A clinical pilot trial of an artificial intelligence-driven smart phone application of bowel preparation for colonoscopy: a randomized clinical trial.

Background: High-quality bowel preparation is paramount for a successful colonoscopy. This study aimed to explore the effect of artificial intelligence-driven smartphone software on the quality of bowel preparation.

Methods: Firstly, we utilized 3305 valid liquid dung images collected mobile phones as training data.

Evaluation of Pregnancy Risks in Women with Subchorionic Hematoma Using Machine Learning Models.

BACKGROUND Subchorionic hematoma (SCH) can lead to blood accumulation and potentially affect pregnancy outcomes. Despite being a relatively common finding in early pregnancy, the effects of SCH on pregnancy outcomes such as miscarriage, stillbirth, and preterm birth remain debated. This study aims to address these gaps by systematically evaluating the influence of SCH-related clinical factors on pregnancy outcomes using robust analytical techniques.

Diagnostic Efficacy of Ventilation-Perfusion Single Photo Emission Computed Tomography/Computed Tomography for Pulmonary Hypertension due to Fibrinous Mediastinitis.

Rationale And Objectives: Comprehensive data on the use of ventilation-perfusion single-photo emission computed tomography/computed tomography (V/Q SPECT/CT), an established diagnostic tool for chronic thromboembolic pulmonary hypertension, in identifying pulmonary hypertension secondary to fibrinous mediastinitis (PH-FM) is scarce. This study aimed to assess its diagnostic efficacy for PH-FM.

Materials And Methods: Patients with PH due to pulmonary artery stenosis were assessed using V/Q SPECT/CT, computed tomography pulmonary angiography (CTPA), and digital subtraction pulmonary angiography (PAG).

Comparing the protection of heterologous booster of inhaled Ad5-nCoV vaccine and hybrid immunity against Omicron BA.5 infection: a cohort study of hospital staff in China.

Background: After the exit "zero-COVID" strategy in mainland China by the end of 2022, a large-scale COVID-19 outbreak seeded by Omicron variants occurred. An inhaled adenovirus type-5 vector-based (i.e.

Unlocking academic achievement of nursing master's students: ethical leadership, teacher-student relationship and growth mindset - a cross-sectional survey study.

Background: Academic achievement is a critical indicator of teaching quality. There has been limited exploration into the mechanisms underlying academic achievements among nursing master's students. This study investigated the relationship between ethical leadership and academic achievements, focusing on how the teacher-student relationship and growth mindset mediate this relationship.

Synthesis of dolutegravir derivatives modified by 1,2,3-triazole structure and their anti-inflammatory activity in LPS-induced BV2 cells.

Given the promising anti-inflammatory activity of the HIV integrase inhibitor dolutegravir and the widespread use of the 1,2,3-triazole structure in anti-inflammatory drug development, this study aimed to enhance dolutegravir's efficacy by introducing a 1,2,3-triazole group. As a result, four series of dolutegravir derivatives were synthesized. Screening these derivatives for anti-inflammatory activity in microglial cells revealed that compound 6k demonstrated the most potent anti-inflammatory effect without significant cytotoxicity.

Multidisciplinary approach improves eradication rate and safety in refractory Helicobacter pylori infection: Multidisciplinary approach for H. pylori.

Introduction: Helicobacter pylori (HP) infection is prevalent worldwide and contributes to various gastrointestinal diseases. Eradication therapy is crucial in managing HP infection, but antibiotic resistance has led to refractory cases, complicating treatment outcomes and increasing the risk of adverse events.

Objectives: This study aimed to evaluate the effectiveness of a multidisciplinary approach, termed HP Multidisciplinary Team (MDT) Clinic, in improving eradication rates and safety in patients with refractory HP infection.

[Study on the regularity of acupoint selection and compatibility of acupuncture and moxibustion in the treatment of Parkinson's disease based on complex network analysis].

Objectives: To analyze the regularity of acupoint selection and compatibility of acupuncture and moxibustion for Parkinson's disease (PD) using complex network analysis technology, so as to provide the basis and treatment strategies for clinical acupuncture and moxibustion treatment of PD.

Methods: Relevant literature published in databases of China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, and Web of Science from the inception to December of 2023 was retrieved. The literature was screened based on inclusion and exclusion criteria to establish a prescription database for acupuncture treatment of PD.

Internal hernia through the mesenteric defect in twin pregnancy: a case report and literature review.

Background: Internal hernias through mesenteric defects are rare, particularly in the context of twin pregnancies, and can lead to severe complications such as bowel obstruction and strangulation. Early diagnosis is critical, yet challenging, due to the overlapping symptoms with other abdominal conditions and the limited use of advanced imaging during pregnancy.

Case Description: We present a 33-year-old woman with a twin pregnancy at 33 + 2 weeks of gestation who experienced acute bowel obstruction due to an internal hernia through a congenital mesenteric defect.

Combining fire needle plus cupping with famciclovir and gabapentin in the treatment of acute herpes zoster: a revised intervention approach.

This study aimed to investigate the efficacy and safety of fire needle plus cupping (FC) combined with oral famciclovir and gabapentin for the treatment of acute-phase herpes zoster (AHZ). This study was conducted as a superiority, randomized controlled trial in which 84 patients with AHZ who met the diagnostic criteria were selected and randomly assigned to three groups on a 1:1 basis. Group A: received oral famciclovir with gabapentin treatment (FG); Group B: received fire needle plus cupping (FC) with FG.

