Publications by authors named "Lan-Hua Li"

Inpatient falls are common adverse events especially for patients with hematologic malignancies. A fall-risk prediction model for patients with hematologic malignancies are still needed. Here we conducted a multicenter study that prospectively included 516 hospitalized patients with hematologic malignancies, and developed a nomogram for fall risk prediction.

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  • Paragonimiasis is a disease caused by two types of parasites in China, and it's mostly spread through food.
  • Many people and animals in China have been infected, especially kids and teens.
  • The infections are more common in warm, rainy areas with lower altitudes, and different types of parasites are found in different parts of the country.
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Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonosis caused by the SFTS virus (SFTSV). Understanding the prevalence of SFTSV RNA in humans, vertebrate hosts and ticks is crucial for SFTS control.

Methods: A systematic review and meta-analysis were conducted to determine the prevalence of SFTSV RNA in humans, vertebrate hosts and questing ticks.

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  • The study aimed to enhance predictions of dengue fever in Singapore by using machine learning to analyze meteorological data, addressing previous research limitations in understanding the relationship between weather changes and dengue transmission.
  • Utilizing weekly data from 2012 to 2022, various machine learning algorithms were tested, with the XGBoost model showing the highest predictive accuracy, strongly relating dengue cases to factors like solar radiation and rainfall.
  • The findings indicate that over the past decade, weather conditions have played a crucial role in dengue transmission, emphasizing the importance of using advanced algorithms to identify key environmental predictors.
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Background: Clonorchis sinensis, one of the most important food-borne zoonotic trematodes, remains prevalent in China. Understanding its infection status in animals is crucial for controlling human clonorchiasis. Here we conducted a systematic review and meta-analysis to focus on the spatio-temporal disparities of C.

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  • Zoonotic infections are a growing global health concern, varying widely in prevalence and transmission due to differences in species, geographical distribution, and vectors like ticks.
  • A systematic review and meta-analysis was conducted to estimate and analyze the global nucleic acid prevalence of zoonotic species in humans, animals, and ticks, pulling data from multiple sources up to December 2021.
  • The findings indicated low overall nucleic acid prevalence in humans (1.93%), animals (ranging from 2.12% to 7.80%), and questing ticks (up to 2.30%), while recognizing that factors like population type and detection methods influenced results but left a significant amount of unexplained variability.
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  • Snail control is essential for managing schistosomiasis in China, yet the resurgence of the Oncomelania hupensis snail poses a challenge, prompting research into their population dynamics and dispersal using genetics and geography.
  • The study involved sampling snails from 45 counties in Sichuan Province, analyzing their genetic sequences to identify unique haplotypes, and utilizing GIS to map their habitats and assess gene flow barriers across the landscape.
  • Findings revealed that the snails display high genetic diversity and can disperse across watersheds, with most habitats located in flat areas, indicating a significant relationship between watercourse proximity and snail density.
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Background: Dengue has become one of the major vector-borne diseases, which has been an important public health concern. We aimed to estimate the disease burden of dengue in major endemic regions from 1990 to 2019, and explore the impact pattern of the socioeconomic factors on the burden of dengue based on the global burden of diseases, injuries, and risk factors study 2019 (GBD 2019).

Methods: Using the analytical strategies and data from the GBD 2019, we described the incidence and disability-adjusted life years (DALYs) of dengue in major endemic regions from 1990 to 2019.

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Human sparganosis is a food-borne parasitic disease caused by the plerocercoids of Spirometra species. Clinical diagnosis of sparganosis is crucial for effective treatment, thus it is important to identify sensitive and specific antigens of plerocercoids. The aim of the current study was to identify and characterize the immunogenic proteins of Spirometra erinaceieuropaei plerocercoids that were recognized by patient sera.

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To reveal the genetic diversity of Babesia microti and Theileria orientalis in Southwest China, we conducted a molecular survey of piroplasms in hard ticks in a China-Myanmar border county. Host infesting and questing ticks were collected from Tengchong County in 2013 and 2014. Piroplasm infection in ticks was detected by PCR, and then, phylogenetic analysis was conducted to study the genetic diversity of the pathogens identified in ticks.

