Publications by authors named "Lan Phu Huong Nguyen"
Article Synopsis
- Hypervirulent Klebsiella pneumoniae (hvKp) is a major cause of severe infections in Vietnam, with a study identifying 14.3% of bloodstream infections caused by this pathogen among 700 samples, along with its presence in healthy adults but not in children.
- Genetic diversity was noted among hvKp isolates, with 17 different sequence types identified, and about 12.6% carried antimicrobial resistance genes, which can spread between strains through specific plasmids.
- The study highlights the connection between intestinal carriage and the spread of hvKp infections, emphasizing the need for better surveillance and the use of molecular assays for effective diagnosis and management.
Genomic characterization of spp. isolates from striped catfish with motile septicemia and human bloodstream infections in Vietnam.
Microb Genom
May 2024
Article Synopsis
- The study investigated 87 isolates of bacteria related to motile septicemia (MAS) in striped catfish and 25 human bloodstream infection isolates, focusing on species identification and genetic characteristics during MAS outbreaks between 2012-2022 in the Mekong Delta and 2010-2020 for humans.
- Genomic analysis revealed ST656 and ST251 as the dominant virulent strains in catfish, showing evidence of extensive transmission and significantly higher antimicrobial resistance (AMR) genes compared to other strains.
- The research contributes to understanding the genetic landscape and epidemiology of these bacteria, highlighting their public health impact and the potential for vaccine development through identified conserved proteins.
Extra-intestinal pathogenic (ExPEC) ST1193, a globally emergent fluoroquinolone-resistant clone, has become an important cause of bloodstream infections (BSIs) associated with significant morbidity and mortality. Previous studies have reported the emergence of fluoroquinolone-resistant ExPEC ST1193 in Vietnam; however, limited data exist regarding the genetic structure, antimicrobial resistance (AMR) determinants and transmission dynamics of this pandemic clone. Here, we performed genomic and phylogenetic analyses of 46 ST1193 isolates obtained from BSIs and healthy individuals in Ho Chi Minh City, Vietnam, to investigate the pathogen population structure, molecular mechanisms of AMR and potential transmission patterns.
View Article and Find Full Text PDFThe emergence of carbapenem resistance in represents a major global public health concern. Nosocomial outbreaks caused by multidrug-resistant are commonly reported to result in high morbidity and mortality due to limited treatment options. Between October 2019 and January 2020, two concurrent high-mortality nosocomial outbreaks occurred in a referral hospital in Ho Chi Minh City, Vietnam.
View Article and Find Full Text PDFCryptococcosis causes approximately 180 000 deaths each year in patients with human immunodeficiency virus (HIV). Patients with other forms of immunosuppression are also at risk, and disease is increasingly recognized in apparently immunocompetent individuals. Cryptococcus neoformans var.
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