Synthesis, characterization and anticancer, antibacterial activities of pentacyclic triterpenoid glycoside derivatives.

As a kind of glycoside, pentacyclic triterpenoid saponins have good biological activities, such as anticancer, antibacterial, antiviral and hypoglycemic effects [1]. In this paper, twenty-four pentacyclic triterpenoid derivatives, including twelve monosaccharide derivatives, were designed and synthesized. The anticancer effect and antibacterial activities of all compounds were evaluated.

Synthesis, characterization and antiproliferative effects of isosteviol derivatives.

Nineteen isosteviol derivatives were designed and synthesized by C-16, C-19 and D-ring modifications of isosteviol. These compounds were screened for their cytotoxic activities against Hela and A549 cells . Among them, the inhibitory effect of compounds and on Hela cells was comparable to that of the positive control gefitinib, and the compounds (IC=7.

Two new stilbene glucosides and a new benzoic acid derivative from .

Two new stilbene glucosides, -3,5-dihydroxy-4-methoxystilbene 3--D-glucopyranoside (), -3,5-dihydroxy-4-methoxystilbene 3--D-glucopyranoside (), one new benzoic acid derivative, -4-hydroxy-3-hydroxymethyl-2-butenyl benzoate 4--D-glucopyranoside (), and four known compounds () were isolated from L. The structures of these compounds were elucidated on the basis of spectral data. Anti-inflammatory effects of compounds () were evaluated in terms of inhibition on production of NO, TNF-α and IL-6 in LPS-induced RAW 264.