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  • Gut microbes help in digestion and nutrient absorption, but research on freshwater snails like Pomacea canaliculata is limited; studying their microbiota can shed light on the snail's invasive behavior.* -
  • In a study of P. canaliculata, microbiota diversity was highest in the intestine and lowest in the buccal mass, identifying 29 phyla and 111 genera of bacteria, with Ochrobactrum being the most abundant.* -
  • The gut microbiome composition varies across different gut sections, indicating that specific bacteria, particularly cellulose-degrading types, thrive in the snail's digestive system.*
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Recently, both of the species of tick-borne parasites and cases of tick-borne parasitic diseases in human beings are increasing in China. Tick-borne diseases are considered to be an important public health problem affecting the health of Chinese. In this paper, we summarize the epidemic status and control measures of tick-borne parasitic diseases in China, and put forward that the epidemic status of tick-borne parasitic diseases may be greatly underestimated in China, and the systematic surveillance of tick-borne parasitic diseases on population, vectors and animal hosts is urgently needed.

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  • The study aims to explore the current trends and research focus regarding the intestinal flora of snails, analyzing literature from 1998 to 2017.
  • A total of 139 articles were reviewed, highlighting key contributors like the U.S., Brazil, and South Korea, with significant institutions being Kyung Hee University and Oxford University.
  • Key research areas identified include the diversity and function of snail intestinal flora, with relevant keywords such as cellulose and species nova, alongside five highly cited papers and distinct study clusters.
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Background: Many tick species have great morphological similarity and are thus grouped into species complexes. Molecular methods are therefore useful in the classification and identification of ticks. However, little is known about the genetic diversity of hard ticks in China, especially at the subspecies level.

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Maternally inherited endosymbionts inhabit a variety of arthropods. Some of them can protect the arthropod host against a wide range of pathogens. However, very little is known about the association between endosymbionts and pathogen susceptibility in ticks.

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Background: Endosymbiotic bacteria inhabit a variety of arthropods including ticks and may have multiple effects on the host's survival, reproduction or pathogen acquisition and transmission. Rhipicephalus haemaphysaloides is one of the most widely distributed tick species in China. The symbiotic bacteria composition and their impacts to R.

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Background: Human babesiosis is considered an emerging threat in China. Dozens of human infections with Babesia microti have been reported recently, especially in southern China. However, the transmission vectors of this parasite in these areas are not well understood.

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Objective: To study the prevalence of tick bites and relative factors of outpatients with fever from health care facilities in Tengchong County.

Methods: From July to August, 2014, the outpatients with fever in five health care facilities namely Tengchong Center for Disease Control and Prevention, Hehua Health Center, Jietou Health Center, Qushi Health Center and Xinhua Health Center were investigated by questionnaires. The factors related to tick bites were explored with the univariate analysis and multiple regression models.

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The impacts of three kinds of human disturbances, i.e., non-grazing, reseeding and free-grazing, on plant community characters, i.

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  • The study aimed to evaluate how effective and safe Traditional Chinese Medicine (TCM) is for treating non-acute bronchial asthma that is complicated by gastroesophageal reflux.
  • Researchers analyzed data from six randomized controlled trials (RCTs) that included 304 patients, comparing TCM treatments with standard Western medical treatments.
  • Results indicated that TCM treatments had some benefits, with higher clinical efficacy and better improvements in asthma and reflux symptoms, but all trials had low methodological quality.
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Objective: To assess the prevalence and severity of restless legs syndrome (RLS) in a town in China and to explore potential factors correlated with the severity of the disease.

Methods: Face-to-face home interviews were conducted among a random sample of 2101 residents in one town in China, all aged 16 years and above. An individual questionnaire was administered to all participants to obtain a diagnosis of RLS and other information.

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Following the development of clinical trials, the methodology of clinical trials has developed a great deal, including randomization method and blinding method, etc. The method of randomization includes simple randomization, stratification randomization, etc. Dynamic randomization is also considered as a method of randomization.

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Blastocystis is a prevalent enteric protozoan that infects a variety of vertebrates. Infection with Blastocystis in humans has been associated with abdominal pain, diarrhea, constipation, fatigue, skin rash, and other symptoms. Researchers using different methods and examining different patient groups have reported asymptomatic infection, acute symptomatic infection, and chronic symptomatic infection.

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Intestinal multiparasitism, the accuracy of different diagnostic techniques, and the influence of sampling effort were studied among 215 individuals in a Bulang village, Yunnan province, People's Republic of China. Behavioral, demographic, and socioeconomic data were obtained by questionnaire. Multiple stool specimens were examined by the Kato-Katz, Koga agar plate, Baermann, and ether-concentration methods.

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Background: Strongyloides stercoralis is a neglected soil-transmitted helminth species, and there is a lack of parasitologic and epidemiologic data pertaining to this parasite in China and elsewhere. We studied the local occurrence of S. stercoralis in a village in Yunnan province, China, and comparatively assessed the performance of different diagnostic methods.

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