Publications by authors named "Lan-Ting Zhou"
Ethnopharmacological Relevance: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease among old adults. As a traditional Chinese medicine, the herbal decoction Tian-Si-Yin consists of Morinda officinalis How. and Cuscuta chinensis Lam.
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- Neuron-glia interactions are essential for maintaining brain health and are disrupted in neurodegenerative diseases like Alzheimer's.
- Researchers found that neurons in models of Alzheimer's disease show increased levels of adenosine receptor 1 (A1R), which is linked to tau protein pathology and is regulated by a specific microRNA.
- Targeting the A1R signaling pathway and restoring balance in neuron-glia communication could lead to new treatments for Alzheimer’s disease by improving memory and reducing neurodegeneration.
Cholinergic degeneration is one of the key pathological hallmarks of Alzheimer's disease (AD), a condition that is characterized by synaptic disorders and memory impairments. Nerve growth factor (NGF) is secreted in brain regions that receive projections from the basal forebrain cholinergic neurons. The trophic effects of NGF rely on the appropriate maturation of NGF from its precursor, proNGF.
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- Incidence of brain bleeding and iron buildup in the brain increases as people get older, leading to damage and stress for brain cells.
- A study found that a protein called Ferroportin1 (Fpn) is linked to how iron moves in the brain after bleeding, and that changing its levels can help improve symptoms in mice.
- The study also identified a specific molecule, miR-124, that affects Fpn levels, suggesting that blocking miR-124 could help reduce iron buildup and brain cell death in older patients who have experienced brain bleeding.
Neurotoxicity is one of the major pathological changes in multiple neurological disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD), the second popular neurodegenerative disease in aged people. It is known that the AD and PD share the similar neuropathological hallmarks, such as the oxidative stress, loss of specific neurons, and aggregation of specific proteins. However, there are no effective therapeutic drugs for both AD and PD yet.
View Article and Find Full Text PDFImpairments of dendritic trees and spines have been found in many neurodegenerative diseases, including Alzheimer's disease (AD), in which the deficits of melatonin signal pathway were reported. Melatonin receptor 2 (MT2) is widely expressed in the hippocampus and mediates the biological functions of melatonin. It is known that melatonin application is protective to dendritic abnormalities in AD.
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