Publications by authors named "Lan Vuong"
Background: The ovarian response to gonadotropin stimulation varies widely among women, and could impact the probability of live birth as well as treatment risks. Many studies have evaluated the impact of different gonadotropin starting doses, mainly based on predictive variables like ovarian reserve tests (ORT) including anti-Müllerian hormone (AMH), antral follicle count (AFC), and basal follicle-stimulating hormone (bFSH). A Cochrane systematic review revealed that individualizing the gonadotropin starting dose does not affect efficacy in terms of ongoing pregnancy/live birth rates, but may reduce treatment risks such as the development of ovarian hyperstimulation syndrome (OHSS).
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- - The study aimed to identify serum anti-Müllerian hormone (AMH) and antral follicle count (AFC) thresholds that signal a higher risk of hyper-response to ovarian stimulation in women undergoing their first IVF cycle, following the HERA definition.
- - A total of 4220 women were analyzed, revealing thresholds of AMH≥4.38ng/mL and AFC≥16 for the overall cohort, with varying thresholds based on age groups.
- - The findings highlighted that factors like AMH, AFC, and age significantly predict the likelihood of hyper-response during ovarian stimulation, with older women requiring more hormonal treatment.
Study Question: Among couples with infertility and normal total sperm count and motility, can sperm morphology be used as a biomarker to identify couples who benefit more from ICSI over conventional IVF (c-IVF) on fertility outcomes?
Summary Answer: Based on this secondary analysis of a large randomized clinical trial (RCT), sperm morphology has limited value as a biomarker to identify couples who benefit more from ICSI over c-IVF on live birth, ongoing pregnancy, clinical pregnancy or total fertilization failure.
What Is Known Already: Our recent RCT showed that ICSI did not result in higher live birth rates in couples with normal total sperm count and motility. It is unclear whether sperm morphology can be used as a biomarker to identify couples who benefit more from ICSI over c-IVF in this population.
Background: Caesarean scar ectopic pregnancy (CSEP) is associated with significant maternal and foetal morbidity. However, the optimal treatment remains unknown.
Objectives: The aim of this study was to review outcomes reported in studies on CSEP treatment and outcome reporting quality.
Background: For asymptomatic individuals with a singleton pregnancy and a short cervix, vaginal progesterone significantly decreases the risk of PTB and improves perinatal outcomes. Cervical pessary is another option that has been evaluated with inconclusive results. There is, however, a lack of head-to-head comparisons between pessary and vaginal progesterone in this high risk population.
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- This study explores how the daily dose of follicle-stimulating hormone (FSH) impacts the chances of suboptimal ovarian response during IVF, specifically using POSEIDON's criteria.
- It examines a group of 4005 women with normal hormone levels undergoing their first IVF/ICSI cycle, assessing whether varying FSH doses (≤300 IU vs >300 IU) influence the retrieval of 4-9 oocytes.
- Results show that increasing the FSH dose did not decrease the risk of suboptimal response, while factors like female age, and hormone levels were found to be significant predictors instead.
Article Synopsis
- A panel of international experts evaluated and discussed the POSEIDON criteria, aiming to improve management strategies for women with low prognosis in assisted reproductive technology (ART).
- Through a Delphi consensus process involving multiple rounds of voting, 53 experts reviewed 17 statements and reached consensus on their relevance for patient care and outcomes in ART.
- Key recommendations include using specific treatments and tools to enhance success rates, while emphasizing the need for more large-scale studies to validate existing findings.
To analyze whether combinations of polymorphisms within FSHR gene influence ovarian response (OR) to stimulation. A multicenter prospective cohort study was conducted from 11/2016-06/2019 in Europe and Asia including predicted normo-responders under 38y. Patients underwent ovarian stimulation using fixed-dose 150 IU rFSH in a GnRH antagonist protocol.
View Article and Find Full Text PDFObjective: To compare oocyte maturation rates and pregnancy outcomes in women with polycystic ovary syndrome (PCOS) undergoing biphasic in vitro maturation (capacitation in vitro maturation [CAPA-IVM]) with vs. without follicle-stimulating hormone (FSH) priming.
Design: Randomized, controlled, assessor-blinded trial.
Purpose: Although some immune protection from close contact with individuals who have coronavirus disease 2019 (COVID-19) has been documented, there is limited data on the seroprevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals who were in lockdown with confirmed COVID-19 cases. This study investigated immunogenicity against SARS-CoV-2 in household members and people who lived near home-quarantined patients with COVID-19.
Materials And Methods: This cross-sectional study was conducted during the community-based care that took place during lockdowns in District 10, Ho Chi Minh City, Vietnam from July to September 2021.
Live birth after vitrification of oocytes from capacitation in vitro maturation.
J Assist Reprod Genet
August 2024
Female fertility preservation is a rapidly growing field in medicine. Oocyte cryopreservation and assisted reproductive technique with vitrified-warmed oocytes have been successful with in vivo matured oocytes after conventional ovarian stimulation protocols. The use of in vitro matured oocytes after vitrification and warming has been limited.
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- A study was conducted to compare different methods of preparing the endometrium (lining of the uterus) for frozen embryo transfers (FET) in women undergoing IVF.
- The women, aged 18-45, were randomly assigned to one of three groups: natural cycle (no medication), modified natural cycle (using hCG to trigger ovulation), or artificial cycle (using estrogen and progesterone).
- Results showed that the live birth rates after one FET were 37% for the natural cycle, 33% for the modified natural cycle, and 34% for the artificial cycle, with more cancellations in the natural and modified groups compared to the artificial cycle.