MiR-302 targets PAK5 and prevents the transition from chronic hepatitis B to liver cirrhosis.

Objective: To determine and compare the levels of p21-activated kinase 5 messenger ribonucleic acid and microribonucleic acid 302 in the serum of patients with chronic hepatitis B, liver cirrhosis and healthy individuals, and to analyse the roles and correlation of p21-activated kinase 5 messenger ribonucleic acid and micro-ribonucleic acid 302 in the progression of chronic hepatitis.

Methods: The observational, clinical, case-control study was conducted at the Department of Laboratory Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China, from February 2021 to January 2022. Peripheral blood serum samples were collected from healthy individuals undergoing physical examinations, as well as from patients with chronic hepatitis B and hepatitis B-related liver cirrhosis.

Adverse childhood experiences and subsequent experiences of intimate partner violence in adulthood: a gender perspective.

Aims: Investigate the prevalence of adverse childhood experience (ACE) and intimate partner violence (IPV) using a large representative Chinese sample, explore the association mechanism between ACE and adult exposure to IPV and to examine gender differences.

Methods: A total of 21,154 participants were included in this study. The ACE scale was used to assess participants' exposure to ACE before the age of 18.

CAR T cells secreting NGF-neutralizing scFv enhance efficacy in clear cell renal cell carcinoma by relieving immunosuppression through immunosympathectomy.

Background: Chimeric antigen receptor (CAR) T cells have demonstrated remarkable breakthroughs in treating hematologic malignancies, yet their efficacy in solid tumors is limited by the immunosuppressive microenvironment. Sympathetic nerves significantly contribute to this immunosuppressive milieu in solid tumors. However, the impact of tumor sympathetic denervation on enhancing CAR T-cell antitumor efficacy remains unclear.

Long Non-Coding RNA LINC01116 Promotes the Proliferation of Lung Adenocarcinoma by Targeting miR-9-5p/CCNE1 Axis.

Long non-coding RNA (lncRNA) LINC01116 is crucial in promoting cell proliferation, invasion and migration in solid tumours, including lung adenocarcinoma (LUAD). LINC01116 acts as a competing endogenous RNAs (ceRNA) that binds competitively to microRNAs and plays a critical role in tumour migration and invasion. However, other mechanisms of action besides the ceRNA theory have been rarely reported and remain to be elucidated further.

[Analysis and Perspectives of MRI-Guided Proton Therapy Integrated Technology].

This article explores the MRI-guided proton therapy (MRiPT) integrated technology, which is magnetic resonance imaging-guided radiation therapy. By precisely controlling dose distribution, MRiPT has the potential to enhance the efficacy of radiotherapy. This article reviews the development of MRiPT, analyzes its potential for clinical application, and discusses technical challenges and potential solutions.

Mechanistic insights for efficient removal of intracellular and extracellular antibiotic resistance genes by iron-based nanocopper: Intracellular oxidative stress and internalization of nanocopper.

The widespread use of antibiotics has led to a severe pollution issue with antibiotic resistance genes (ARGs), which poses a significant threat to both ecological environments and human health. In this study, we developed an iron-based nanocopper bimetallic material (Fe-nCu) for the efficient removal of ARGs. Our results indicate that nCu can attach to the surface of iron, forming aggregated copper nanoclusters resembling wheat ears.

Stressor-Actuated Proximity Labeling for Reporting Cellular Interaction.

Cell-cell interactions determine the activation state and function of cells. When host cells are exposed to stressors such as microorganisms, immune defense machinery is activated to release HO, providing direct evidence of the relevant cellular physiological processes. Inspired by the fact that peroxidase can catalyze proximity labeling in the presence of exogenous HO, a stressor-actuated proximity labeling (SAPL) strategy is developed to report the process information on cell-cell interactions by recording stress levels.

Primary dedifferentiated liposarcoma of the gallbladder: a case report and literature review.

Background: Liposarcoma (LPS) is a kind of malignancy of soft tissue usually found in the retroperitoneal, limb, or neck region, and some may be detected with delayed symptoms (pain or palpable mass), and less frequently occurs in organs of the digestive system. In contrast, Dedifferentiated liposarcoma (DDLPS) is a common histological subtype of LPS. The present study reported a case of dedifferentiated liposarcoma originating in the gallbladder.

YY1 downregulation underlies therapeutic response to molecular targeted agents.

During targeted treatment, oncogene-addicted tumor cells often evolve from an initial drug-sensitive state through a drug-tolerant persister bottleneck toward the ultimate emergence of drug-resistant clones. The molecular basis underlying this therapy-induced evolutionary trajectory has not yet been completely elucidated. Here, we employed a multifaceted approach and implicated the convergent role of transcription factor Yin Yang 1 (YY1) in the course of diverse targeted kinase inhibitors.

Bioinformatics Analysis and Immunogenicity Assessment of the Novel Multi-Stage DNA Vaccine W541 Against Mycobacterium Tuberculosis.

Background: Vaccination is one of the effective measures to prevent latent tuberculosis infection (LTBI) from developing into active tuberculosis (TB). Applying bioinformatics methods to pre-evaluate the biological characteristics and immunogenicity of vaccines can improve the efficiency of vaccine development.

Objectives: To evaluate the immunogenicity of TB vaccine W541 and to explore the application of bioinformatics technology in TB vaccine research.