Annexin A1: The dawn of ischemic stroke (Review).

Ischemic stroke is a prevalent clinical condition that poses a significant global challenge. Developing innovative strategies to address this issue is crucial. Annexin A1 (ANXA1), a key member of the annexin superfamily, performs various functions, such as inhibiting inflammatory factor release, promoting phagocytosis, and blocking leukocyte migration.

A multi-responsive 3D deformable soft actuator with tunable structural color enabled by a graphene/cholesteric liquid crystal elastomer composite.

Intelligent soft robots that integrate both structural color and controllable actuation ability have attracted substantial attention for constructing biomimetic systems, biomedical devices, and soft robotics. However, simultaneously endowing single-layer cholesteric liquid crystal elastomer (CLCE) soft actuators with reversible 3D deformability and vivid structural color changes is still challenging. Herein, a multi-responsive (force, heat and light) single-layer 3D deformable soft actuator with vivid structural color-changing ability is realized through the reduced graphene oxide (RGO) deposition-induced Janus structure of the CLCE using a precisely-controlled evaporation method.

Xiaoxuming decoction enhanced neuroprotection after cerebral ischemia/reperfusion via the JAK2/STAT3 signaling pathway based on UPLC/HRMS, network pharmacology and experimental validation.

Ethnopharmacological Relevance: Xiao-xu-ming decoction (XXMD), a prominent traditional Chinese medicinal formula historically revered for stroke treatment, demonstrates pronounced efficacy in ameliorating ischemic stroke injury.

Aim Of The Study: This study aims to investigate the effects and mechanisms of XXMD on neuroprotection subsequent to cerebral ischemia/reperfusion in vivo and in vitro.

Materials And Methods: Neurobehavioral test, TTC staining, HE staining and nissl staining were used to examine the neuroprotective effect of XXMD on cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO) in rats.

Role of viruses in periodontitis: An extensive review of herpesviruses, human immunodeficiency virus, coronavirus-19, papillomavirus and hepatitis viruses.

Periodontitis is the inflammation of the supporting structures around the dentition. Several microbial agents, mostly bacteria, have been identified as causative factors for periodontal disease. On the other hand, oral cavity is a rich reservoir for viruses since it contains a wide variety of cell types that can be targeted by viruses.

Xiao-xu-ming decoction improved synaptic damage after acute cerebral ischemia and reperfusion via JAK2/STAT3 pathway in rats.

Ethnopharmacological Relevance: Ischemic stroke is an important cause of death and disability worldwide. Xiao-xu-ming Decoction (XXMD) is a classic prescription for the treatment of stroke patients, which has been widely used in China and has significant therapeutic effect, but the therapeutic target and mechanism are still unclear.

Aim Of The Study: The current study aimed to investigate temporal alternation of synaptic damage and the protective effects of XXMD on synaptic damage following cerebral ischemia and reperfusion in vivo.

Global occurrence, food web transfer, and human health risks of polycyclic aromatic hydrocarbons in biota.

Polycyclic aromatic hydrocarbons (PAHs) are widespread organic pollutants that pose significant health risks due to their bioaccumulation in the biota. This study examines the global distribution of PAHs in biota, identifies key factors influencing using boosted regression tree (BRT) models, analyzes their transfer through trophic magnification factors (TMF), and evaluates health risks using the EPA risk assessment model. Research on PAHs has grown from 1978 to 2023, peaking in 2021, with 171 out of 241 studies (71.

Cytochrome P450-derived Epoxyeicosatrienoic Acid, the Regulation of Cardiovascular-related Diseases, and the Implication for Pulmonary Hypertension.

Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid (AA) into biologically active epoxyeicosatrienoic acids (EETs), forming a pivotal metabolic pathway (AA-CYP-EETs-soluble epoxide hydrolase-dihydroxyeicosatrienoic acids) implicated in the progression of various disorders. Inflammation is a key contributor to the onset and progression of numerous systemic diseases, and EETs play a significant role in mitigating inflammation. Extensive research highlights the cardiovascular protective effects of EETs, which include vasodilation, anti-hypertensive, and anti-atherosclerotic properties.

Degradation of molybdenum disulfide through cascade reactions with hydrogen peroxide in aqueous system.

Transformation is a crucial process determining the lifespan and risk of MoS nanomaterial during usage and after disposal. This study revealed the degradation of MoS in the presence of HO using experimental and computational methods. Experimental results showed that MoS nanosheets were degraded by 45.

Atherosclerotic renal artery stenosis, mediating biomarkers, and risk of cardiac among individuals with hypertension: A real-world study.

Background: Atherosclerotic renal artery stenosis (ARAS) is commonly associated with cardiovascular diseases(CVD). Patients with ARAS typically present with cardiac structural and functional abnormalities, and the differences in cardiac structure and function compared to hypertensive patients without ARAS remain to be explored.

Methods: A total of 499 hypertensive patients were included, of whom 134 had ARAS and 365 had no renal artery stenosis (RAS).

CSTAN: A Deepfake Detection Network with CST Attention for Superior Generalization.

With the advancement of deepfake forgery technology, highly realistic fake faces have posed serious security risks to sensor-based facial recognition systems. Recent deepfake detection models mainly use binary classification models based on deep learning. Despite achieving high detection accuracy on intra-datasets, these models lack generalization ability when applied to cross-datasets.