Purpose: This study investigated the differences in the maturation rate of single versus grouped cumulus-oocyte complexes (COCs) culture methods for capacitation in vitro maturation (CAPA-IVM) in women with polycystic ovary syndrome (PCOS).
Methods: This study was performed at My Duc Phu Nhuan Hospital, Vietnam from October 1, 2020 to October 24, 2021. Women aged 18-37 years with a diagnosis of PCOS were recruited.
Study Question: In non-male factor infertile couples, are there any differences in the developmental outcomes between children born through ICSI and conventional IVF (cIVF)?
Summary Answer: In this preliminary study, ICSI and cIVF seem to have a comparable effect on developmental outcomes after 12 months in children born to non-male factor infertile couples.
What Is Known Already: ICSI, an invasive technique, has raised concerns about potential developmental abnormalities in children. Limited data are available regarding the developmental outcomes of ICSI-conceived infants born to non-male factor infertile couples.
Introduction: Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is rare condition that has a negative impact on quality of life because affected women lack a uterus and vagina, and are therefore unable to engage in sexual intercourse and experience natural pregnancy. This study evaluated perceptions of surrogacy in Vietnamese women with MRKH who have started families.
Method: Women with MRKH who had undergone successful vaginal reconstruction, were married, and had started families participated in a semi-structured, in-depth, one-on-one online video interview with an experienced female psychologist.
Article Synopsis
- - The study investigates clinical factors linked to unexpected poor or suboptimal responses in IVF ovarian stimulation, identifying specific thresholds for AMH and AFC that could predict these outcomes according to POSEIDON's criteria.
- - Conducted from 2015 to 2017, this tri-centre retrospective cohort study analyzed data from 7,625 first-time IVF and ICSI cycles, revealing that 9.3% were poor responders and 90.7% were suboptimal responders.
- - The findings suggest that higher than expected AMH and AFC threshold values can predict poor or suboptimal responses, emphasizing the importance of these markers for customizing IVF treatment plans.
Article Synopsis
- - The study aimed to investigate the risks associated with differing ovarian reserve markers (AMH and AFC) in women undergoing IVF, particularly when one indicates normal reserve and the other suggests poor reserve according to Poseidon's criteria.
- - In a cohort of 8,797 women, 13.3% had discordant AMH and AFC values; 72.9% of these women still retrieved 4 or more oocytes, indicating that discordant markers don't always predict poor ovarian response.
- - The findings suggest that an AFC of 6 is a good predictor of successful oocyte retrieval even when AMH is low, while low AFC paired with higher AMH indicates a lower likelihood of poor response to stimulation.
Article Synopsis
- In vitro maturation (IVM) is gaining recognition in assisted reproductive techniques due to its proven safety and effectiveness.
- Recent improvements in IVM methods and supportive data are highlighting its advantages over traditional in vitro fertilization, especially for specific patient groups.
- As understanding and accessibility of IVM increase, its potential to benefit a wider range of patients continues to grow, making it a promising option in fertility treatment.
Embryological and clinical outcomes in couples with severe male factor infertility versus normozoospermia.
Eur J Obstet Gynecol Reprod Biol
March 2024
Objective: This study evaluated embryological and clinical outcomes in couples with severe male factor infertility versus those with normozoospermia undergoing ICSI and in vitro fertilisation.
Methods: This multicentre, retrospective cohort study included all couples who had undergone autologous ICSI cycles at My Duc Hospital and My Duc Phu Nhuan Hospital in Vietnam between January 2018 and January 2021 (female age < 35 years and males with severe male factor or normozoospermia based on the World Health Organization 2010 criteria). The primary outcome was the cumulative live birth rate after the first ICSI cycle.
Objective: The purpose of this study was to identify factors associated with twin pregnancy following day 3 double embryo transfer (DET).
Methods: This retrospective cohort study incorporated data from 16,972 day 3 DET cycles. The participants were women aged between 18 and 45 years who underwent in vitro fertilization with intracytoplasmic sperm injection (IVF/ICSI) at My Duc Assisted Reproduction Technique Unit (IVFMD), My Duc Hospital, located in Ho Chi Minh City, Vietnam.
Article Synopsis
- The study investigates the global DNA methylation differences in neonates conceived through two methods: capacitation-IVM (CAPA-IVM) and conventional IVF.
- Biological samples from both groups were collected at delivery, primarily focusing on placental tissue, cord blood, and buccal smears, analyzed for methylation using advanced techniques.
- Results indicate that while there were no significant differences in neonatal buccal smears, CAPA-IVM was linked to specific changes in DNA methylation patterns in placental tissue and showed variability in cord blood compared to conventional IVF, but without changes in gene expression.
Article Synopsis
- Recent advancements in in vitro maturation (IVM) of oocytes, particularly through biphasic IVM, show promise for improving assisted reproductive technologies (ART) by allowing collection of immature oocytes from minimally stimulated patients and incorporating a preparatory culture phase.
- The review aims to highlight significant scientific discoveries in ovarian biology and detail the new pre-IVM methodologies, alongside assessing outcomes from both animal studies and clinical trials in humans.
- By reducing the reliance on gonadotrophins and utilizing developing oocytes from small antral follicles, biphasic IVM could potentially enhance the safety and efficiency of fertility treatments.
To compare the rate of positive thyroid peroxidase antibodies (TPO Ab) between women with different polycystic ovary syndrome (PCOS) phenotypes and women without PCOS. This is a retrospective cohort study. Women with PCOS at My Duc Hospital between June 1, 2020, and March 27, 2021, were matched with non-PCOS women by age.
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