Gelated Vorinostat with inner-lysosome triggered release for tumor-targeting chemotherapy.

Histonedeacetylase inhibitor (HDACi) has great potential in targeted antitumor therapy by inhibiting tumor migration, invasion, and metastasis. As one of the typical HDACis, vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) was approved as a therapeutic agent for cancer therapy, however, challenges remain due to their poor solubility, short half-life and low efficiency in cellular penetration. Considering the disadvantages of usual drug carriers, folate and vorinostat bound BSA nanogel (FVBN)was fabricated to implement higher solubility, stability, cellular uptake, and lipase-responsive release.

Functional-Group Modification of Kraft Lignin for Enhanced Supercapacitors.

Recent efforts to improve the capacitances of Kraft lignin (KL) in supercapacitors have mainly focused on screening KL substrates, which could either compensate the poor conductivity of KL or directly contribute to the capacitance. However, increasing the pseudocapacitance contributed by KL itself, through hydroquinone/quinone redox cycles, remains a challenge, owing to the roughly fixed content of hydroquinone species in natural KL. In this study, the capacitance of KL is greatly improved by using a functional-group modification strategy in which methoxy groups in KL are selectively converted into phenolic hydroxy groups, which facilitate the formation of additional hydroquinone moieties and thus lead to higher pseudocapacitances.

Surface Anchoring Approach for Growth of CeO Nanocrystals on Prussian Blue Capsules Enable Superior Lithium Storage.

Prussian blue (PB) and its analogues (PBAs) have been acknowledged as promising materials for the catalysis, energy storage, and bioapplications because of different constructions and tunable composition. The approach for surface modification with metal oxides for boosting the performance, however, is rarely reported. Herein, a facile surface anchoring strategy has been proposed to realize CeO nanocrystals uniformly depositing on the surface of PB.

Folate-mediated and pH-responsive chidamide-bound micelles encapsulating photosensitizers for tumor-targeting photodynamic therapy.

 Nonspecific tumor targeting, potential relapse and metastasis of tumor after treatment are the main barriers in clinical photodynamic therapy (PDT) for cancer, hence, inhibiting relapse and metastasis of tumor is significant issues in clinic. In this work, chidamide as a histone deacetylases inhibitor (HADCi) was bound onto a pH-responsive block polymer folate polyethylene glycol--poly(aspartic acid) (PEG--PAsp) grafted folate (FA-PEG--PAsp) to obtain the block polymer folate polyethylene glycol--poly(asparaginyl-chidamide) (FA-PEG--PAsp-chidamide, FPPC) as multimodal tumor-targeting drug-delivery carrier to inhibiting tumor cell proliferation and tumor metastasis in mice.  Model photosensitizer pyropheophorbide- (Pha) was encapsulated by FPPC in PBS to form the polymer micelles Pha@FPPC [folate polyethylene glycol--poly(asparaginyl-chidamide) micelles encapsulating Pha].

Immunotoxicity assessment of ordered mesoporous carbon nanoparticles modified with PVP/PEG.

With large surface area and three-dimensional pore structure, mesoporous carbon nanoparticles (MCN) have attracted enormous interests as potential drug carriers. However, MCN immunotoxicity has not been clarified clearly up to now. Herein we reported the effect of MCN with and without PVP or DSPE mPEG2000 (PEG) modification on immune cells including dendritic cells (DCs), T lymphocytes and RAW264.

Magnetic and pH dual-responsive mesoporous silica nanocomposites for effective and low-toxic photodynamic therapy.

Nonspecific targeting, large doses and phototoxicity severely hamper the clinical effect of photodynamic therapy (PDT). In this work, superparamagnetic FeO mesoporous silica nanoparticles grafted by pH-responsive block polymer polyethylene glycol--poly(aspartic acid) (PEG--PAsp) were fabricated to load the model photosensitizer rose bengal (RB) in the aim of enhancing the efficiency of PDT. Compared to free RB, the nanocomposites (polyethylene glycol--polyaspartate-modified rose bengal-loaded magnetic mesoporous silica [RB-MMSNs]) could greatly enhance the cellular uptake due to their effective endocytosis by mouse melanoma B16 cell and exhibited higher induced apoptosis although with little dark toxicity.

Hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy.

In this study, a highly effective transmembrane delivery vehicle based on PEGylated oxidized mesoporous carbon nanosphere (oMCN@PEG) was successfully fabricated in a facile strategy. oMCN@PEG exhibited a narrow size distribution of 90 nm, excellent hydrophilicity, good biocompatibility, and a very high loading efficiency for doxorubicin (DOX). The drug system (oMCN@DOX@PEG) exhibited excellent stability under neutral pH conditions, but with dramatic releases of DOX at reduced pH conditions.

High-resolution electron microscopy study of mesoporous dichalcogenides and their hydrogen storage properties.

In this work, we report a detailed investigation on the surface topology of ordered mesoporous WS(2) nanoarrays nanocast from the silica SBA-15 template. Using a high-resolution scanning electron microscopy (HRSEM) technique, we acquire distinguishably clear images of the WS(2) surface. A large number of small nanorods are found to be evenly distributed among the nanowire arrays, supporting their ordered mesostructures.

[Spectroscopic study on the effect of crystallization of the hydroxyapatite on the secondary structure of bovine serum albumin].

The effect of crystallization of hydroxyapatite on the secondary structure of bovine serum albumin (BSA) was studied by circular dichroism spectrum, Fourier transform infrared spectroscopy, derivative, deconvolution and curve-fitting techniques in the present paper. The CD results show that pure bovine serum albumin is composed of 56.8% alpha-helices, 5.