Deciphering epidemiology through culture-independent multiplex amplicon and metagenomic sequencing.

Unlabelled: Whooping cough (pertussis) has re-emerged despite high vaccine coverage in Australia and many other countries worldwide, partly attributable to genetic adaptation of the causative organism, to vaccines. Therefore, genomic surveillance has become essential to monitor circulating strains for these genetic changes. However, increasing uptake of PCR for the diagnosis of pertussis has affected the availability of cultured isolates for typing.

Associations between maternal microbiome, metabolome and incidence of low-birth weight in Guatemalan participants from the Women First Trial.

Background: Low birth weight (LBW; <2,500 g) affects approximately 15 to 20 percent of global births annually and is associated with suboptimal child development. Recent studies suggest a link between the maternal gut microbiome and poor obstetric and perinatal outcomes. The goal of this study was to examine relationships between maternal microbial taxa, fecal metabolites, and maternal anthropometry on incidence of LBW in resource-limited settings.

The Disaggregated Oswestry Disability Index: What is the Most Predictive Subsection for Patient Satisfaction After Lumbar Surgery?

Study Design: Retrospective review of cohort studies.

Objective: To analyze how different ODI subsections and their improvement affect patient satisfaction 2 years after elective lumbar surgery for degenerative lumbar spondylolisthesis (DLS).

Background: The Oswestry Disability Index (ODI) is crucial in evaluating outcomes of spinal disorders and provides valuable insights into a patient's preoperative status.

An Innovative One Health Approach: BIOQUALIM, a Transdisciplinary Research Action Protocol-From Cultivated Biodiversity to Human Health Prevention.

Background/objectives: The "One Health" approach underscores the connection between human, animal, and environmental health, promoting solutions to global challenges like climate change and biodiversity loss. The Planetary Health Diet (PHD) promotes a plant-based diet with organically grown plants to reduce the environmental impact of meat production and decrease the risk of non-communicable diseases (NCDs). The BIOQUALIM project will evaluate the PHD's effectiveness in preventing NCDs like periodontal diseases and cancers through four inter-related studies.

French Version of the User Mobile Application Rating Scale: Adaptation and Validation Study.

Background: Managing noncommunicable diseases effectively requires continuous coordination and monitoring, often facilitated by eHealth technologies like mobile health (mHealth) apps. The end-user version of the Mobile Application Rating Scale is a valuable tool for assessing the quality of mHealth apps from the user perspective. However, the absence of a French version restricts its use in French-speaking countries, where the evaluation and regulation of mHealth apps are still lacking, despite the increasing number of apps and their strong relevance in health care.

A multimodality score strategy for assessing the risk of immune checkpoint inhibitors related cardiotoxicity.

This study aimed to find the association between four common clinical biomarkers and subsequent ICICT, developing a risk scoring strategy to assess the ICICT risk. Three terminals for ICICT were : Terminal 1, cancer therapy-related cardiomyopathies; Terminal 2, myocarditis or heart failure; and Terminal 3, myocarditis, heart failure, myocardial infarction, cerebral infarction, atrial fibrillation, or death. The thresholds were : N-terminal-pro-B-type-natriuretic-peptide ≥ 125 pg/mL, cardiac troponin T ≥ 6 ng/L, high-sensitivity C-reactive protein ≥ 3 mg/L, and coronary artery calcium score > 10 U.

Reconfigurable Visible Light-Driven Liquid Crystalline Network Showing Off-Equilibrium Motions Enabled by Mesogen-Grafted Donor-Acceptor Stenhouse Adducts.

Liquid crystalline network (LCN)-based soft actuators have opened up great opportunities to fabricate emerging and intriguing smart materials, serving as potential building blocks for intelligent soft robotics. Endowing LCN actuators with complex responsive behaviors to enhance their intelligence is both challenging and highly demanded. Herein, Donor-Acceptor Stenhouse Adducts (DASAs) molecules with rod-like mesogen and the polymerizable group are judiciously designed and synthesized, which is strong-colored at linear form and de-coloration at cyclic form after visible light.

The Impact of Paraspinal Muscle Degeneration on Oswestry Disability Index Subsections Two Years After Spinal Surgery for Degenerative Lumbar Spondylolisthesis.

Study Design: Secondary analysis of prospective study.

Objective: To investigate the impact of fatty infiltration (FI) in the paraspinal muscles (PM) on postoperative Oswestry Disability Index (ODI) subsection-scores in patients undergoing elective lumbar surgery for degenerative lumbar spondylolisthesis (DLS).

Background: DLS can increase FI in the PM like the multifidus (MF), erector spinae (ES), and psoas (PS), leading to greater spinal disability and higher ODI-scores.

Association between MMP-9-C1562Tpolymorphism and susceptibility to preeclampsia: a systematic review and meta-analysis.

Objectives: This meta-analysis aims to explore the association between MMP-9-C1562T polymorphism and susceptibility to preeclampsia (PE).

Material And Methods: Four English databases were searched to collect relevant records up to April 2024. The pooled odds ratio (OR) was calculated using Stata 15.