Publications by authors named "Lan-Anh Le"

Echinococcus ortleppi is the genotype G5 of Echinococcus granulosus sensu lato and is a zoonotic canine tapeworm of which larvae causes cystic diseases in domestic animals and also humans. While this species is highly endemic and widely spread in domestic animals, human infection is extremely rare and only sporadic, and thus, entire picture of human cystic echinococcosis due to infection with E. ortleppi is unclear.

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  • - The study focused on newly diagnosed acute myeloid leukemia (AML) patients to evaluate the impact of the immune marker CD81 on remission rates and drug response.
  • - Out of 50 patients, 80% were CD81 positive, revealing significantly higher mortality rates after chemotherapy and a poorer drug response compared to CD81-negative patients.
  • - The findings indicate that CD81 overexpression is linked to worse outcomes in AML, suggesting it could be an important factor in assessing prognosis and treatment effectiveness.
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Hairy cell leukemia (HCL) is a rare disease of mature B-cell neoplasms. Its name comes from the hair-like strands surrounding the cytoplasm of the cells, which are observed on peripheral blood or bone marrow smears. Leukemic cells mainly involve the spleen, peripheral blood, and bone marrow.

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CD38 is a glycoprotein that is highly and uniformly expressed in plasma cells in multiple myeloma. A panel of CD38 and CD138/CD19/CD45/CD56/CD117 markers is considered the immunophenotypic diagnosis of plasma cell myeloma. Expression of the CD38 marker may fade or weaken compared with the CD138 marker in plasma cells after chemotherapy treatment.

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T-cell large granular lymphocytic leukemia (T-LGL leukemia) is a rare, chronic lymphoproliferative disorder in the peripheral blood. This is characterized by peripheral blood and bone marrow (BM) lymphocytic infiltration with clonal large granular lymphocytes (LGLs). The neoplastic cells of this disease display a mature T-cell immunophenotype, with the majority of cases showing a CD4-/CD8+ T-cell, T-cell receptor (TCR) subset immunophenotype versus other permutations of those markers.

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  • Different rice farming systems have varying impacts on soil microbial communities.
  • The study focused on soils from both intensive rice cultivation and rice-shrimp farming systems in Soc Trang, Vietnam.
  • 16S rRNA gene sequencing revealed several dominant microbial phyla in these soil samples.
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  • Ancylostoma ceylanicum is a hookworm species that can mature in the human intestine and is known to infect humans in neighboring countries, but has not been reported in Vietnam until now.
  • A study conducted in Long An Province collected 526 fecal samples, revealing an overall human hookworm infection rate of 16.2%.
  • The presence of larvae confirmed the existence of two hookworm species, with single infections of Necator americanus and A. ceylanicum, as well as mixed infections occurring in the samples.
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  • The study analyzed the genetic factors associated with dilated cardiomyopathy (DCM) in 230 Vietnamese patients, finding a 23.5% diagnostic yield among familial and sporadic cases.
  • It identified TTN truncating variants as the most common genetic alteration, especially in younger patients, and established that genotype-positive individuals often experienced more severe cardiac issues compared to those with negative results.
  • The research highlights the importance of understanding the genetic landscape of DCM in Vietnam and suggests that addressing environmental factors may improve patient outcomes.
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Vietnam is one of the top shrimp producing and exporting countries in the world [1]. However, viral and bacterial epidemic diseases cause severe damages to shrimp farming, resulting in millions of US dollars losses annually [2]. Furthermore, inappropriate use of antibiotics in shrimp rearing lead to increased emergence of drug resistant pathogens [3].

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The scarcity of enzymes having an optimal activity in lignocellulose deconstruction is an obstacle for industrial-scale conversion of cellulosic biomass into biofuels. With the aim of mining novel lignocellulolytic enzymes, a ~9 Gb metagenome of bacteria in Vietnamese native goats' rumen was sequenced by Illumina platform. From the data, 821 ORFs encoding carbohydrate esterases (CEs) and polysaccharide lyases (PLs) serving for lignocellulose pre-treatment, 816 ORFs encoding 11 glycoside hydrolase families (GHs) of cellulases, and 2252 ORFs encoding 22 GHs of hemicellulases, were mined.

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Introduction: The strategies patients use to manage their asthma (coping) have been found to be associated with clinical and patient-reported outcomes.

Objectives: The aim of this large cross-sectional survey is to assess the use of coping methods employed by patients with asthma and to explore the ability of general practitioners (GPs) to correctly identify these strategies.

Methods: A modified Coping Orientations to Problem Experienced Questionnaire was completed by patients with asthma and their physicians.

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A coupled high performance liquid chromatography-hydride generation-atomic absorption spectroscopy system was used to determine the speciation of arsenic in samples from the Nha Trang Harbor, Vietnam. Concentrations of arsenic in seawater, pore water, suspended solid, and sediment were 4.12-9.

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The Red River (China/Vietnam, A=155,000 km(2)) is a typical humid tropics river originating from the mountainous area of Yunnan Province in China. Based on information on daily discharge (Q) and suspended particulate matter (SPM) concentration between 1960-2008 for the SonTay gauging station (outlet of the River and entry to the Delta) provided by the National Institute IMHE-MONRE, the mean annual SPM flux was estimated at 90 Mt/yr, corresponding to a sediment yield of 600 t/km(2)/yr. The temporal variability of annual SPM fluxes (ranging from 24 to 200 Mt/yr) is strongly related to the interannual hydrological conditions.

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