in treating COVID-19 but are now discouraged due to side effects.
  • This study examines how these drugs interact with serum albumin (SA), a protein that affects medication efficacy, using biochemical methods and computer simulations.
  • The findings indicate weak binding between the drugs and SA, with CQ binding to multiple sites on the protein, while HCQ primarily binds to one, which could inform drug design for safer CQ derivatives aimed at treating COVID-19.
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