Publications by authors named "Lan S Shuang"
Article Synopsis
- * The huR83C mouse model replicates the disease phenotype and has been used to test the effectiveness of BEAM-301, a treatment that utilizes lipid nanoparticles and adenine base editing to correct the harmful G6PC1-R83C variant.
- * BEAM-301 has shown the ability to correct about 60% of the variant in liver cells, restore blood sugar control, improve overall health, and increase survival rates in mice, indicating its potential as a therapeutic option for patients with this specific genetic mutation
Chronic hepatitis B virus (HBV) infection remains a global health problem due to the lack of treatments that prevent viral rebound from HBV covalently closed circular (ccc)DNA. In addition, HBV DNA integrates in the human genome, serving as a source of hepatitis B surface antigen (HBsAg) expression, which impairs anti-HBV immune responses. Cytosine base editors (CBEs) enable precise conversion of a cytosine into a thymine within DNA.
View Article and Find Full Text PDFTo improve resolution to small genomic regions and sensitivity to small-effect loci in the identification of genetic factors conferring the enlarged inflorescence and other traits of cauliflower while also expediting further genetic dissection, 104 near-isogenic introgression lines (NIILs) covering 78.56% of the cauliflower genome, were selected from an advanced backcross population using cauliflower [Brassica oleracea var. botrytis L.
View Article and Find Full Text PDFArticle Synopsis
- The study examines the genetic factors influencing flowering time in Brassica napus, using a recombinant inbred line (RIL) population across six different environments.
- Researchers discovered 27 quantitative trait loci (QTLs), with a significant QTL on chromosome C02 explaining a notable portion of the variation in flowering time across all environments.
- RNA-Seq analysis identified 105 differentially expressed genes (DEGs) related to flowering time, with 45 of these genes located in QTL regions, including important genes like PSEUDO RESPONSE REGULATOR 7 (PRR7) and FY.